Pulsatile Drug Delivery Systems: An Overview

DOI:

https://doi.org/10.37285/ijpsn.2009.2.3.3

Authors

  • Ramesh D. Parmar
  • Rajesh K. Parikh
  • G. Vidyasagar
  • Dhaval V. Patel
  • Chirag J. Patel
  • Biraju D. Patel

Abstract

Pulsatile  Drug  Delivery  Systems  are  gaining  a  lot  of  interest  as  they  deliver  the  drug  at  the  right  place  at  the  right  time  and  in  the  right  amount,  thus  providing  spatial  and  temporal  delivery  and  increasing  patient  compliance.  These  systems  are  designed  according  to  the  circadian  rhythm  of  the  body.  The  principle  rationale  for  the  use  of  pulsatile  release  of  the  drugs is where  a  constant  drug  release  is  not  desired.  A  pulse  has  to  be  designed  in  such  a  way  that  a  complete  and  rapid  drug  release  is  achieved  after  the  lag  time.  Various  systems  like  capsular  systems,  osmotic  systems,  single-  and  multiple-unit  systems  based  on  the  use  of  soluble  or  erodible  polymer  coating  and  use  of  rupturable  membranes  have  been  dealt  with  in  the  article.  It  summarizes  the  latest  technological  developments,  formulation  parameters,  and  release  profiles  of  these  systems.  These  systems  are  beneficial  for  the  drugs  having  chronopharmacological  behavior  where  night  time  dosing  is  required,  such  as  anti-arhythmic  and  anti-asthmatic.

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Keywords:

Pulsatile, Rupturable, Erodible, Osmotic

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Published

2009-11-30

How to Cite

1.
Parmar RD, Parikh RK, G. Vidyasagar, Patel DV, Patel CJ, Patel BD. Pulsatile Drug Delivery Systems: An Overview. Scopus Indexed [Internet]. 2009 Nov. 30 [cited 2024 Jul. 2];2(3):605-14. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/518

Issue

Vol. 2 No. 3 (2009): October-December 2009

Section

Review Articles
Crossref
Scopus
Google Scholar
Europe PMC

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