Vesicles of Non-ionic Surfactants (Niosomes) and Drug Delivery Potential
DOI:
https://doi.org/10.37285/ijpsn.2008.1.1.1Abstract
Vesicles prepared from self-assembly of hydrated non-ionic surfactants molecules are called niosomes. These types of vesicles were first reported in the cosmetic industries. Niosomes exhibit more chemical stability than liposomes (a phospholipids vesicle) as non-ionic surfactants are more stable than phospholipids. Non-ionic surfactants used in formation of niosomes are polyglyceryl alkyl ether, glucosyl
dialkyl ether, crown ether, polyoxyethylenealkyl ether, ester-linked surfactants, and steroid-linked surfactants and a spans, and tweens series. Niosomes preparation is affected by processes variables, nature of surfactants, and presence of membrane additives and nature of drug to be encapsulated. This review article presents an overview of theoretical concept of factors affecting niosome formation, techniques of noisome preparation, characterization of niosome, applications, limitations and market status of such delivery system.
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Keywords:
Niosomes, Liposomes, Anticancer, Surfactant, Proniosomes, Cholesterol
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Published
2008-05-31
How to Cite
1.
Biswal S, Murthy P, Sahu J, Sahoo P, F A. Vesicles of Non-ionic Surfactants (Niosomes) and Drug Delivery Potential. Scopus Indexed [Internet]. 2008 May 31 [cited 2024 Jul. 6];1(1):1-8. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/266
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Review Articles
References
Aggarwal D, and Kaur IP. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal opthalmic drug delivery system. Int.J. Pharm. 290: 155 (2005).
Aggarwal D. et al. Development of topical niosomal preparation of acetazolamide: preparation and evaluation. J. Pharm. Pharmacol. 56(12): 1509 (2004).
Almira I. Blazek-welsh I A and Rhodes G D. Maltodextrin –Based proniosomes.AAPS PharmSciTech. 3 : 36.(2001).
Alsarra AI, Bosela AA, Ahmed MS, and Mahrous M G.Proniosomes as a drug carrier for Arunothayanum P. et al. Investigation into the in vitro/in vivo behaviour of polyhedral niosomes. J. Pharm.Pharmcol. 50(supp): l169 (1998).
Arunothayanun P. et al. The effect of processing variables on the physical characteristics of nonionic surfactant vesicles (niosomes) formed from hexadecyl diglycerol ether. Int. J. Pharm. 201: 7(2000).
Arunothayanun P. et al. Extrusion of niosomes from capillaries: approaches to a pulsed delivery device.J.Cont.Release. 60: 391 (1999).
Azmin MN. et al., The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J Pharm. Pharmacol. 37: 237 (1985).
Baillie AJ. The preparation and properties of niosomes-nonionic surfactant vesicles. J.Pharm. Pharmacol. 37: 863 (1985).
Balasubramanian A. et al. Formulation and in-vivo evaluation of niosome encapsulated daunorubicin hydrochloride. Drug Dev and Ind. Pharm. 28:1181 (2002).
Ballie AJ. Et al. Nonionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium-stibogluconate. J. Pharm. Pharmacol. 38: 502 (1986).
Bhaskaran S and Panigrahi L. Formulation and evaluation of niosomes using different nonionic surfactant. Ind. J. Pharm Sci. 63 (2002).
Dufes C. et al. Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to brain.Int. J of Pharm. 285: 77 (2004).
Gopinath D.etal. Ascorbyl palmitate vesicles (Aspasomes): formation, characterization and application. Int. J. Pharm. 271: 95 (2004).
Handjani-vila RM. et al. Dispersion of lamellar phases of nonionic lipids in cosmetic products. Int. J. Cosmetic Sc.1: 303 (1979).
Hofland HEJ. et al. Safety aspect of nonionic surfactant vesicles- a toxicity study related to the physicochemical characteristics of nonionic surfactants. J Pharm.Pharmacol. 44: 287(1992).
Hunter CA. et al. . Vesicular system (niosomes and liposomes) for delivery of sodium stibogluconate in experimental murine visceral leishmaniasis. J Pharm. Pharmacol; 40: 161 (1988).
Kreuter J. Colloidal Drug Delivery System.66; Niosome.Dekker series. P73 , Dekker publication.
Lasic DD. On the thermodynamic stability of liposomes. J. Colloid Interface Sci. 140: 302 (1990).
Luciani A. etal. Glucose receptor MR imaging of tumors: study in mice with PEGylated paramagnetic niosomes. J. Radiology. 231: 135 (2004).
Manosroi A. etal. Characterization of vesicles prepared with various nonionic surfactants mixed with cholesterol. Colloids and surfaces: Biointerfaces. 30:129 (2003).
Murdan S. et al. Sorbitan monostearate/ Polysorbate20 organogels containing niosomes: a delivery vehicle for antigen. European J. Pharm. Sci. 8:177 (1999).
Murdan S. et al. Inverse toroidal vesicles: the precursors of tubular structures in sorbitan monostearate organogels. Euro. Journal of Pharmaceutical Sciences. 6: 22 (1998).
Namdeo A and Jain NK Niosomes as drug carriers. Indian J. Pharm Sci.196; 58: 41.
Naresh AR. et al. Antiinflamatory activity of niosome encapsulated diclofenac sodium in rats. Indian Drugs. 30: 275 (1993).
Naresh RAR. Et al. .Kinetics and tissue distribution of niosomal bleomycin in tumor bearing mice. Ind. J.Pharm. Sci. 58: 230 (1996).
Nasseri B and Florence AT. Some properties of extruded nonionic surfactant micro-tubes. Int. J. Pharm. 254: 11(2003).
Nasseri B and Florence AT. Microtubules formed by capillary extrusion and fusion of surfactant vesicles. Int. J. of Pharm. 266: 91 (2003).
Ozer AY. et al. A novel drug delivery system nonionic surfactant vesicles. Euro. J. Pharm. Biopharm. 37: 75 (1991).
Parthasarathi G. et al. Formulation and in-vitro evaluation of vincristine encapsulated niosomes. Ind. J. Pharm. Sci. 56: 90(1994).
Reddy DN and Udupa N. Formulation and evaluation of oral and transdermal preparation of flurbiprofen and piroxicam incorporated with different carriers. Drug Dev. Ind. Pharm. 19: 843 (1993).
Rogerson A. et al. The distribution of doxorubicin in mice following administration in niosomes. J Pharm. Pharmacol. 40: 337 (1988).
Rogerson A. et al. Adriamycin-loaded niosomes –drug entrapment, stability and release. J. Microencap. 4: 321 (1987).
Satturwar P M. et al. Formulation and evaluation of ketoconazole niosomes. Ind. J. Pharm. Sci. 2: 155 (2002).
Shahiwala A and Misra A. Studies in topical application of niosomally entrapped nimesulide. J. Pharma. Sci. 5: 220.(2002).
Stafford S, Ballie A J and Florence A T.Drug effect on the size of chemically defined nonionic surfactant vesicles. J. Pharm. Pharmacol. 40:26 (1988).
Sternberg B. et al. Geodesic surfactant structures.Nature. 378: 21(1995).
Talsma H. et al. A novel technique for the one step preparation of liposomes and nonionic surfactant vesicles without the use of organic solvent. Liposome formation in a continous gas stream: The bubble method .J. Pharm. Sci. 83: 276 (1999).
Transdermal delivery of ketorolac. Eur.J. Pharm. and Biopharm. 59: 485 (2005).
Uchegbu FI and Vyas PS. Non-ionic surfactant based vesicles (niosomes) in drug delivery.Int.J. Pharm. 172: 33 (1998).
Uchegbu IF and Florence AT. Non-ionic surfactant vesicles (niosomes)-physical and pharmaceutical chemistry. Adv.Colloid Interface Sci. 58: 1(1995).
Varshosaz J.etal. Development and physical characterization of sorbitan monoester niosomes for insuli oral delivery. Drug deliv. 10: 251 (2003).
Yoshida H. et al. Niosomes for oral delivery of peptide drugs. J Control. Rel. 21: 145 (1992).
Yoshioka T and Florence AT. Vesicle (niosome)-in-water-in-oil (v/w/o) emulsion an in-vitro study. Int.J.Pharm. 108: 117 (1994).
Yoshioka T. et al. Preparation and properties of vesicles (niosomes) of sorbitan monoesters (span-20, span-40, span-60, span-80) and a sorbitan triester (span-85). Int. J. Pharm. 105. 1 (1994).
Zhang JQ. Et al. Studies on lung targeted niosomes of carboplatin. European J. Pharm. Sci.; 36 : 303 (2001).
Aggarwal D. et al. Development of topical niosomal preparation of acetazolamide: preparation and evaluation. J. Pharm. Pharmacol. 56(12): 1509 (2004).
Almira I. Blazek-welsh I A and Rhodes G D. Maltodextrin –Based proniosomes.AAPS PharmSciTech. 3 : 36.(2001).
Alsarra AI, Bosela AA, Ahmed MS, and Mahrous M G.Proniosomes as a drug carrier for Arunothayanum P. et al. Investigation into the in vitro/in vivo behaviour of polyhedral niosomes. J. Pharm.Pharmcol. 50(supp): l169 (1998).
Arunothayanun P. et al. The effect of processing variables on the physical characteristics of nonionic surfactant vesicles (niosomes) formed from hexadecyl diglycerol ether. Int. J. Pharm. 201: 7(2000).
Arunothayanun P. et al. Extrusion of niosomes from capillaries: approaches to a pulsed delivery device.J.Cont.Release. 60: 391 (1999).
Azmin MN. et al., The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J Pharm. Pharmacol. 37: 237 (1985).
Baillie AJ. The preparation and properties of niosomes-nonionic surfactant vesicles. J.Pharm. Pharmacol. 37: 863 (1985).
Balasubramanian A. et al. Formulation and in-vivo evaluation of niosome encapsulated daunorubicin hydrochloride. Drug Dev and Ind. Pharm. 28:1181 (2002).
Ballie AJ. Et al. Nonionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium-stibogluconate. J. Pharm. Pharmacol. 38: 502 (1986).
Bhaskaran S and Panigrahi L. Formulation and evaluation of niosomes using different nonionic surfactant. Ind. J. Pharm Sci. 63 (2002).
Dufes C. et al. Glucose-targeted niosomes deliver vasoactive intestinal peptide (VIP) to brain.Int. J of Pharm. 285: 77 (2004).
Gopinath D.etal. Ascorbyl palmitate vesicles (Aspasomes): formation, characterization and application. Int. J. Pharm. 271: 95 (2004).
Handjani-vila RM. et al. Dispersion of lamellar phases of nonionic lipids in cosmetic products. Int. J. Cosmetic Sc.1: 303 (1979).
Hofland HEJ. et al. Safety aspect of nonionic surfactant vesicles- a toxicity study related to the physicochemical characteristics of nonionic surfactants. J Pharm.Pharmacol. 44: 287(1992).
Hunter CA. et al. . Vesicular system (niosomes and liposomes) for delivery of sodium stibogluconate in experimental murine visceral leishmaniasis. J Pharm. Pharmacol; 40: 161 (1988).
Kreuter J. Colloidal Drug Delivery System.66; Niosome.Dekker series. P73 , Dekker publication.
Lasic DD. On the thermodynamic stability of liposomes. J. Colloid Interface Sci. 140: 302 (1990).
Luciani A. etal. Glucose receptor MR imaging of tumors: study in mice with PEGylated paramagnetic niosomes. J. Radiology. 231: 135 (2004).
Manosroi A. etal. Characterization of vesicles prepared with various nonionic surfactants mixed with cholesterol. Colloids and surfaces: Biointerfaces. 30:129 (2003).
Murdan S. et al. Sorbitan monostearate/ Polysorbate20 organogels containing niosomes: a delivery vehicle for antigen. European J. Pharm. Sci. 8:177 (1999).
Murdan S. et al. Inverse toroidal vesicles: the precursors of tubular structures in sorbitan monostearate organogels. Euro. Journal of Pharmaceutical Sciences. 6: 22 (1998).
Namdeo A and Jain NK Niosomes as drug carriers. Indian J. Pharm Sci.196; 58: 41.
Naresh AR. et al. Antiinflamatory activity of niosome encapsulated diclofenac sodium in rats. Indian Drugs. 30: 275 (1993).
Naresh RAR. Et al. .Kinetics and tissue distribution of niosomal bleomycin in tumor bearing mice. Ind. J.Pharm. Sci. 58: 230 (1996).
Nasseri B and Florence AT. Some properties of extruded nonionic surfactant micro-tubes. Int. J. Pharm. 254: 11(2003).
Nasseri B and Florence AT. Microtubules formed by capillary extrusion and fusion of surfactant vesicles. Int. J. of Pharm. 266: 91 (2003).
Ozer AY. et al. A novel drug delivery system nonionic surfactant vesicles. Euro. J. Pharm. Biopharm. 37: 75 (1991).
Parthasarathi G. et al. Formulation and in-vitro evaluation of vincristine encapsulated niosomes. Ind. J. Pharm. Sci. 56: 90(1994).
Reddy DN and Udupa N. Formulation and evaluation of oral and transdermal preparation of flurbiprofen and piroxicam incorporated with different carriers. Drug Dev. Ind. Pharm. 19: 843 (1993).
Rogerson A. et al. The distribution of doxorubicin in mice following administration in niosomes. J Pharm. Pharmacol. 40: 337 (1988).
Rogerson A. et al. Adriamycin-loaded niosomes –drug entrapment, stability and release. J. Microencap. 4: 321 (1987).
Satturwar P M. et al. Formulation and evaluation of ketoconazole niosomes. Ind. J. Pharm. Sci. 2: 155 (2002).
Shahiwala A and Misra A. Studies in topical application of niosomally entrapped nimesulide. J. Pharma. Sci. 5: 220.(2002).
Stafford S, Ballie A J and Florence A T.Drug effect on the size of chemically defined nonionic surfactant vesicles. J. Pharm. Pharmacol. 40:26 (1988).
Sternberg B. et al. Geodesic surfactant structures.Nature. 378: 21(1995).
Talsma H. et al. A novel technique for the one step preparation of liposomes and nonionic surfactant vesicles without the use of organic solvent. Liposome formation in a continous gas stream: The bubble method .J. Pharm. Sci. 83: 276 (1999).
Transdermal delivery of ketorolac. Eur.J. Pharm. and Biopharm. 59: 485 (2005).
Uchegbu FI and Vyas PS. Non-ionic surfactant based vesicles (niosomes) in drug delivery.Int.J. Pharm. 172: 33 (1998).
Uchegbu IF and Florence AT. Non-ionic surfactant vesicles (niosomes)-physical and pharmaceutical chemistry. Adv.Colloid Interface Sci. 58: 1(1995).
Varshosaz J.etal. Development and physical characterization of sorbitan monoester niosomes for insuli oral delivery. Drug deliv. 10: 251 (2003).
Yoshida H. et al. Niosomes for oral delivery of peptide drugs. J Control. Rel. 21: 145 (1992).
Yoshioka T and Florence AT. Vesicle (niosome)-in-water-in-oil (v/w/o) emulsion an in-vitro study. Int.J.Pharm. 108: 117 (1994).
Yoshioka T. et al. Preparation and properties of vesicles (niosomes) of sorbitan monoesters (span-20, span-40, span-60, span-80) and a sorbitan triester (span-85). Int. J. Pharm. 105. 1 (1994).
Zhang JQ. Et al. Studies on lung targeted niosomes of carboplatin. European J. Pharm. Sci.; 36 : 303 (2001).
