A Profile of the Biological Activity of Functionalized Benzimidazolium Ionic Liquids
DOI:
https://doi.org/10.37285/ijpsn.2020.13.5.9Abstract
Now-a-days, the pharmaceutical industries were facing many challenges that impose the need to develop innovative and effective therapies. Hence, the investigation of effective therapies for cancer is an actual goal of every pharmaceutical industries. Recently, Ionic Liquids (ILs) have been considered as potential target in scientific community because of their unique performance in various fields. Moreover, numerous combinations made between the cation and the anion, which can be tuned the physicochemical and biological properties of ILs. Especially, these ionic liquids play a vital role for designing new drugs and producing potent bioactivity. Herein we synthesized a series of benzimidazolium based ionic liquids with different functional groups and their structure was confirmed by FT-IR, 1H NMR, 13C NMR as well as High resolution Mass spectroscopy technique antimicrobial activity of ILs were screened by five bacterial and fungal strains which was measured in terms of zone of inhibition. All the compounds were found to be effective against all bacterial species and fungi Candida albicans. Moreover, the total antioxidant capacity of ILs has been evaluated by Phosphomolybdenum method. The report indicates that kojic acid functionalized ILs exhibited significant antioxidant activity. In addition, antitumor activity of these compounds has been analyzed using human ovarian cancer cell line SK-OV-3, human prostate cancer cell line DU-145 and human leukemia cancer cell line K-562. The data obtained from antitumour studies showed that an excellent activity of ester functionalized ionic liquid confirms that can be used as an anticancer agent. However, ester functionalized and kojic acid functionalized ILs possess biologically active against the tested strains
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Benzimidazolium based ionic liquids, Antimicrobial activity, Total antioxidant capacity, Antitumor activity, Kojic acid functionalized ionic liquids
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