Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus

Abstract

The objective of the present study was to formulate the oral dispersible film of teneligliptin hydrobromide using Pullulan as a polymer and to evaluate it with the different parameters. The drug-excipients studies were carried out in order to determine any type of incompatibilities by using Fourier transmission infrared spectroscopy (FT-IR). The oral dispersible films were prepared using solvent casting method using Pullulan as a polymer. Propylene glycol was used as a plasticizer. The prepared films were evaluated for the parameters like physical appearance, thickness, folding endurance, In vitro disintegration, mechanical properties, surface pH, drug content uniformity, taste evaluation, in vitro dissolution test and stability study. The T6 formulation was found to be optimized, stable and appropriate in its evaluation parameters than compared to other formulations. The folding endurance was found to be 282 ± 1.59, disintegration time was found to be 05 ± 0.57, thickness was found to be 0.064±0.001, tensile strength was found to be 5.89, the % elongation was found to be 26.08, the maximum percentage drug release was found to be 95.90 % in 30 minutes. The drug content was found to be 99.90 with surface pH of 6.4. In the stability studies of the formulation the product was found to be stable for 90 days. The oral dispersible film is simple to administer and very much effective for the patients and the prepared film of teneligliptin proves to be potential candidate for safe and effective oral dispersible drug delivery.