Synthesis and Pharmacological Evaluation of New Indolyl-oxadiazoles as Anticonvulsant Agents

DOI:

https://doi.org/10.37285/ijpsn.2009.2.3.10

Authors

  • Harish Rajak
  • Ravichandran Veerasamy
  • Arun Kumar Gupta
  • Murli Dhar Kharya
  • Pradeep Mishra

Abstract

The search for better anticonvulsant drug and the importance of 2,5-disubstituted 1,3,4-oxadiazoles and indole as anticonvulsant pharmacophores, prompted us to design, synthesize and evaluate a series of differently substituted 1,3,4-oxadiazoles for their potential anticonvulsant activity. The structures of the compounds were elucidated by elemental and spectral (IR, 1H NMR, 13C NMR and MS) analyses. Most of the test compounds demonstrated appreciable anticonvulsant activities in maximal electroshock seizure (MES) and subcutaneous pentylenetrtrazole (scPTZ) models.

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Keywords:

Oxadiazole, Indole, Anticonvulsant activity

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Published

2009-11-30

How to Cite

1.
Rajak H, Veerasamy R, Gupta AK, Kharya MD, Mishra P. Synthesis and Pharmacological Evaluation of New Indolyl-oxadiazoles as Anticonvulsant Agents. Scopus Indexed [Internet]. 2009 Nov. 30 [cited 2024 Jul. 2];2(3):661-6. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/638

Issue

Vol. 2 No. 3 (2009): October-December 2009

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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