Raft Forming Systems: A Novel Approach to Gastric Retention

DOI:

https://doi.org/10.37285/ijpsn.2021.14.5.3

Authors

  • Sai Mahesh G Department of Pharmaceutics, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, Bhimavaram-534 202, W.G. Dist., A.P., India.
  • Suraj Narayana M Department of Pharmaceutics, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, Bhimavaram-534 202, W.G. Dist., A.P., India.
  • Glory Margaret P Department of Pharmaceutics, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, Bhimavaram-534 202, W.G. Dist., A.P., India.
  • Mohan Varma M Department of Pharmaceutics, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, Bhimavaram-534 202, W.G. Dist., A.P., India.
  • P. V Swamy Department of Pharmaceutics, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, Bhimavaram-534 202, W.G. Dist., A.P., India.
  • Ashok Thulluru Department of Pharmaceutical Quality Assurance, Shri Vishnu College of Pharmacy (Autonomous), Vishnupur, Bhimavaram-534 202, W.G. Dist., A.P., India

Abstract



Oral delivery of drug is the most preferable drug delivery due to the ease of administration, patient compliance and flexibility in the formulations. In recent era various technologies have been made in research and development of oral controlled release drug delivery system to overcome various physiological difficulties such as variation in gastric retention and emptying time. Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine and locally acting drugs in stomach get rapidly emptied. So, frequency of dose administration in such cases is increased. Gastro retentive drug delivery system (GRDDS) is facing many challenges which can be overcome by upcoming newly emerging approach, raft forming systems (RFS). The present study provides valuable information and highlights advances in this raft forming system. Different types of smart polymers used for their formulation have also been summarized. The current review focuses on the mechanism, formulation development and evaluation aspects of the raft forming systems and also highlights parameters which may lead to response variations in altered physiological conditions are discussed as well.           

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Keywords:

Raft forming systems, Gastro retentive drug delivery systems, Floating drug delivery systems, Gastrointestinal track, gastric residence time

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Published

2021-09-01

How to Cite

1.
G SM, M SN, P GM, M MV, Swamy PV, Thulluru A. Raft Forming Systems: A Novel Approach to Gastric Retention . Scopus Indexed [Internet]. 2021 Sep. 1 [cited 2024 Dec. 22];14(5):5594-602. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/2209

Issue

Vol. 14 No. 5 (2021): September-October 2021

Section

Review Articles
Crossref
Scopus
Google Scholar
Europe PMC

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