Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride
Thermosensitive Nala Gel of Meclizine HCL
DOI:
https://doi.org/10.37285/ijpsn.2022.15.1.6Abstract
Background: The current study was to develop a thermoreversible nasal in-situ gel for meclizine hydrochloride. As meclizine hydrochloride is water-insoluble and is having a hepatic first-pass metabolism it becomes necessary to prepare a formulation that will enhance the absorption of the drug and gives sustained action in the body.
Method: The FT-IR and DSC study revealed that there was no incompatibility between the drug and the excipient. The inclusion complex of meclizine hydrochloride was prepared by employing Sulfobutyl-ether- β- Cyclodextrin (SBEβCD) and then using this complex the thermoreversible gel was prepared by using the cold method. The thermoreversible gel was prepared by incorporating various types of polymers like Carrageenan, HPMC, carbopol-934, and Sodium Alginate in different concentrations and was evaluated for the various evaluation parameters to identify the optimized formulation from the batches B1-B8.
Result: From the prepared formulation B6 was found to be optimized as it was having a higher drug concentration of 98.33±2.1547%, the mucoadhesive strength of 28.98±1.5692 dyne/cm2 in B6 showed that more drug can be retained in the body as compared with other formulations, more sustained release of drug was seen i.e. 87.42±1.4113% of drug release in 8 hours than compared with the other prepared formulation. The kinetics study reveals peppas model was best fitted to the optimized formulation with the regression coefficient of 0.9832. From the stability study, it was concluded that the prepared formulation was stable during the full time study and does not change its property with time.
Conclusion: The concentration of polymers was a significant factor in the % drug release in the formulation and also in the mucoadhesive strength of the formulation. Hence, it was concluded that the prepared thermoreversible nasal in situ gel was a successful approach in increasing the drug absorption in the body.
Downloads
Metrics
Keywords:
Meclizine Hydrochloride, Nasal gel, Antihistamine, Poloxamer, Thermoreversible, In-situ
Downloads
Published
How to Cite
Issue
Section
References
Bisht, N., Goswami, L., & Kothiyal, P. (2014). Preparation and evaluation of in-situ oral topical gel of levofloxacin by using combination of polymers. Indian J Drugs, 2(4), 142- 151.
Bhandwalkar, M. J., & Avachat, A. M. (2013). Thermoreversible nasal in situ gel of venlafaxine hydrochloride: formulation, characterization, and pharmacodynamic evaluation. Aaps Pharmscitech, 14(1), 101-110.
Cai, Z., Song, X., Sun, F., Yang, Z., Hou, S., & Liu, Z. (2011). Formulation and evaluation of in situ gelling systems for intranasal administration of gastrodin. Aaps Pharmscitech, 12(4), 1102-1109.
Cao, S. L., Ren, X. W., Zhang, Q. Z., Chen, E., Xu, F., Chen, J., Jiang, X. G. (2009). In situ gel based on Sodium Alginate as new carrier for nasal administration of mometasone furoate. International journal of pharmaceutics, 365(1-2), 109-115.
Cao, S. L., Zhang, Q. Z., & Jiang, X. G. (2007). Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy. Acta Pharmacologica Sinica, 28(4), 584-590.
Fazil, M., Md, S., Haque, S., Kumar, M., Baboota, S., kaur Sahni, J., & Ali, J. (2012). Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting. European Journal of Pharmaceutical Sciences, 47(1), 6-15.
Galgatte, U. C., Kumbhar, A. B., & Chaudhari, P. D. (2014). Development of in situ gel for nasal delivery: design, optimization, in vitro and in vivo evaluation. Drug delivery, 21(1), 62-73.
Khandagale, P. M., Rokade, M. M., & Phadtare, D. G. (2018). Formulation Development and Evaluation of Nasal In-Situ Gel of Hydrocortisone. Asian Journal of Pharmacy and Technology, 8(2), 92-102.
Karavasili, C., & Fatouros, D. G. (2016). Smart materials: in situ gel-forming systems for nasal delivery. Drug discovery today, 21(1), 157-166.
Li, C., Li, C., Liu, Z., Li, Q., Yan, X., Liu, Y., & Lu, W. (2014). Enhancement in bioavailability of ketorolac tromethamine via intranasal in situ hydrogel based on poloxamer 407 and carrageenan. International journal of pharmaceutics, 474(1-2), 123-133.
Malviya, V. R., & Tawar, M. G. (2020). Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology, 13(1), 4745-4752.
Malviya, V., Thakur, Y., Gudadhe, S. S., & Tawar, M. (2020). Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology, 6(2), 94-100.
Malviya, V., & Manekar, S. (2021). Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology, 14(3), 1535-1541.
Malviya, V. R., Pande, S. D., & Bobade, N. N. (2019). Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology, 12(12), 5972-5976.
Malviya, V. (2021). Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research, 55(1), 86-94.
Malviya, V. R., & Pande, S. D. (2019). Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res, 8(8), 624-629.
Malviya, V., Ladhake, V., Gajbiye, K., Satao, J., & Tawar, M. (2020). Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology, 13(3), 4942-4951.
Pagar, S. A., Shinkar, D. M., & Saudagar, R. B. (2014). Development and evaluation of in situ nasal mucoadhesive gel of metoprolol succinate by using 32 full factorial design. Int J Pharm Pharm Sci, 6(11), 218-23.
Shelke, S., Shahi, S., Jalalpure, S., Dhamecha, D., & Shengule, S. (2015). Formulation and evaluation of thermoreversible mucoadhesive in-situ gel for intranasal delivery of naratriptan hydrochloride. Journal of drug delivery science and technology, 29, 238-244.
Song, J., Bi, H., Xie, X., Guo, J., Wang, X., & Liu, D. (2013). Preparation and evaluation of sinomenine hydrochloride in situ gel for uveitis treatment. International immunopharmacology, 17(1), 99-107.
Singh, R. M., Kumar, A., & Pathak, K. (2013). Thermally triggered mucoadhesive in situ gel of loratadine: β cyclodextrin complex for nasal delivery. AAPS PharmSciTech, 14(1), 412-424.
Ugwoke, M. I., Agu, R. U., Verbeke, N., & Kinget, R. (2005). Nasal mucoadhesive drug delivery: background,
applications, trends and future perspectives. Advanced drug delivery reviews, 57(11), 1640-1665.
Vangala, M., Veerareddy, P. R., Devadasu, V. R., & Vemula, S. K. (2014). Meclizine hydro chloride fast dissolving tablets by sublimation method: formulation and evaluation. American Journal of Advanced Drug Delivery, 2(2), 133-144.
Vibha, B. (2014). In-situ gel nasal drug delivery system-a review. International Journal of Pharma Sciences, 4(3), 577- 80.
Xu, X., Shen, Y., Wang, W., Sun, C., Li, C., Xiong, Y., & Tu, J. (2014). Preparation and in vitro characterization of
thermosensitive and mucoadhesive hydrogels for nasal delivery of phenylephrine hydrochloride. European Journal of Pharmaceutics and Biopharmaceutics, 88(3), 998-1004.
