Improvement of Solubility and Dissolution Rate of Simvastatin by Solid Dispersion Technique

DOI:

https://doi.org/10.37285/ijpsn.2019.12.6.3

Authors

  • Bhikshapathi D.V. R. N. Teegala Ram Reddy College of Pharmacy, Pragathi Colony, Meerpet, Hyderabad- 500097, Telangana, India.
  • Vishwaja M Vijaya College of Pharmacy, Hayath Nagar, Hyderabad - 501511, Telangana, India
  • Suthakaran R Vijaya College of Pharmacy, Hayath Nagar, Hyderabad - 501511, Telangana, India
  • Usha Sri B Vijaya College of Pharmacy, Hayath Nagar, Hyderabad - 501511, Telangana, India
  • M. Ratan Seshagiri Rao Keele University, Newcastle-under-Lyme, ST5 5BG, United Kingdom.

Abstract

The aim of present work is to enhance the solubility and bioavailability of Simvastatin by solid dispersion technique and characterize the same. Preliminary solubility studies were conducted to check the solubility in different polymers. Based on the results 20 formulations prepared by solvent evaporation method with varying ratios of Kleptose HPB, Soluplus, Kolliwax GMS II, Kolliphor P188 and PVPK-30. All the formulations were analyzed for solubility, percentage yield, drug content and in vitro drug release. The formulation SD20 with enhanced solubility of 20.05 ± 0.02μg/mL in Kolliwax GMS II, percentage yield of 99.13% and dissolution rate of 99.2 ± 2.3% within 90 min is chosen as optimized formulation. The formulation is further Characterized for Drug excipient interaction by FTIR, PXRD and SEM studies. The stability studies for 6 months indicated no significant changes in drug content or drug dissolution rate. Hence, improve dissolution characteristics of Simvastatin achieved by increasing its release and solubility through solid dispersion technique.

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Keywords:

Simvastatin, Lipid lowering agent, Solid dispersions, Solubility

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Published

2019-11-30

How to Cite

1.
D.V. R. N. B, M V, R S, B US, Rao MRS. Improvement of Solubility and Dissolution Rate of Simvastatin by Solid Dispersion Technique. Scopus Indexed [Internet]. 2019 Nov. 30 [cited 2024 Oct. 18];12(6):4964-700. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/232

Issue

Vol. 12 No. 6 (2019): November -December 2019

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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