Solid Dispersion Incorporated Indomethacin Oro- Dispersible Tablet
DOI:
https://doi.org/10.37285/ijpsn.2024.17.5.4Abstract
Aim: This study aimed to enhance the dissolution profile of indomethacin by formulating oro-dispersible tablets, using the Solid Dispersion technique and PEG 6000 and PVP K-30 as carriers.
Method: Solid Dispersion (SD) of indomethacin were prepared using the kneading method. Pre-compression studies include evaluating granules' density and flow properties, while post-compression studies assessed tablet properties such as hardness, friability, wetting time, dissolution, drug content and material interactions.
Result: All pre- and post-compressional parameters were found within pre-determined limits. FTIR indicated no remarkable interaction between the polymers and the drug in the SDs. The dissolution study showed that the formulation with a 1:1 ratio of indomethacin to PVP K-30 and PEG 6000 exhibited the fastest dissolution rate, releasing 99.53% of the drug within 15 minutes.
Conclusion: The study successfully formulated oro-dispersible tablets of indomethacin using the SD technique with PVP K-30 and PEG 6000 as carriers. These SD granules exhibited excellent flow properties. Whereas tablets showed appropriate physical characteristics, and rapid dissolution rates, which can improve effectiveness of the drugs like indomethacin. This approach offers a promising solution for patients who have trouble taking tablets.
Downloads
Metrics
Keywords:
Mouth dissolving tablet, Polyvinyl Pyrrolidone K-30, Poly-ethylene Glycol 6000, oro-dispersible tablets, Kneading Method, Fast Dissolving Tablet
Published
How to Cite
Issue
Section
References
Sayeed A, Md Hamed M, Rafiq M. Formulation and in vitro evaluation of mouth dissolving tablets of Carvedilol by direct compression methods. Res J Pharm Technol. 2012;5(12):1525-1531.
Fini A, Bergamante V, Ceschel GC, Ronchi C, de Moraes CAF. Fast dispersible/slow releasing ibuprofen tablets. Eur J Pharm Biopharm. 2008;69(1):335-341.
Atneriya U, Kapoor D, Sainy J, Maheshwari R. In vitro profiling of fenofibrate solid dispersion mediated tablet formulation to treat high blood cholesterol. Ann Pharm Françaises. 2023;81(2):284-299.
Parhi R. Improvement of Dissolution Rate of Indomethacin From Fast Dissolving Tablets. Indones J Pharm. 2014;25(3):198.
Bhalerao RA, Kakade SS, Bhosale A V, Bhondve RR, Beldar AR, Biradar PS. Formulation and evaluation mouth dissolving tablets of solid dispersion of fenofibrate. 12(8):3124-3152.
Khatry S, Sood N, Arora S. Surface Solid Dispersion – A Review. Int J Pharm Sci Nanotechnol. 2013;6(1):1915-1925.
Ramesh Y, Raghu murthy V, Nagarjuna S, Reddy Viswanatha M, Sudheer M, Manikanta M. Development and in vitro evaluation of fast dissolving tablets of imipramine. Int J Res Pharm Sci. 2011;2(3):344-347. doi:10.5958/2231-5691.2016.00003.4
Nikam VK, Shete SK, Khapare JP. Most promising solid dispersion technique of oral dispersible tablet. Beni-Suef Univ J Basic Appl Sci. 2020;9(1).
Haque I, Kumar R, Narayanaswamy V, Hoque M. Formulation and Evaluation of Montelukast Sodium Fast Dissolving Tablets. Asian J Pharm Res. 2016;6(3):159.
Adil V, Rajput D, Jain S, Kapoor V, Gupta N. Formulation and development of lamotrigine fast dissolving tablet by enhancing its solubility through solid dispersion. Res J Pharm Technol. 2021;14(2):873-878.
Shinde S, Mundhada D, Mujoriya R. Formulation and Evaluation of Fast Dissolving Tablet of Drug Used In the Treatment of Motion Sickness. Asian J Res Pharm Sci. 2015;5(3):181.
Ali MS, Ahmad S, Alam MS, Alam N, Alam MI. Trend in fast dissolving tablets: An overview. Res J Pharm Technol. 2016;9(1):69-78.
Das PS, Verma S, Saha P. Fast Dissolving Tablet Using Solid Dispersion Technique: a Review. Int J Curr Pharm Res. 2017;9(6):1.
Aljimaee YHM, El-Helw ARM, Ahmed OAA, El-Say KM. Development and optimization of carvedilol orodispersible tablets: Enhancement of pharmacokinetic parameters in rabbits. Drug Des Devel Ther. 2015;9:1379-1392.
Abd-El Bary A, Louis D, Sayed S. Olmesartan medoxomil surface solid dispersion-based orodispersible tablets: Formulation and in vitro characterization. J Drug Deliv Sci Technol. 2014;24(6):665-672.
Cilurzo F, Musazzi UM, Franzé S, Selmin F, Minghetti P. Orodispersible dosage forms: biopharmaceutical improvements and regulatory requirements. Drug Discov Today. 2018;23(2):251-259.
Kranthi Kumar Reddy M, Narasimha Rao B, Ravindra Reddy K. Study on Effect of Excipients in Enhancing the Solubility of Nateglinide by Solid Dispersions. Pharm Res. 2012;2(4):144-147.
Christopher Vimalson D, Parimalakrishnan S, Jeganathan NS, Anbazhagan S. Solid dispersion technique to enhance the solubility and dissolution of febuxostat an BCS class II drug. Int J Appl Pharm. 2019;11(1):241-246.
Jain SK, Shukla M, Shrivastava V. Development and in vitro evaluation of ibuprofen mouth dissolving tablets using solid dispersion technique. Chem Pharm Bull. 2010;58(8):1037-1042.
Malkawi R, Malkawi WI, Al-Mahmoud Y, Tawalbeh J. Current Trends on Solid Dispersions: Past, Present, and Future. Adv Pharmacol Pharm Sci. 2022;2022. doi:10.1155/2022/5916013
Elkhodairy KA, Hassan MA, Afifi SA. Formulation and optimization of orodispersible tablets of flutamide. Saudi Pharm J. 2014;22(1):53-61.
Sammour OA, Hammad MA, Megrab NA, Zidan AS. Formulation and optimization of mouth dissolve tablets containing rofecoxib solid dispersion. AAPS PharmSciTech. 2006;7(2):1-9.
Gaber DA, Alnwiser MA, Alotaibi NL, et al. Design and optimization of ganciclovir solid dispersion for improving its bioavailability. Drug Deliv. 2022;29(1):1836-1847.
Yadav P, Patel P, Das P, Deshmukh N, Pillai S. Formulation and evaluation of pioglitazone HCL fast dissolving tablet using solid dispersion. Res J Pharm Technol. 2018;11(12):5313-5318. doi:10.5958/0974-360X.2018.00967.8
Modi A, Tayade P. Enhancement of dissolution profile by solid dispersion (kneading) technique. AAPS PharmSciTech. 2006;7(3):1-6.
Husain M, Agnihotri V V., Goyal SN, Agrawal YO. Development, optimization and characterization of hydrocolloid based mouth dissolving film of Telmisartan for the treatment of hypertension. Food Hydrocoll Heal. 2022;2(March):100064. doi:10.1016/j.fhfh.2022.100064
Alsalhi MS, Chan KLA. Amino acid hydrotropes to increase the solubility of indomethacin and carbamazepine in aqueous solution. Int J Pharm. 2022;617:121591.
"Quest Calculate™ Phosphate Buffer (pH 5.8 to 7.4) Preparation and Recipe." AAT Bioquest, Inc., 6 Feb. 2024
Mohammadi H, Kumar H V., Roshan S, Bhikshapathi DVRN. Development and Evaluation of Fast Disintegrating Tablets of Lornoxicam Solid Dispersions. Int J Pharm Sci Nanotechnol. 2019;12(4):4585-4592.
Raj AL, Kumar YS. Formulation, Characterization and Solubility Enhancement of Manidipine Solid Dispersions. Int J Pharm Sci Nanotechnol. 2019;12(2):4453-4460.
Tie H, Wang Y, Shang Y, Li M, Wei X, Wang Z. Fabrication of pH-dependent solid dispersion for oral colon-targeted delivery of notoginsenoside R1 and its protective effects on ulcerative colitis mice. Heliyon. 2023;9(9):e20280.
Elkanayati RM, Omari S, Youssef AAA, et al. Multilevel categoric factorial design for optimi-zation of raloxifene hydrochloride solid dispersion in PVP K30 by hot-melt extrusion technology. J Drug Deliv Sci Technol. 2024;92:105362.
Zaki RM, Alfadhel M, DevanathaDesikan Seshadri V, et al. Fabrication and characterization of orodispersible films loaded with solid dispersion to enhance Rosuvastatin calcium bioavailability. Saudi Pharm J. 2023;31(1):135-146.
Basu B, Aviya KR, Bhattacharya A. Development and characterization of mouth dissolving tablets of prednisolone. J Pharm Investig. 2014;44(2):79-102. doi:10.1007/s40005-013-0107-y
A. Abdulqader A, B. H.Al-Khedairy E. Formulation and Evaluation of Fast Dissolving Tablets of Taste-Masked Ondansetron Hydrochloride by Solid Dispersion. Iraqi J Pharm Sci ( P-ISSN 1683 - 3597 , E-ISSN 2521 - 3512). 2017;26(1):50-60.
Ahmed M, Kumar R, Narayanaswamy V, Haque I, Hoque M. Formulation and Evaluation of Fast Dissolving Tablets of Doxazosin Mesylate. Asian J Pharm Res. 2016;6(3):131.
Sarkar T, Raju T, Patil BS, Mohite RR, Nitalikar MM. Formulation and in-vitro evaluation of fast dissolving tablets using pregabalin as a model drug. Res J Pharm Technol. 2015;8(2):154-160.
Nath Sharma A, Kumar Upadhyay P, Bajpai M, et al. Formulation and evaluation of fast dissolving tablets of Nimesulide and Paracetamol. Mater Today Proc. Published online 2023.
Mhetre RL, Kadam PS, Gadhire PH, Lajurkar G, Kagade A, Dhole SN. Formulation and Evaluation of Naproxen Orodispersible Tablets. Int J Pharm Sci Nanotechnol. 2022;15(4):6055-6060.
Panda BP, Patro C., Kesharwani D, Rao ME. Optimization of Diclofenac Sodium Orodispersible Tablets with Natural Disintegrants using Response Surface Methodology. Int J Pharm Sci Nanotechnol. 2013;6(3):2172-2180.
Brniak W, Jachowicz R, Pelka P. The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets (ODTs). Saudi Pharm J. 2015;23(4):437-443.
Patil R, Patil N, Patil A, et al. Preparation and Evaluation of Fast Dissolving Tablet Tramadol Hydrochloride. Asian J Pharm Technol. 2016;6(3):183.
Izmalkov SN, Bratiychuk AN, Galeev FS, Usov AK, Kuropatkin G V. Comparative Characteristic of Strength of Different Approaches to Cement Fixation of Therapeutic Component of Hip Joint in Endoprosthesis from Computer Modeling Positions. Res J Pharm Technol. 2017;10(12):4474.
Abd Elbary A, Ali AA, Aboud HM. Enhanced dissolution of meloxicam from orodispersible tablets prepared by different methods. Bull Fac Pharmacy, Cairo Univ. 2012;50(2):89-97.
Sakure K, Kumari L, Badwaik H. Development and evaluation of solid dispersion based rapid disintegrating tablets of poorly water-soluble anti-diabetic drug. J Drug Deliv Sci Technol. 2020; 60:101942.
Eisa AM, El-Megrab NA, El-Nahas HM. Formulation and evaluation of fast dissolving tablets of haloperidol solid dispersion. Saudi Pharm J. 2022;30(11):1589-1602.
Dua K, Pabreja K, Ramana M V. Enhancement of dissolution behavior of aceclofenac by complexation with β-cyclodextrin-choline dichloride copreci-pitate. J Dispers Sci Technol. 2011;32(10):1477-1484.
Soumya MS, Chowdary YA, Madhuri A, et al. Formulation and Invitroevaluation of fast dissolving tablets of flecainide acetate. Int J Pharm Pharm Sci. 2013;5(2):555-560.
