Design and Evaluation of Telmisartan SMEDDS for Enhancing Solubility and Dissolution Rate

Abstract

Telmisartan belongs to a BCS class II drug i.e. low solubility and high permeability. It is an angiotensin II type-I receptor blocker essentially used for the treatment and curing of hypertension. The critical problem facing with telmisartan as it shows low solubility in biological fluids which results into less bioavailability after oral administration. The aim of the present work is to enhance the solubility, dissolution rate of telmisartan by formulating an optimal SMEDDS formulation. SMEDDS were prepared by admixing method using Peceol and Captex 200 as oil phases. Labrafil M2125 as surfactant and Transcutol and plurololeique as co-surfactants. Later they obtained liquid SMEDDS were converted in to free flowing powder using adsorbent like Aerosil 200. All the SMEDDS formulations were found to be stable and they were further evaluated for physical parameters such as phase separation, particle size and drug content. The formulation CT1 with oil to co-surfactant ratio 1:1 respectively showed highest rate of dissolution than the other ratios. The drug, excipients and optimized formulation were subjected to characterization studies such as FTIR and DSC studies shown that there were no interactions between drug and excipients used.