Nanoemulsion: Composition, Preparation and its Application in the Food Industry

DOI:

https://doi.org/10.37285/ijpsn.2024.17.3.9

Authors

  • Pragati Singh Department of Home Science, Banasthali Vidyapith, Tonk,
  • Somya Khanna Department of Home Science, Banasthali Vidyapith, Tonk,
  • Ekta Singh Chauhan Department of Home Science, Banasthali Vidyapith, Tonk,

Abstract

Nanotechnology deals with the application of atoms, molecules, or macromolecules with sizes ranging from 1 to 100 nm to create and utilize materials with distinct and novel characteristics. Nanotechnology has gained popularity over the past few decades and is now widely regarded as a revolutionary technology in the food industry. Various nanoencapsulation techniques have been spawned by the boom in interest in nanotechnology and its application in food products. One of the most exciting encapsulating and delivering methods in the food sector is nanoemulsion. 

A nanoemulsion is a mixture of two immiscible liquids and a surfactant that takes the form of tiny droplets less than 200 nm in size. Delivery methods based on nanoemulsions increase the bioavailability of the bioactive substances that are encapsulated and improve food stability. Since nanoemulsions are thermodynamically unstable, they need a certain amount of energy to create them. The preparation technique chosen determines the creation and permanence of nanoemulsions.

This review provides an overview of nanoemulsion terminology and formulation; and also addresses various approaches for producing nanoemulsions, including both high- and low-energy techniques. In addition, the applications of nanoemulsions in the food industry.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

nanotechnology, emulsion, nanoemulsion, bioactives encapsulation, nutrient delivery system

Published

2024-06-30

How to Cite

1.
Singh P, Khanna S, Chauhan ES. Nanoemulsion: Composition, Preparation and its Application in the Food Industry. Scopus Indexed [Internet]. 2024 Jun. 30 [cited 2024 Jul. 6];17(3):7398-405. Available from: http://ijpsnonline.com/index.php/ijpsn/article/view/3769

Issue

Section

Review Articles

References

Singh T, Shukla S, Kumar P, Wahla V, Bajpai VK, Rather IA. Application of Nanotechnology in Food Science: Perception and Overview. Frontiers in Microbiology. 2017;8:1501.

Yu H, Park JY, Kwon CW, Hong SC, Park KM, Chang PS. An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety. Journal of Chemistry. 2018;2018:1–10.

Zhao Q, Wu C, Yu C, Bi A, Xu X, Du M. High Stability of Bilayer Nano-emulsions Fabricated by Tween 20 and Specific Interfacial Peptides. Food Chemistry. 2020;340:127877.

Guttoff M, Saberi AH, McClements DJ. Formation of Vitamin D Nanoemulsion-Based Delivery Systems by Spontaneous Emulsification: Factors Affecting Particle Size and Stability. Food Chemistry. 2015;171:117–122.

McClements DJ. Edible Nanoemulsions: Fabrication, Properties, and Functional Performance. Soft Matter. 2011;7:2297–2316.

Castro-Criado D, Jiménez-Rosado M, Perez-Puyana V, Romero A. Soy Protein Isolate as Emulsifier of Nanoemulsified Beverages: Rheological and Physical Evaluation. Foods. 2023;12:507.

Rashidi L, Khosravi-Darani K. The Applications of Nanotechnology in Food Industry. Critical Reviews in Food Science and Nutrition. 2011;51(8):723–730.

Panigrahi SS, Syed I, Sivabalan S, Sarkar P. Nanoencapsulation Strategies for Lipid-Soluble Vitamins. Chemical Papers. 2019;73:1-16.

Aswathanarayan JB, Vittal RR. Nanoemulsions and Their Potential Applications in Food Industry. Frontiers in Sustainable Food Systems. 2019;3:1-21.

Zhang R, Zhang Z, McClements DJ. Nanoemulsions: An Emerging Platform for Increasing the Efficacy of Nutraceuticals in Foods. Colloids Surf. B Biointerfaces. 2020;194:111202.

Kumar DHL, Sarkar P. Encapsulation of Bioactive Compounds Using Nanoemulsions. Environ Chem Lett. 2018;16:59–70.

Salem MA, Ezzat SM. Nanoemulsions in Food Industry. In Some New Aspects Colloid Syst Foods. 2018 (pp. 238–267). IntechOpen.

Jafari SM, McClements DJ. Nanotechnology Approaches for Increasing Nutrient Bioavailability. Adv. Food Nutr. Res. 2017;81:1–30.

Li M, McClements DJ, Liu X, Liu F. Design Principles of Oil-in-Water Emulsions with Functionalized Interfaces: Mixed, Multilayer, and Covalent Complex Structures. Compr. Rev. Food Sci. Food Saf. 2020;19:3159–3190.

Noori S, Zeynali F, Almasi H. Antimicrobial and Antioxidant Efficiency of Nanoemulsion-Based Edible Coating Containing Ginger (Zingiber Officinale) Essential Oil and Its Effect on Safety and Quality Attributes of Chicken Breast Fillets. Food Control. 2018;84:312–320.

Dammak I, Sobral PJdA, Aquino A, Neves MAD, Conte-Junior CA. Nanoemulsions: Using Emulsifiers from Natural Sources Replacing Synthetic Ones- A review. Comprehensive Reviews in Food Science and Food Safety. 2020;19:1541-4337.

AS AU, Kumar P, Ranganathan TV. Emulsion and it’s Applications in Food Industry- A Review. Int. Journal of Engineering Research and Applications. 2014;4(4):241-248.

Kale S, Deore S. Emulsion Micro Emulsion and Nano Emulsion: A Review. Systematic Reviews in Pharmacy. 2016;(8):39-47.

McClements DJ. Food Emulsions: Principles, Practices, and Techniques. 2015:3. CRC Press: Boca Raton, FL, USA.

Tan C, McClements DJ. Application of Advanced Emulsion Technology in the Food Industry: A Review and Critical Evaluation. Foods. 2021;10(4):812.

Mitsou E, Tavantzis G, Sotiroudis GT, Ladikos D, Xenakis A, Papadimitriou V. Food Grade Water-in-Oil Microemulsions as Replacement of Oil Phase to Help Process and Stabilization of Whipped Cream. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2016;510:69-76.

Madaan V, Chanana A, Kataria, M. K.; Bilandi, A. Emulsion Technology and Recent Trends in Emulsion Applications. International Research Journal of Pharmacy. 2014;5(7):533–542.

Akbari S, Nour AH. Emulsion Types, Stability Mechanisms and Rheology: A Review. International Journal of Innovative Research and Scientific Studies. 2018;1:14-21.

Divya K, Divyasree R, Vamsidhar M, Bhavani K, Bhanja S, Sudhakar M, Panda D, Panigrahi B. Emulsion, Micro Emulsion and Nano Emulsion: A Review. World Journal of Pharmacy and Pharmaceutical Sciences. 2021;10:641-660.

Barkat A, Khan, B, Naveed A, Muhammad, H, Khan H, Mohhamad S, Waseem K, Mahmood T, Rasul A, Iqbal M, Khan H. Basics of Pharmaceutical Emulsions: A Review. African Journal of Pharmacy and Pharmacology. 2011;525:2715-2725.

Goodarzi F, Zendehboudi S. A Comprehensive Review on Emulsions and Emulsion Stability in Chemical and Energy Industries. The Canadian Journal of Chemical Engineering. 2019;97(1):281–309.

Singh V, Kataria MK, Bilandi A. Recent Advances in Pharmaceutical Emulsion Technology. Journal of Pharmacy Research. 2012;5(8):4250-4258.

O’Sullivan JJ, Drapala KP, Kelly AL, O’Mahony JA. The Use of Inline High-Shear Rotor-Stator Mixing for Preparation of High Solids Milk Protein-Stabilised Oil-in-Water Emulsions with Different Protein: Fat Ratios. J Food Eng. 2018;222:218–225.

Colucci G, Santamaria-Echart A, Silva SC, Fernandes IPM, Sipoli CC, Barreiro MF. Development of Water-in-Oil Emulsions as Delivery Vehicles and Testing with a Natural Antimicrobial Extract. Molecules. 2020;25(9):1-15.

Naseema A, Kovooru L, Behera AK, Kumar KP, Srivastava PA. Critical Review of Synthesis Procedures, Applications and Future Potential of Nanoemulsions. Adv Colloid Interface Sci. 2020;102318.

Mohammadi A, Jafari SM, Esfanjani AF, Akhavan S. Application of Nano-Encapsulated Olive Leaf Extract in Controlling the Oxidative Stability of Soybean Oil. Food Chem. 2016;190:513–519.

Sheth T, Seshadri S, Prileszky T, Helgeson ME. Multiple nanoemulsions. Nat. Rev. Mater. 2020;5:214−228.

Hema SK, Karmakar A, Das RK, Srivastava P. Simple Formulation and Characterization of Double Emulsion Variant Designed to Carry Three Bioactive Agents. Heliyon. 2022;8(9):10397.

Garti N, Aserin A. Double emulsions stabilized by macromolecular surfactants. In Micelles, microemulsions, and monolayers. 2018 (pp. 333–362). Routledge.

Serdaroglu M, Öztürk KB. An Overview of Food Emulsions: Description, Classification and Recent Potential Applications. Turkish Journal of Agriculture-Food Science and Technology. 2015;3(6):430-438.

Komaiko JS, McClements DJ. Formation of Food-Grade Nanoemulsions Using Low-Energy Preparation Methods: A Review of Available Methods. Comprehens. Rev. Food Sci. Safety. 2016;15:331–352.

Saxena C, Chaurasia L, Arora K. A Review on Comparative Study Between Emulsion, Microemulsion and Nanoemulsion. International Journal of Research in Pharmaceutical and Nano Sciences. 2018;7(4):149 - 156.

AL-Bukhaiti WQ, Noman A, Ali A, Abed S, Wang H. Emulsions: Micro and Nano-emulsions and their Applications in Industries – A Mini–Review. International Journal of Agriculture Innovations and Research. 2018;7(1):55-63.

Mcclements DJ. Nanoemulsions Versus Microemulsions: Terminology, Differences, and Similarities. Soft Matter. 2012;8:1719-1729.

Anton N, Vandamme TF. Nano-emulsions and Micro-emulsions: Clarifications of the Critical Differences. Pharm Res. 2011;28(5):978–985.

Koh KS, Wong VL. Introductory Chapter: From Microemulsions to Nanoemulsions. In Nanoemulsions - Properties, Fabrications and Applications. 2019. IntechOpen.

Bai L, Huan S, Rojas OJ, McClements DJ. Recent Innovations in Emulsion Science and Technology for Food Applications. Journal of Agricultural and Food Chemistry. 2021;69:8944-8963.

Chircov C, Grumezescu AM. Nanoemulsion Preparation, Characterization, and Application in the Field of Biomedicine. In Nanoarchitectonics in Biomedicine. 2019 (pp. 169–188). William Andrew: Applied Science Publishers, United States.

Ali A, Ansari VA, Usama U, Akhtar J, Jahan A. Nanoemulsion: An Advanced Vehicle for Efficient Drug Delivery. Drug Research. 2017;67:617-631.

Banasaz S, Morozova K, Ferrentino G, Scampicchio M. Encapsulation of Lipid-Soluble Bioactives by Nanoemulsions. Molecules. 2020;25(17):3966.

Mahajan HS, Savale SK. Nanoemulsions: A Versatile Mode of Drug Delivery System. Indian Journal of Novel Drug Delivery. 2016;8(3):123-132.

Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: An Advanced Mode of Drug Delivery System. 3 Biotech. 2015;5:123–127.

Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Vieira GS, Oliveira GO Rocha-filho PA. Formation and Stability of Oil-in-Water Nanoemulsions Containing Rice Bran Oil: In Vitro and in Vivo Assessments. Journal of Nanobiotechnology 2011;9:1-9.

Troncoso E, Aguilera JM, McClements DJ. Fabrication, Characterization and Lipase Digestibility of Food-Grade Nanoemulsions. Food Hydrocolloid. 2012;27(2):355-363.

Nethaji DK, Parambil KA. Development and Applications of Nano Emulsion in Food Technology. International Journal of Science, Engineering and Management. 2017;4(2):46-49.

Borthakur P, Boruah PK, Sharma B, Das MR. Nanoemulsion: Preparation and its Application in Food Industry. Emulsions. 2016;3:153-191.

Bai L, McClements DJ. Formation and stabilization of nanoemulsions using biosurfactants: Rhamnolipids. Journal of Colloid and Interface Science. 2016;479:71-79.

Hossam HY, Raed F, Sarah A, Nojod H. Nanoemulsions: Formulation, Characterization, Biological Fate, and Potential Role Against COVID-19 and Other Viral Outbreaks. Colloid and Interface Science Communications. 2021;45:100533.

Liu Q, Huang H, Chen H, Lin J, Wang Q. Food-Grade Nanoemulsions: Preparation, Stability and Application in Encapsulation of Bioactive Compounds. Molecules. 2019;24(23):4242.

Marzuki NHC, Wahab RA, Hamid AM. An Overview of Nanoemulsion: Concepts of Development and Cosmeceutical Applications. Biotechnology & Biotechnological Equipment. 2019;33(1):779–797.

Shah P, Bhalodia D, Shelat P. Nanoemulsion: A Pharmaceutical Review. Sys. Rev. Pharm. 2010;1:24–32.

Chime SA, Kenechukwu FC, Attama AA. Nanoemulsions- Advances in Formulation, Characterization and Applications in Drug Delivery. In Application of nanotechnology in drug delivery. 2014 (pp 77-126). IntechOpen.

Santana RC, Perrechil FA, Cunha RL. High-and Low-Energy Emulsifications for Food Applications: A Focus on Process Parameters. Food Eng Rev. 2013;5(2):107–122.

Galvão KCS, Vicente AA, Sobral PJA. Development, Characterization, and Stability of O/W Pepper Nanoemulsions Produced by High-Pressure Homogenization. Food and Bioprocess Technology. 2018;11(2):355–367.

Salvia-Trujillo L, Soliva-Fortuny R, Rojas-Grau MA, McClements DJ, Martin-Belloso O. Edible Nanoemulsions as Carriers of Active Ingredients: A Review. Annu. Rev. Food Sci. Technol. 2017;8:439–466.

Saffarionpour S. Preparation of Food Flavor Nanoemulsions by High- and Low-Energy Emulsification Approaches. Food Eng. Rev. 2019;11(4):259–289.

Malode GP, Chavhan SA, Bartare SA, Malode LL, Manwar JV, Bakal RLA, Critical Review on Nanoemulsion: Advantages, Techniques and Characterization. Journal of Applied Pharmaceutical Sciences and Research. 2021;4(3):6-12.

Liu J, Bi J, Liu X, Zhang B, Wu X, Wellala CKD, Zhang B. Effects of High Pressure Homogenization and Addition of Oil on the Carotenoid Bioaccessibility of Carrot Juice. Food Function. 2019;10:458–468.

Hadžiabdić J, Džana O, Elezovic A, Vranic E, Rahic O. Preparation of Nanoemulsions by High-energy and Low-energy Emulsification Methods. In Cmbebih 2017, 2017 (pp. 317–322). Springer.

Cerpnjak K, Zvonar A, Gašperlin M, Vrečer F. Lipid-Based Systems as a Promising Approach for Enhancing the Bioavailability of Poorly Water-Soluble Drugs. Acta Pharm. 2013;63(4):427-445.

Ganta S, Talekar M, Singh A, Coleman TP, Amiji MM. Nanoemulsions in Translational Research-Opportunities and Challenges in Targeted Cancer Therapy. AAPS Pharm Sci Tech. 2014;15(3):694-708.

Shams N, Sahari MA. Nanoemulsions: Preparation, Structure, Functional Properties and Their Antimicrobial Effects. Appl. Food Biotechnol. 2016;3:138–149.

Jafari SM, McClements DJ. Nanoemulsions: Formulation, Applications, and Characterization, 2018, Elsevier Inc.: India.

Dammak I, Sobral PJdA. Formulation and Stability Characterization of Rutin-Loaded Oil-in-Water Emulsions. Food and Bioprocess Technology. 2017;10(5):926–939.

Gupta A, Eral HB, Hatton TA, Doyle PS. Nanoemulsions: Formation, Properties and Applications. Soft Matter. 2016;12(11):2826–2841.

Sarheed O, Shouqair D, Ramesh KVRNS, Khaleel T, Amin M, Boateng J, Drechsler M. Formation of Stable Nanoemulsions by Ultrasound-Assisted Two-Step Emulsification Process for Topical Drug Delivery: Effect of Oil Phase Composition and Surfactant Concentration and Loratadine as Ripening Inhibitor. Int J Pharm. 2020;576:118952.

Islam F, Saeed F, Afzaal M, Hussain M, Ikram A, Khalid MA. Food Grade Nanoemulsions: Promising Delivery Systems for Functional Ingredients. Journal of Food Science and Technology. 2022;60:1461-1471.

Silva HD, Cerqueira MA, Vicente AA. Nanoemulsions for Food Applications: Development and Characterization. Food and Bioprocess Technology. 2012;5(3):854-867.

Yukuyama MN, Ghisleni DD, Pinto TJ, Bou-Chacra NA. Nanoemulsion: Process Selection and Application in Cosmetics - A Review. Int J Cosmet Sci. 2016;38(1):13-24.