Piperine- Review of Advances in Pharmacology

DOI:

https://doi.org/10.37285/ijpsn.2009.2.3.4

Authors

  • Amritpal Singh
  • Sanjiv Duggal

Abstract

Piperine, an alkaloid, is found in Piper longum L. and Piper nigrum L. The plants containing piperine are widely used in Alternative and Complementary Therapies for curing an array of disorders. Piperine obtained from botanical sources is about 98% pure. It is produced in the laboratory for chemical and medical purposes. Piperine is helpful in reducing inflammation, improving digestion, and relieving pain and asthma. It is reported to improve the production of serotonin, it may relieve stomach ulcerations. It improves the bioavailability of other nutritive substances including beta carotene, curcumin, selenium, pyroxidine, glucose, and amino acids. Extensive data has been complied in favour of piperine in a wide range of pharmacological studies. The review analyses recent advances in pharmacology research on piperine.

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Keywords:

Piperine, bioavailability, pharmacology

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Published

2009-11-30

How to Cite

1.
Singh A, Duggal S. Piperine- Review of Advances in Pharmacology. Scopus Indexed [Internet]. 2009 Nov. 30 [cited 2024 Jul. 2];2(3):615-20. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/528

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Section

Review Articles

References

Choi BM, Kim SM, Park TK, Li G, Hong SJ, Park R, Chung HT, Kim BR. Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells. J Nutr Biochem. 18(9): 615-622 (2007).

Dogra RK, Khanna S, Shanker R. Immunotoxicological effects of piperine in mice. Toxicology, 196(3): 229-236 (2004).

Duessel S, Heuertz RM, Ezekiel UR. Growth inhibition of hman colon cancer cells by pants compounds. Clin Lab Sci. 21(3):151-157 (2008).

DurgaprasadS, Pai CG, Vasanthkumar, Alvres JF, Namitha S. A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. Indian J Med Res. 122(4): 315-318 (2005).

Jintanaporn Wattanathorn, Pennapa Chonpathompikunlert, Supaporn Muchimapura, Aroonsri Priprem, Orathai Tankamnerdthai. Piperine, the potential functional food for mood and cognitive disorders, Food and Chemical Toxicology 46( 9): 3106-3110 (2008).

Kasibhatta R, Naidu MU. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomized, crossover, placebo-controlled study. Drugs R D, 8(6): 383-391 (2007).

Kim SH, Lee YC. Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model. J Pharm Pharmacol, 61(3): 353-359 (2009).

Kulkarni SK, Bhutani MK, Bishnoi M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl). 201(3): 435-442 (2008).

Lambert JD, ong J, Kim DH, Mishim VM, Yang CS. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr. 134(8), 1948-52 (2004).

Li M, Liu Z. In vitro effect of Chinese herb extracts on caries-related bacteria and glucan. J Vet Dent. 25(4): 236-239 (2008).

Manoharan S, Balakrishnan S, Menon VP, Alias LM, Reena AR. Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J. 50 (2): 139-146 (2009).

Matsuda H, Ninomiya K, Morikawa T, Yasuda D, Yamaguchi I, Yoshikawa M. Protective effects of amide constituents from the fruit of Piper chaba on D- galactosamine/TNF-alpha-induced cell death in mouse hepatocytes. Bioorg Med Chem Lett. 18(6):2038-42 (2008).

Mohit Kumar Bhutani , Mahendra Bishnoi , Shrinivas K. Kulkarni. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacology, Biochemistry and Behavior 92:39–43 (2009).

Neelima Pathak, Shashi Khandelwal. Cytoprotective and immunomodulating properties of piperine on murine splenocytes: An in vitro study. European Journal of Pharmacology 576:160–170 (2007).

Nirala SK, Bhadauria M, Mathur R, Mathur A. Influence of alpha-tocopherol, propolis and piperine on therapeutic potential of tiferron against beryllium induced toxic manifestations. J Appl Toxicol. 28(1): 44-54 (2008).

Ononiwu IM, Ibeneme CE, Ebong OO. Effects of piperine on gastric acid secretion in albino rats. Afr J Med Sci. 31(4): 293-295 (2002).

Panda S, Kar A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm Metab Res. 35(9): 523-526 (2003).

Park BS, Son DJ, Park YH, Kim TW, Lee SE. Antiplatelet effects of acidamides isolated from the fruits of Piper longu L Phytomedicine. 14(12):853-5 (2007).

Pattanaik S, Hota D, Prabhakar P, Pandhi P. Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res. 12 (2009)

Pawinee Piyachaturawat and Chmpol Pholpramool. Enhancement of fertilization by Piperine in Hamsters.Cell Biology International, 21(7): 405-409 (1997).

Pradeep CR, Kuttan G. Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. Int Immunopharmacol, 4(14): 1795-1803 (2004).

Sarvesh Kumar, Vandana Singhal, Reema Roshan, Amit Sharma, Gopal Waman Rembhotkar, Balaram Ghosh. Piperine inhibits TNF-α induced adhesion of neutrophils to endothelial monolayer through suppression of NF-κB and IκB kinase activation. Journal of Pharmacology, 575: 177–186 (2007).

Selvendiran K, Banu SM, Sakthisekaran D. Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis. Mol Cell Biochem, 268(1-2): 141-147 (2005b).

Selvendiran K, Padmavathi R, Magesh V, Sakthisekaran D. Preliminary study on inhibition of genotoxicity by piperine in mice. Fitoterapia. 76(3-4): 296-300 (2005a).

Singh, YN. Kava an overview. J. Ethanopharmacol. 37: 18–45 (1992).

Song Li, Che Wang, Minwei Wang, Wei Li, Kinzo Matsumoto, Yiyuan Tang. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sciences 80:1373–1381 (2007).

Taqvi SI, Shah AJ, Gilani AH. Blood pressure lowering and effects of piperine. J. Cardiovasc Pharmacol. 52(5): 452-458 (2008).

Veerareddy PR, Vobalaboina V, Nahid A. Formulation and evaluation of oil-in-water emulsions of piperine in visceral leishmaniasis. Pharmazie, 59(3): 194-197 (2004).

Vijayakumar RS, Nalini N. Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats. J Basic Clin Physiol Pharmacol. 17(2):71-86 (2006).

Vijayakumar RS, Surya D, Nalini N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep. 9(2): 105-110 (2004).

Vladimir Badmaev, Muhammed Majeed, Edward P.N. Piperine, An alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Nutrition Research, 19(3): 381-388 (1999).

Vladimir Badmaev, Muhammed Majeed, Lakshmi Prakash. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J. Nutr. Biochem. 11: 109-113 (2000).

Volak LP, Ghirmai S, Cashman JR, Court MH. Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos. 36(8): 1594-1605 (2008).

Wongpa S, Himakoun L, Soontornchai S, Temchargen P. Antimutagenic effects of piperine on cyclophosphamde-induced chromosome aberrations in rat bone marrow cells. Asian Pac J Cancer Prev, 8(4): 623-627 (2007).

Zhao JQ, Du GZ, Xiong YC, Wen YF, Bhadauria M, Nirala SK. Attenuation of beryllium induced he