Development of nanoparticles for the Novel anticancer therapeutic agents for Acute Myeloid Leukemia
Development of nanoparticles for the Novel anticancer therapeutic agents for AML
Acute myeloid leukaemia is becoming more predominant in blood cancer in geriatrics people groups. In 2017, four new therapeutic candidates have been approved by the FDA: Enasidenib, CPX 351, Midostaurin, and Gemtuzumab ozogamicin; with the approval of Venetoclax and Daurismo, additional advances were achieved in 2018. Ivosidenib and gilteritinib were also accepted as single-agent therapy in persistent and recurrent AML 2018. Most of the anticancer drugs belong to Biopharmaceutical classification system-II (BSC), and BCS class-IV has poor bioavailability because of solubility issues. We will overcome this problem by preparing nanoparticles of this drug by using different nanoparticle preparation methods.
Keywords:Acute myeloid leukemia, Nanoparticle, Anticancer therapeutic agents, FLT3 inhibitors, Ionic gelation, emulsion-Solvent evaporation, Double Emulsion
How to Cite
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