Terpenoids from Dicliptera chinensis (L.) Nees Grown in Vietnam and their Anti-inflammatory Activities

DOI:

https://doi.org/10.37285/ijpsn.2018.11.2.7

Authors

  • Loi Vu Duc
  • Tung Bui Thanh
  • Tung Nguyen Huu

Abstract

The main goal of this study was to isolate and screen the therapeutic potential of some terpenoids from Dicliptera chinensis (L.) Nees grown in Vietnam. From the leaves of Dicliptera chinensis (L.) Nees (Acanthaceae) collected in Nam Dinh province, one new terpenoid (1) together with five known (2-6) were isolated by chromatographic methods. These compounds were identified as 6-hydroxy-1,12-oleanadien-3-on (1), 1β,4β-dihydroxyeudesm-11-ene (2), 3β-hydroxylup-20(29)-en (3), stigmast-5,22-dien-3-β-ol (4), rutaevine (5), mangiferin (6). All of them were isolated from this plant for the first time. Compound 4 showed signficant potential for COX-2 inhibitory effects with IC50 values of 7.32± 1.82 µg/mL. These pilot results suggest the potential of Dicliptera terpenoids for treating inflamatory conditions. 

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Keywords:

Dicliptera chinensis, 1β,4β-dihydroxyeudesm-11-ene, 3β-hydroxylup-20 (29)-20(29)-en, Stigmast-5,22-dien-3-β-ol, rutaevine, mangiferin

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Published

2018-03-31

How to Cite

1.
Duc LV, Thanh TB, Huu TN. Terpenoids from Dicliptera chinensis (L.) Nees Grown in Vietnam and their Anti-inflammatory Activities. Scopus Indexed [Internet]. 2018 Mar. 31 [cited 2024 Apr. 20];11(2):4052-6. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/363

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References

Abdullahi S, A. Musa, M. Abdullahi, M. Sule and Y. Sani (2013). Isolation of Lupeol from the Stem-bark of Lonchocarpus sericeus (Papilionaceae). Scholars Academic Journal of Biosciences 1(1): 18-19.
Ballesta-Acosta MC, M. J. Pascual-Villalobos and B. Rodríguez (2002). A new 24-nor-oleanane triterpenoid from Salvia carduacea. Journal of Natural Products 65(10): 1513-1515.
Botting R (2006). Inhibitors of Cyclooxygenases: mechanisms, Selectivity and Uses. Journal of Physiology and Pharmacology 57: 113.
Chen S (2011). Natural products triggering biological targets-a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis. Current Drug Targets 12(3): 288-301.
Gao Y-T., X.-W. Yang and T.-M. Ai (2007). Chemical constituents of whole herb of Dicliptera chinensis. Chinese Traditional and Herbal Drugs 38(1): 14.
Kutil, Z., M. Kvasnicova, V. Temml, D. Schuster, P. Marsik, E. F. Cusimamani, J.-D. Lou, T. Vanek and P. Landa (2015). Effect of dietary stilbenes on 5-lipoxygenase and cyclooxygenases activities in vitro. International Journal of Food Properties 18(7): 1471-1477.
Lee JL, H. Mukhtar, D. R. Bickers, L. Kopelovich and M. Athar (2003). Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicology and Applied Pharmacology 192(3): 294-306.
Li X, M. Yang, Y.-F. Han and K. Gao (2005). New sesquiterpenes from Erigeron annus. Planta Medica 71(03): 268-272.
Lin CC, M. L. Lin and J. M. Lin (1993). The antiinflammatory and liver protective effect of Tithonia diversifolia (Hemsl.) gray and Dicliptera chinensis Juss. Extracts in rats. Phytotherapy Research 7(4): 305-309.
Mujeeb F, P. Bajpai and N. Pathak (2014). Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos. Bio Med Res International 2014.
Mukherjee, D., S. E. Nissen and E. J. Topol (2001). Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA 286(8): 954-959.
Núñez, M. J., M. L. Kennedy, I. A. Jiménez and I. L. Bazzocchi (2011). Uragogin and blepharodin, unprecedented hetero-Diels–Alder adducts from Celastraceae species. Tetrahedron 67(17): 3030-3033.
Sahu, B. P., P. Goud and C. Patnaik (2016). Pandanus Odaritissimus Linn: Isolation of Stigmast-5, 22-dien-3β-ol from Ethanolic Extract of Stem Bark and Study of Antimicrobial Activity. Journal of Chemistry and Chemical Sciences 6(6): 574-585.
Salomon, S., I. Sevilla, R. Betancourt, A. Romero, L. Nuevas-Paz and J. Acosta-Esquijarosa (2014). Extraction of mangiferin from Mangifera indica L. leaves using microwave-assisted technique. Emirates Journal of Food and Agriculture 26(7): 616.
Shinde, S. and A. Chavan (2014). Isolation of mangiferin from different varieties of Mangifera indica dried leaves. IJSER 5: 928-934.
Vane, J. (1994). Towards a better aspirin. Nature 367(6460): 215.
Wal, A., P. Wal, A. Rai and R. Kanwal (2010). Isolation and modification of pseudohybrid plant (Lupeol). J Pharm Sci Res 2: 13-25.
Wu, Y.-B., Z.-Y. Ni, Q.-W. Shi, M. Dong, H. Kiyota, Y.-C. Gu and B. Cong (2012). Constituents from Salvia species and their biological activities. Chemical Reviews 112(11): 5967-6026.
Zhang K, H. Zhu and Y. Gao (2010). Research on active extracts of Dicliptera chinensis on liver protection. J Chinese Materia Medica 35(4): 497-498.