Recent Developments and Novel Drug Delivery Strategies for the Treatment of Tuberculosis

DOI:

https://doi.org/10.37285/ijpsn.2019.12.3.2

Authors

  • Yonas Brhane
  • Tesfaye Gabriel
  • Tigist Adane
  • Yemisrach Negash
  • Henok Mulugeta
  • Mulugeta Ayele

Abstract

Tuberculosis (TB) is a contagious infectious illness caused by species having a place with the Mycobacterium tuberculosis complex. The clinical management of tuberculosis still remains a difficult task. Treatment of TB with anti-tubercular drugs becomes the only option available. Hence, the goals of treatment are ensure cure without relapse, prevent death, impede transmission, and prevent emergence of drug resistant strains. This review describes the latest developments and innovative drug delivery strategies for treatment of TB in order to improve the therapeutic efficacy and reduce toxic effect of anti-tubercular agents and enhance patient compliance with concomitant decrease in drug interaction. Among different novel drug delivery systems Niosomes, Liposomes, Dendrimers, Cyclodextrins, Microencapsulation, Alginates and Hydrogels have been described as new drug delivery strategies of anti-tubercular agents. 

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Keywords:

Tuberculosis, Anti-tubercular Drugs, Drug Delivery, Therapeutic efficacy, Toxic effect, Clinical trials

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Published

2019-05-31

How to Cite

1.
Brhane Y, Gabriel T, Adane T, Negash Y, Mulugeta H, Ayele M. Recent Developments and Novel Drug Delivery Strategies for the Treatment of Tuberculosis. Scopus Indexed [Internet]. 2019 May 31 [cited 2024 May 20];12(3):4524-30. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/298

Issue

Section

Review Articles

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