Antiobesity Evaluation of Novel Series of 3-(5-(Substituted Benzylidene)-2-(Substituted Phenyl)-4-Oxothiazolidin-3-yl)-2-(Substituted Phenyl) Thiazolidin-4-ones
DOI:
https://doi.org/10.37285/ijpsn-aktu.2022-23Abstract
Introduction: Obesity is a leading disease in developed as well as developing countries due to sedentary lifestyle. Enormous research studies have been ongoing for development of novel antiobesity drugs because orlistat is the only drug approved by Food and Drug Administration (FDA).
Methods: In the present study, a series of 5-arylidene thiazolidin_4-ones (5a-i) were synthesized by Knoevenagel condensation of corresponding thiazolidinone (4a-e) and aromatic aldehydes in presence of anhydrous sodium acetate.
Result: The structures of the synthesized compounds were confirmed by spectral
data i.e. IR and 1H-NMR. All the newly synthesized compounds were evaluated for
their antiobesity activity.
Conclusion: All the synthesized compounds significantly reduced the body weight gain. Among all the compounds, 5h and 5i were found to most active, almost comparable to orlistat.
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Keywords:
5-Arylidene thiazolidin-4-one, anti-obesity activity, aromatic aldehydes, Knoevenagel condensation, OrlistatPublished
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