Preparation and Characterization of Pitavastatin Calcium Loaded Biodegradable Porous Starch as Carrier Platform for Drug Delivery

DOI:

https://doi.org/10.37285/ijpsn.2023.16.6.4

Authors

  • Bhushan K. Marathe Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research
  • Gaurav Patil Gaurav Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research
  • Vijay Dhangar Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research
  • Vivekanand K. Chatap Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research

Abstract

Introduction: Poor solubility and low oral bioavailability are major obstacles to the development of efficient drug delivery approaches. Numerous chemical entities fall into the biopharmaceutics classification system II (BCS II) class, categorized by low solubility and high permeability. Consequently, finding alternative solutions for improving drug efficacy becomes crucial. Hence, this study aims to formulate biodegradable porous acetostarch (BPSa) and biodegradable porous ethostarch (BPSe) carriers to augment the solubility profile of the poorly soluble drug candidate pitavastatin calcium (PTC).

Method: The biodegradable carriers (BPSa and BPSe) were prepared using the solvent exchange method. Then the PTC was loaded into the prepared carriers (PTC@BPSa and PTC@BPSe) using the passive drug loading procedure. Moreover, the obtained drug-carrier conjugates were evaluated using physiochemical evaluation techniques such as Fourier transform infrared spectroscopy (FTIR), x-ray powder diffraction (XRPD), and differential scanning calorimetry (DSC). Additionally, the surface morphology and drug release characteristics are determined.

Result: The experimental findings exhibited high drug content with 75.45% and 71.81% for PTC@BPSa and PTC@BPSe, respectively. The SEM analysis of the prepared conjugates demonstrates asymmetrical morphology with cracks between particles, indicating porous nature of the carriers. As a result of this, PTC@BPSa and PTC@BPSe exhibited modified drug release patterns, with cumulative releases of 78.63% and 78.50%, respectively.

Conclusion: The biodegradable porous carriers (BPSa and BPSe) effectively improve the dissolution pattern of PTC, by addressing the challenges associated with poor solubility. This study offers valuable insights into the potential of these biodegradable porous carriers as effective drug delivery platforms for increasing the efficacy of limited soluble medications.

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Keywords:

Poorly solubility, Biodegradable porous starch, Carrier, Solvent exchange method, Pitavastatin calcium

Published

2023-11-15

How to Cite

1.
Bhushan K. Marathe, Gaurav GP, Vijay Dhangar, Vivekanand K. Chatap. Preparation and Characterization of Pitavastatin Calcium Loaded Biodegradable Porous Starch as Carrier Platform for Drug Delivery: . Scopus Indexed [Internet]. 2023 Nov. 15 [cited 2024 Feb. 26];16(6):7049-56. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/3767

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Section

Research Articles

References

Yee LL, Wright EA. Pitavastatin Calcium: Clinical Review of a New Antihyperlipidemic Medication. Clin Ther. 2011;33(8):1023-1042.

Teaima MH, Abdel-Haleem KM, Osama R, El-Nabarawi MA, Elnahas OS. A promising single oral disintegrating tablet for co-delivery of pitavastatin calcium and lornoxicam using co-processed excipients: formulation, characterization and pharmacokinetic study. Drug Des Devel Ther. Published online 2021:4229-4242.

Ashfaq M, Shah S, Rasul A, et al. Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS). Pharmaceutics. 2022;14(3):482.

Poovi G, Damodharan N. Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs. Future J Pharm Sci. 2018;4(2):191-205.

Bhalani DV, Nutan B, Kumar A, Singh Chandel AK. Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines. 2022;10(9):2055.

Savjani KT, Gajjar AK, Savjani JK. Drug solubility: importance and enhancement techniques. Int Sch Res Not. 2012;2012.

Kumar S, Singh P. Various techniques for solubility enhancement: An overview. The Pharma Innovation. 2016;5(1, Part A):23.

Fong SYK, Ibisogly A, Bauer-Brandl A. Solubility enhancement of BCS Class II drug by solid phospholipid dispersions: Spray drying versus freeze-drying. Int J Pharm. 2015;496(2):382-391.

Shirsath NR, Goswami AK. Design and Development of Solid Dispersion of Valsartan by a Lyophilization Technique: A 32 Factorial Design Approach. Micro Nanosyst. 2021;13(1):90-102.

Khadka P, Ro J, Kim H, et al. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm Sci. 2014;9(6):304-316.

Chen H, Khemtong C, Yang X, Chang X, Gao J. Nanonization strategies for poorly water-soluble drugs. Drug Discov Today. 2011;16(7-8):354-360.

Sugandha K, Kaity S, Mukherjee S, Isaac J, Ghosh A. Solubility Enhancement of Ezetimibe by a Cocrystal Engineering Technique. Cryst Growth Des. 2014;14(9):4475-4486.

Zawar L, Patil G, Shirsath N, Bafna P. Nanosuspension: A New Horizon in the Drug Delivery System. Int J Pharm Sci NanotechnologyIJPSN. 2022;15(5):6169-6179.

Chaudhary A, Nagaich U, Gulati N, Sharma VK, Khosa RL, Partapur MU. Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. J Adv Pharm Educ Res. 2012;2(1):32-67.

Alam MA, Ali R, Al-Jenoobi FI, Al-Mohizea AM. Solid dispersions: a strategy for poorly aqueous soluble drugs and technology updates. Expert Opin Drug Deliv. 2012;9(11):1419-1440.

Tella JO, Adekoya JA, Ajanaku KO. Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review. R Soc Open Sci. 2022;9(6):220013.

Ali MT, Fule R, Sav A, Amin P. Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine. AAPS PharmSciTech. 2013;14(3):919-926.

Apriyanto A, Compart J, Fettke J. A review of starch, a unique biopolymer – Structure, metabolism and in planta modifications. Plant Sci. 2022;318:111223.

Kumar L, Brennan MA, Mason SL, Zheng H, Brennan CS. Rheological, pasting and microstructural studies of dairy protein–starch interactions and their application in extrusion-based products: A review. Starch-Stärke. 2017;69(1-2):1600273.

Chibuogwu C, Amadi B, Anyaegbunam Z, Emesiani B, Ofoefule S. Application of starch and starch derivatives in pharmaceutical formulation. Chemical Properties of Starch. 2020 Mar 11:1-0.

Nawaz H, Waheed R, Nawaz M, Shahwar D. Physical and chemical modifications in starch structure and reactivity. Chemical properties of starch. 2020 Mar 11;9:13-35.

Jiang T, Wu C, Gao Y, et al. Preparation of novel porous starch microsphere foam for loading and release of poorly water soluble drug. Drug Dev Ind Pharm. 2014;40(2):252-259.

Rostamabadi H, Falsafi SR, Jafari SM. Starch-based nanocarriers as cutting-edge natural cargos for nutraceutical delivery. Trends Food Sci Technol. 2019;88:397-415.

Vo CLN, Park C, Lee BJ. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. Eur J Pharm Biopharm. 2013;85(3):799-813.

Labib G. Overview on zein protein: A promising pharmaceutical excipient in drug delivery systems and tissue engineering. Expert Opin Drug Deliv. 2018;15(1):65-75.

Chatap VK, Patil SD. In-vitro and in-vivo consideration of repaglinide immediate-release tablet: assessment of porous acetostarch as a promising carrier for dissolution rate enhancement. Food Sci Technol. 2016;4(4):78-88.

Wu C, Wang Z, Zhi Z, Jiang T, Zhang J, Wang S. Development of biodegradable porous starch foam for improving oral delivery of poorly water soluble drugs. Int J Pharm. 2011;403(1):162-169.

Nikam AN, More MP, Pandey AP, Patil PO, Patil AG, Deshmukh PK. Design and development of thiolated graphene oxide nanosheets for brain tumor targeting. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020 Jul 2;69(10):611-21.

El Maghraby GM, Osman MA, Abd-Elrahman HE, Elsisi AE. Self emulsifying liquisolid tablets for enhanced oral bioavailability of repaglinide: in vitro and in vivo evaluation. Journal of Applied Pharmaceutical Science. 2014 Sep 27;4(9):012-21.

Teaima MH, Abdel-Haleem KM, Osama R, El-Nabarawi MA, Elnahas OS. A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam Using Co-Processed Excipients: Formulation, Characterization and Pharmacokinetic Study. Drug Des Devel Ther. 2021;15:4229-4242.