Recent Advances in Nanogels in Drug Delivery Systems
DOI:
https://doi.org/10.37285/ijpsn.2021.14.1.3Abstract
Over the last decades, the development of nanotechnology has caused great advances and growth in the field of nanoparticle-based medical sciences, especially in the area of drug delivery. These novel nano based systems can either be therapeutic agents themselves, or else act as vehicles to carry different active pharmaceutical agents into specific parts of the body. Keeping the point in thoughts it is believed that the tagging of presently used therapeutic compounds to nanocarriers will likely lead to improved approaches for enlightening the drug activity of these therapeutic compounds and suggestively improves our aptitude to treat numerous human diseases and would be an aid to tissue regeneration, wound healing, and surgical devices. Here in this report we are specifically taking Nanogel into consideration, Nanogels are one of the techniques in nanotechnology which has been most prevalent in successful medication delivery inside the body and in addition topical treatment, nanogel and hydrogel formulations have shown promising advantages for topical and trans-mucosal routes of administration. The nanoparticle drug within the gel matrix showed significant enhancement in the permeation of drugs in the topical and transdermal drug delivery. The quest of this review article is to understand why nanogel is a revolutionary drug delivery system, methods to prepare them, applications in biomedical and pharmaceutical discipline, mechanism of drug release from nanogel carrier, features and advantages of nanogels, the main characteristics, such as: swelling capacity, stimuli sensitivity, the great surface area, functionalization, bioconjugation and encapsulation of bioactive substances, which are taken into account in designing the structures according to the application; some data on the advantages and limitations of the formulation also investigate different approved nano formulations currently on the market, and briefly cover the challenges and future outlook as Nano carrier systems.
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Nanogel, drug release, cross linking, stability release mechanism
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