Recent Advances in Nanocapsule: Types, Preparation Methods and Characterizatio
DOI:
https://doi.org/10.37285/ijpsn.2019.12.4.2Abstract
Nanocapsules are submicroscopic colloidal drug carrier systems consist of a liquid/solid core in which the drug, gene, protein, and other substances are incorporated into the interior cavity that is surrounded by a distinctive polymeric membrane. Polymers like collagen, albumin, and gelatin are mainly using polymers in nanocapsule formulations. Nanocapsules can serve as nano-sized drug carriers to achieve controlled release as well as efficient drug targeting. The process is used to improve the poor aqueous drug solubility, taste, stabilizing drugs by protecting the molecule from the environment, providing the desired pharmacokinetic profile, allowing controlled release, as well as facilitating oral administration. Capsules are generally prepared between the range of 100 and 1000 nm. Their release and degradation properties largely depend on the composition and the structure of the capsule walls. The dispersion stability of nanocapsules determined by the surfactant, nature of the outer coating. This review describes various facts of nanocapsule drug delivery systems in relation to the method of formulation, characterization, potential benefits and risks, and pharmaceutical applications in drug delivery.
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Keywords:
Nanocapsule, drug delivery, drug loading, dispersion, polymers
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Published
2019-07-31
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1.
Thenrajan RS. Recent Advances in Nanocapsule: Types, Preparation Methods and Characterizatio. Scopus Indexed [Internet]. 2019 Jul. 31 [cited 2024 Nov. 5];12(4):4573-9. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/305
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Review Articles
References
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Ai H and Gao J (2004). Size-controlled polyelectrolyte nanocapsules via layer-by-layer self-assembly. J Mat Sci, 39: 1429-1432.
Anton N, Saulnier P, Gaillard C, Porcher E, Vrignaud S and Benoit JP (2009). Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules. Langmuir, 25(19): 11413-11419.
Ashwini Kumar G, Amit Bhat and Shoba Rani (2010). Preparation and characterization of diltiazem nanocapsules: Influence of various polymers. Asian J Pharm, 4(3): 224-234.
Bhardwaj A, Lalit Kumar and Veenu K (2011). Colloidal drug delivery systems: A future prospective for treatment of tuberculosis. American J PharmTech Res, 1(3): 102-123.
Bhatia S (2016). Natural Polymer Drug Delivery Systems. Chapter 2 Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications. Springer International Publishing, Switzerland, 34.
Blaiszik BJ, Sottos NR and White SR (2008). Nanocapsules for self-healing materials. Comp Sci Tech, 68(3-4): 978-986.
Bolhassani A, Javanzad S, Saleh T, Mehrdad Hashemi, Mohammad Reza Aghasadeghi and Seyed Mehdi Sadat (2014). Polymeric nanoparticles. Hum Vaccin Immunother, 10(2): 321-332.
Carbone C, Musumeci T, Lauro MR and Puglisia G (2015). Eco-friendly aqueous core surface-modified nanocapsules. Colloids Surf B Biointerfaces, 125: 190-196.
Cauchetier E, Deniau M, Fessi H, Astier A and Paul M (2003). Atovaquone-loaded nanocapsules: Influence of the nature of the polymer on their in vitro characteristics. Int J Pharm, 250(1): 273-281.
Couvreur P, Barratt G, Fattal E, Legrand P and Vauthier C (2002). Nanocapsule technology: A review. Crit Rev Ther Drug Carrier Syst, 19(2): 99-134.
D’Souza S (2014). A Review of in vitro drug release test methods for nano-sized dosage forms. Advances in Pharmaceutics, pp-1-12. https://doi.org/10.1155/2014/304757.
De Melo NF, Grillo R, Guilherme VA, De Araujo DR, De Paula E, Rosa AH and Fraceto LF (2011). Poly (Lactide-co-Glycolide) Nanocapsules containing benzocaine: Influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity. Pharm Res, 28(8): 1984-1994.
Dineshkumar B, Krishnakumar K, Anish John, David Paul, Joseph Cherian and Panayappan L (2013). Nanocapsules: A novel nano-drug delivery system. Int J Res Drug Delivery, 3(1): 1-3.
Eduardo A. Bender, Márcia D. Adorne, Letícia M. Colomé, Dulcinéia S.P. Abdalla, Sílvia S. Guterres and Adriana R. Pohlmann (2012). Hemocompatibility of poly(ε-caprolactone) lipid-core nanocapsules stabilized with polysorbate 80-lecithin and uncoated or coated with chitosan. Int J Pharm, 426(1-2): 271– 279.
Esmaeili A, Rahnamoun S and Sharifnia F (2013). Effect of O/W process parameters on Crataegus azarolus L nanocapsule properties. J Nanobiotechnology, 11:16, doi: 10.1186/1477-3155-11-16.
Falqueiro AM, Primo FL, Morais PC, Mosiniewicz-Szablewska E, Suchocki P and Tedesco AC (2011). Selol-loaded magnetic nanocapsules: A new approach for hyperthermia cancer therapy. J Appl Phys, 109(7): 07B306, https://doi.org/10.1063/1.3556950.
Friedrich RB, Fontana MC, Ruy Carlos R. Beck, Pohlmann AR and Guterres SS (2008). Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions. Quim Nova, 31(5): 1131-1136.
Goethals EC (2013). Templated synthesis of polymer nanocapsules: The role of template characteristics in the efficiency of drug delivery systems. A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy (Applied Chemistry). School of Applied Sciences, RMIT University.
Hassou M, Couenne F, Le Gorrec Y and Tayakout M (2009). Modeling and simulation of polymeric nanocapsule formation by emulsion diffusion method. AIChE, 55(8): 2094-2105.
Hirsjärvi S, Qiao Y, Royere A, Bibette J and Benoit JP (2010). Layer-by-layer surface modification of lipid nanocapsules. Eur J Pharm Biopharm, 76(2): 200-207.
Hoffmeister CR, Durli TL, Schaffazick SR, Raffin RP, Bender EA, Beck RC, Pohlmann AR and Guterres SS (2012). Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery. Nanoscale Res Lett, 7(1):251, doi: 10.1186/1556-276X-7-251.
Huynh NT, Passirani C, Saulnier P and Benoit JP (2009). Lipid nanocapsules: A new platform for nanomedicine. Int J Pharm, 379(2): 201-209.
Kothamasu P, Kanumur H, Ravur N, Maddu C, Parasuramrajam R and Thangavel S (2012). Nanocapsules: The weapons for novel drug delivery systems. BioImpacts, 2(2): 71-81.
Mayer C (2005). Nanocapsules as drug delivery systems. Int J Artif Organs, 28(11): 1163-1171.
Meier W (2000). Polymer nanocapsules. Chem Soc Rev, 29: 295–303.
Moinard-Chécot D, Chevalier Y, Briançon S, Beney L and Fessi H (2008). Mechanism of nanocapsules formation by the emulsion–diffusion process. J Colloid Interface Sci, 317(2): 458-468.
Mona MA, Abdel-Mottaleb, Neumann D and Lamprecht A (2010). In vitro drug release mechanism from lipid nanocapsules (LNC). Int J Pharm, 390(2): 208-213.
Mora-Huertasa CE, Fessi H and Elaissari A (2010). Polymer-based nanocapsules for drug delivery. Int J Pharm, 385(1-2): 113-142.
Nagavarma BVN, Hemant KS Yadav, Ayaz A, Vasudha LS and Shivakumar HG (2012). Different techniques for preparation of polymeric nanoparticles- A review. Asian J Pharm Clin Res, 5(3): 16-23.
Nishiura H, Sugimoto K, Akiyama K, Musashi M, Kubota Y, Yokoyama T, Yamashita Y, Kuriki T and Yamaguchi Y (2013). A novel nano-capsule of α-lipoic acid as a template of core shell structure constructed by self-assembly. J Nanomed Nanotechnol, 4:155. doi:10.4172/2157-7439.1000155.
Paranjpe M and Müller-Goymann CC (2014). Nanoparticle-mediated pulmonary drug delivery: A review. Int J Mol Sci, 15(4): 5852-5873.
Pathak Y and Thassu D (2009). Drug Delivery Nanoparticles Formulation and Characterization. Informa Healthcare, New York, 29 and 30.
Prabhakar VK, Tapan, Yadav AB and Ratan R (2013). Magic bullets – nanocapsules in future medicine. Int J Pharm Sci, 3(4): 303-308.
Rawat M, Singh D, Saraf S and Saraf S (2006). Nanocarriers: Promising vehicle for bioactive drugs. Biol Pharm Bull, 29(9): 1790-1798.
Rube A (2007). Development and physico-chemical characterization of nanocapsules. Dissertation. Martin-Luther-University Halle/Wittenberg, Germany.
Sánchez-Moreno P, Ortega-Vinuesa JL, Martín-Rodríguez A, Boulaiz H, Marchal-Corrales JA and Peula-Garcí JM (2012). Characterization of different functionalized lipidic nanocapsules as potential drug carriers. Int J Mol Sci, 13(2): 2405-2424.
Schaffazick SR, Pohlmann AR, Graziela Mezzalira and Guterres SS (2006). Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin. J Braz Chem Soc, 17(3): 562-569.
Sharma J, Kalra S, Sharma A and Rani S (2009). Colloidal drug carriers. The Internet J Fam Pract, 9(2): 6 pages.
Sunitha A, Rimal Isaac RS, Sweetly Geo, Sornalekshmi S, Arsula Rose and Praseetha PK (2013). Evaluation of antimicrobial activity of biosynthesized iron and silver nanoparticles using the fungi Fusarium Oxysporum and Actinomycetes sp. on human pathogens. Nano Biomed Eng, 5(1): 39-45.
Thakur RS and Agrawal R (2015). Application of nanotechnology in pharmaceutical formulation design and development. Current Drug Therapy, 10(1): 20-34.
Thassu D, Deleers M and Pathak Y (2007). Nanoparticulate Drug Delivery Systems. 1st ed, Informa healthcare, New York.
Tiyaboonchai W (2003). Chitosan nanoparticles: A promising system for drug delivery. Naresuan University Journal, 11(3): 51-66.
Tomar A and Garg G (2013). Short review on application of gold nanoparticles. Global J Pharmacology, 7(1): 34-38.
Torchilin VP (2006). Nanoparticulates Drug Carriers. Imperial College Press, London. 263.
Varshosaz J, Hajhashemi V and Soltanzadeh S (2011). Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine. J Drug Delivery, 7 pages, https://doi.org/10.1155/ 2011/571272.
Vorgelegt der (2006). Development and physico-chemical characterization of nanocapsules. Dissertation. http://sundoc.bibliothek.uni-halle.de/diss-online/06/06H083/t1.pdf
Vrignaud S, Benoit JP and Saulnier P (2011). Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles. Biomaterials, 32(33): 8593-8604.
Zahid Hosen SM, Raju Dash, Md. Junaid and Umma Hane Khanam (2015). Pharmaceutical nanotechnology- A short review. DOI: 10.13140/RG.2.1.1432.7523.
Zhao YQ, Wang LP, Ma C, Zhao K, Liu Y and Feng NP (2013). Preparation and characterization of tetrandrine-phospholipid complex loaded lipid nanocapsules as potential oral carriers. Int J Nanomed, 8: 4169-4181.
Zhaparova L (2012). Synthesis of nanoparticles and nanocapsules for controlled release of the antitumor drug “Arglabin” and antituberculosis drugs. Dissertation. Eindhoven: Technische Universiteit Eindhoven DOI: 10.6100/IR731636.
Ai H and Gao J (2004). Size-controlled polyelectrolyte nanocapsules via layer-by-layer self-assembly. J Mat Sci, 39: 1429-1432.
Anton N, Saulnier P, Gaillard C, Porcher E, Vrignaud S and Benoit JP (2009). Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules. Langmuir, 25(19): 11413-11419.
Ashwini Kumar G, Amit Bhat and Shoba Rani (2010). Preparation and characterization of diltiazem nanocapsules: Influence of various polymers. Asian J Pharm, 4(3): 224-234.
Bhardwaj A, Lalit Kumar and Veenu K (2011). Colloidal drug delivery systems: A future prospective for treatment of tuberculosis. American J PharmTech Res, 1(3): 102-123.
Bhatia S (2016). Natural Polymer Drug Delivery Systems. Chapter 2 Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications. Springer International Publishing, Switzerland, 34.
Blaiszik BJ, Sottos NR and White SR (2008). Nanocapsules for self-healing materials. Comp Sci Tech, 68(3-4): 978-986.
Bolhassani A, Javanzad S, Saleh T, Mehrdad Hashemi, Mohammad Reza Aghasadeghi and Seyed Mehdi Sadat (2014). Polymeric nanoparticles. Hum Vaccin Immunother, 10(2): 321-332.
Carbone C, Musumeci T, Lauro MR and Puglisia G (2015). Eco-friendly aqueous core surface-modified nanocapsules. Colloids Surf B Biointerfaces, 125: 190-196.
Cauchetier E, Deniau M, Fessi H, Astier A and Paul M (2003). Atovaquone-loaded nanocapsules: Influence of the nature of the polymer on their in vitro characteristics. Int J Pharm, 250(1): 273-281.
Couvreur P, Barratt G, Fattal E, Legrand P and Vauthier C (2002). Nanocapsule technology: A review. Crit Rev Ther Drug Carrier Syst, 19(2): 99-134.
D’Souza S (2014). A Review of in vitro drug release test methods for nano-sized dosage forms. Advances in Pharmaceutics, pp-1-12. https://doi.org/10.1155/2014/304757.
De Melo NF, Grillo R, Guilherme VA, De Araujo DR, De Paula E, Rosa AH and Fraceto LF (2011). Poly (Lactide-co-Glycolide) Nanocapsules containing benzocaine: Influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity. Pharm Res, 28(8): 1984-1994.
Dineshkumar B, Krishnakumar K, Anish John, David Paul, Joseph Cherian and Panayappan L (2013). Nanocapsules: A novel nano-drug delivery system. Int J Res Drug Delivery, 3(1): 1-3.
Eduardo A. Bender, Márcia D. Adorne, Letícia M. Colomé, Dulcinéia S.P. Abdalla, Sílvia S. Guterres and Adriana R. Pohlmann (2012). Hemocompatibility of poly(ε-caprolactone) lipid-core nanocapsules stabilized with polysorbate 80-lecithin and uncoated or coated with chitosan. Int J Pharm, 426(1-2): 271– 279.
Esmaeili A, Rahnamoun S and Sharifnia F (2013). Effect of O/W process parameters on Crataegus azarolus L nanocapsule properties. J Nanobiotechnology, 11:16, doi: 10.1186/1477-3155-11-16.
Falqueiro AM, Primo FL, Morais PC, Mosiniewicz-Szablewska E, Suchocki P and Tedesco AC (2011). Selol-loaded magnetic nanocapsules: A new approach for hyperthermia cancer therapy. J Appl Phys, 109(7): 07B306, https://doi.org/10.1063/1.3556950.
Friedrich RB, Fontana MC, Ruy Carlos R. Beck, Pohlmann AR and Guterres SS (2008). Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions. Quim Nova, 31(5): 1131-1136.
Goethals EC (2013). Templated synthesis of polymer nanocapsules: The role of template characteristics in the efficiency of drug delivery systems. A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy (Applied Chemistry). School of Applied Sciences, RMIT University.
Hassou M, Couenne F, Le Gorrec Y and Tayakout M (2009). Modeling and simulation of polymeric nanocapsule formation by emulsion diffusion method. AIChE, 55(8): 2094-2105.
Hirsjärvi S, Qiao Y, Royere A, Bibette J and Benoit JP (2010). Layer-by-layer surface modification of lipid nanocapsules. Eur J Pharm Biopharm, 76(2): 200-207.
Hoffmeister CR, Durli TL, Schaffazick SR, Raffin RP, Bender EA, Beck RC, Pohlmann AR and Guterres SS (2012). Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery. Nanoscale Res Lett, 7(1):251, doi: 10.1186/1556-276X-7-251.
Huynh NT, Passirani C, Saulnier P and Benoit JP (2009). Lipid nanocapsules: A new platform for nanomedicine. Int J Pharm, 379(2): 201-209.
Kothamasu P, Kanumur H, Ravur N, Maddu C, Parasuramrajam R and Thangavel S (2012). Nanocapsules: The weapons for novel drug delivery systems. BioImpacts, 2(2): 71-81.
Mayer C (2005). Nanocapsules as drug delivery systems. Int J Artif Organs, 28(11): 1163-1171.
Meier W (2000). Polymer nanocapsules. Chem Soc Rev, 29: 295–303.
Moinard-Chécot D, Chevalier Y, Briançon S, Beney L and Fessi H (2008). Mechanism of nanocapsules formation by the emulsion–diffusion process. J Colloid Interface Sci, 317(2): 458-468.
Mona MA, Abdel-Mottaleb, Neumann D and Lamprecht A (2010). In vitro drug release mechanism from lipid nanocapsules (LNC). Int J Pharm, 390(2): 208-213.
Mora-Huertasa CE, Fessi H and Elaissari A (2010). Polymer-based nanocapsules for drug delivery. Int J Pharm, 385(1-2): 113-142.
Nagavarma BVN, Hemant KS Yadav, Ayaz A, Vasudha LS and Shivakumar HG (2012). Different techniques for preparation of polymeric nanoparticles- A review. Asian J Pharm Clin Res, 5(3): 16-23.
Nishiura H, Sugimoto K, Akiyama K, Musashi M, Kubota Y, Yokoyama T, Yamashita Y, Kuriki T and Yamaguchi Y (2013). A novel nano-capsule of α-lipoic acid as a template of core shell structure constructed by self-assembly. J Nanomed Nanotechnol, 4:155. doi:10.4172/2157-7439.1000155.
Paranjpe M and Müller-Goymann CC (2014). Nanoparticle-mediated pulmonary drug delivery: A review. Int J Mol Sci, 15(4): 5852-5873.
Pathak Y and Thassu D (2009). Drug Delivery Nanoparticles Formulation and Characterization. Informa Healthcare, New York, 29 and 30.
Prabhakar VK, Tapan, Yadav AB and Ratan R (2013). Magic bullets – nanocapsules in future medicine. Int J Pharm Sci, 3(4): 303-308.
Rawat M, Singh D, Saraf S and Saraf S (2006). Nanocarriers: Promising vehicle for bioactive drugs. Biol Pharm Bull, 29(9): 1790-1798.
Rube A (2007). Development and physico-chemical characterization of nanocapsules. Dissertation. Martin-Luther-University Halle/Wittenberg, Germany.
Sánchez-Moreno P, Ortega-Vinuesa JL, Martín-Rodríguez A, Boulaiz H, Marchal-Corrales JA and Peula-Garcí JM (2012). Characterization of different functionalized lipidic nanocapsules as potential drug carriers. Int J Mol Sci, 13(2): 2405-2424.
Schaffazick SR, Pohlmann AR, Graziela Mezzalira and Guterres SS (2006). Development of nanocapsule suspensions and nanocapsule spray-dried powders containing melatonin. J Braz Chem Soc, 17(3): 562-569.
Sharma J, Kalra S, Sharma A and Rani S (2009). Colloidal drug carriers. The Internet J Fam Pract, 9(2): 6 pages.
Sunitha A, Rimal Isaac RS, Sweetly Geo, Sornalekshmi S, Arsula Rose and Praseetha PK (2013). Evaluation of antimicrobial activity of biosynthesized iron and silver nanoparticles using the fungi Fusarium Oxysporum and Actinomycetes sp. on human pathogens. Nano Biomed Eng, 5(1): 39-45.
Thakur RS and Agrawal R (2015). Application of nanotechnology in pharmaceutical formulation design and development. Current Drug Therapy, 10(1): 20-34.
Thassu D, Deleers M and Pathak Y (2007). Nanoparticulate Drug Delivery Systems. 1st ed, Informa healthcare, New York.
Tiyaboonchai W (2003). Chitosan nanoparticles: A promising system for drug delivery. Naresuan University Journal, 11(3): 51-66.
Tomar A and Garg G (2013). Short review on application of gold nanoparticles. Global J Pharmacology, 7(1): 34-38.
Torchilin VP (2006). Nanoparticulates Drug Carriers. Imperial College Press, London. 263.
Varshosaz J, Hajhashemi V and Soltanzadeh S (2011). Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine. J Drug Delivery, 7 pages, https://doi.org/10.1155/ 2011/571272.
Vorgelegt der (2006). Development and physico-chemical characterization of nanocapsules. Dissertation. http://sundoc.bibliothek.uni-halle.de/diss-online/06/06H083/t1.pdf
Vrignaud S, Benoit JP and Saulnier P (2011). Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles. Biomaterials, 32(33): 8593-8604.
Zahid Hosen SM, Raju Dash, Md. Junaid and Umma Hane Khanam (2015). Pharmaceutical nanotechnology- A short review. DOI: 10.13140/RG.2.1.1432.7523.
Zhao YQ, Wang LP, Ma C, Zhao K, Liu Y and Feng NP (2013). Preparation and characterization of tetrandrine-phospholipid complex loaded lipid nanocapsules as potential oral carriers. Int J Nanomed, 8: 4169-4181.
Zhaparova L (2012). Synthesis of nanoparticles and nanocapsules for controlled release of the antitumor drug “Arglabin” and antituberculosis drugs. Dissertation. Eindhoven: Technische Universiteit Eindhoven DOI: 10.6100/IR731636.
