Equator Assessment of Nanoparticles Using the Design-Expert Software
DOI:
https://doi.org/10.37285/ijpsn.2020.13.1.5Abstract
The main purpose of this attempt is to explore optimization techniques utilized in nano formulations using the Design-Expert software. In this field, the advanced nano formulations, such as nano emulsions, nanostructured lipids and other novel systems for drug delivery utilizes the core concepts of nanotechnology. Already established hypothesis is far better accepted than blindly experimenting; thus, the design expert® is the one of the most promising software utilized to design a formulation and expected results would speak about the concentration of the parameters to be taken. This article highlights the recent work done on nanoparticles and various designs used to optimize the preparations using Design expert. Here, data was collected from past work done in optimization techniques in making nano formulations from reputed journals and scientific papers. With growing science and technology, various factors in the pharmaceutical field had become trouble-free by incorporating such optimization technology (Design-expert software) that emerged in pharmaceutical research, especially for application and advancement of nanotechnology for designing novel delivery systems.
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Keywords:
Nano formulations, design, variables, pharmaceuticals, pharmaceuticals, design-expert software., design-expert software.
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Published
2020-01-31
How to Cite
1.
Hindustan Abdul A, Golla Bala A, Chintaginjala H, Manchikanti SP, Kamsali AK, Dasari RRD. Equator Assessment of Nanoparticles Using the Design-Expert Software. Scopus Indexed [Internet]. 2020 Jan. 31 [cited 2024 Nov. 22];13(1):4766-72. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/251
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References
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Ahmad N, Alam MA, Ahmad FJ, Sarafroz M, Ansari K and Sharma S (2018). Ultrasonication techniques used for the preparation of novel Eugenol-Nano-emulsion in the treatment of wounds healings and anti-inflammatory. J Drug Del Sci Tech 1(46): 461-73.
Belgamwar AV, Shagufta AK and Pramod GY (2019). Intranasal dolutegravir sodium loaded nanoparticles of hydroxypropyl-beta-cyclodextrin for brain delivery in Neuro-AIDS. J Drug Delivery Sci. Tech. 52: 1008-1020.
Bernela, Manju, Munish A and Rajesh T (2016). Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydrate Polymers. 143: 18-24.
Chauhan N, Dilbaghi N, Gopal M, Kumar R, Kim KH and Kumar S (2017). Development of chitosan nanocapsules for the controlled release of hexaconazole. Int J Biological Macromolecules. 97: 616-24.
Christoper GP, Raghavan CV, Siddharth K, Kumar MS, and Prasad RH (2014). Formulation and optimization of coated PLGA–Zidovudine nanoparticles using factorial design and in vitro in vivo evaluations to determine brain targeting efficiency. Saudi Pharm J. 22(2): 133-40.
Daman Z, Ostad S, Amini M, and Gilani K (2014). Preparation optimization and in vitro characterization of stearoyl-gemcitabine polymeric micelles: A comparison with its self-assembled nanoparticles. Int J Pharmaceutics. 468(1-2): 142-51.
Desai, Preshita P, and Vandana BP (2018). Curcumin cocrystal micelles—Multifunctional nanocomposites for management of neurodegenerative ailments. J Pharma Sci. 107(4): 1143-1156.
Dilbaghi N, Kaur H, Ahuja M, and Kumar S (2013). Evaluation of tropicamide-loaded tamarind seed xyloglucan nanoaggregates for ophthalmic delivery. Carbohydrate Polymers. 94(1): 286-91.
Ealias AM and Saravanakumar MP (2017). A review on the classification, characterisation, synthesis of nanoparticles and their application. In IOP Conf. Ser. Mater. Sci. Eng. 263, 32019.
Erdoğar N, Esendağlı G, Nielsen TT, Şen M, Oner L and Bilensoy E (2016). Design and optimization of novel paclitaxel-loaded folate-conjugated amphiphilic cyclodextrin nanoparticles. Int J Pharmaceutics. 509(1-2): 375-90.
Hansraj, Girotra P, Shailendra KS and Pawan K (2015). Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential. Int J Biological Macromolecules. 81: 467-476.
Jog, Rajan, Kenechi U and Diane JB (2016). Formulation design space for stable, pH sensitive crystalline nifedipine nanoparticles. Int J Pharmaceutics. 514: 81-92.
Joseph E, Reddi S, Rinwa V, Balwani G and Saha R (2017). Design and in vivo evaluation of solid lipid nanoparticulate systems of Olanzapine for acute phase schizophrenia treatment: Investigations on antipsychotic potential and adverse effects. European J Pharm Sci. 104: 315-25
Joseph E, Reddi S, Rinwa V, Balwani G and Saha R (2018). DoE based Olanzapine loaded poly-caprola-ctone nanoparticles decreases extrapyramidal effects in rodent model. Int J Pharmaceutics. 541(1-2): 198-205.
Jung T, Kamm W, Breitenbach A, Kaiserling E, Xiao JX and Kissel T (2000). Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake. European J Pharmaceutics and Biopharmaceutics. 50(1): 147-60.
Kaithwas V, Dora CP, Kushwah V and Jain S (2017). Nanostructured lipid carriers of olmesartan medoxomil with enhanced oral bioavailability. Colloids and Surfaces B: Biointerfaces. 154: 10-20.
Kaur H, Ahuja M, Kumar S, and Dilbaghi N (2012). Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery. Int J Biological Macromolecules. 50(3): 833-9.
Kesisoglou F, Panmai S, and Wu Y (2007). Nanosizing-oral formulation development and biopharmaceutical evaluation. Advanced Drug Delivery Reviews. 59(7): 631-44.
Khan AM, Ahmad FJ, Panda AK and Talegaonkar S (2016). Investigation of imatinib loaded surface decorated biodegradable nanocarriers against glioblastoma cell lines: Intracellular uptake and cytotoxicity studies. Int J Pharmaceutics. 507(1-2): 61-71.
Khan AM, Ahmad FJ, Panda AK, and Talegaonkar S (2016). Investigation of imatinib loaded surface decorated biodegradable nanocarriers against glioblastoma cell lines: Intracellular uptake and cytotoxicity studies. Int J Pharmaceutics. 507(1-2): 61-71.
Khan N, Khanna K, Bhatnagar A, Ahmad FJ, and Ali A (2018). Chitosan coated PLGA nanoparticles amplify the ocular hypotensive effect of forskolin: Statistical design, characterization and in vivo studies. Int J Biological Macromolecules. 116: 648-63.
Koradia KD, Rajesh HP, and Hiral DK (2018). Albendazole nanocrystals: Optimization, spectro-scopic, thermal and anthelmintic studies. J Drug Delivery Sci Tech. 43: 369-378
Kulkarni P, Deepak R, and Tejas B (2019). Formulation and optimization of long acting dual niosomes using box-Behnken experimental design method for combinative delivery of ethionamide and D-cycloserine in tuberculosis treatment. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 565: 131-142.
Kumar L, Reddy MS, Managuli RS, and Pai G (2015). Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles. Saudi Pharm J. 23(5): 549-55.
Kumar S, Bhanjana G, Sharma A, Sidhu MC, and Dilbaghi N (2014). Synthesis, characterization and on field evaluation of pesticide loaded sodium alginate nanoparticles. Carbohydrate Polymers. 101: 1061-7.
Kumar S, Kaur P, Bernela M, Rani R, and Thakur R (2016). Ketoconazole encapsulated in chitosan-gellan gum nanocomplexes exhibits prolonged antifungal activity. Int J Biological Macromolecules. 93: 988-94.
Kumar S, Narayan R, Ahammed V, Nayak Y, Naha A, and Nayak UY (2018). Development of ritonavir solid lipid nanoparticles by Box Behnken design for intestinal lymphatic targeting. J Drug Del Sci Tech. 44: 181-9.
Kumar S, Jie S, and Diane JB (2014). Nano-amorphous spray dried powder to improve oral bioavailability of itraconazole. J Controlled Release. 192: 95-102.
Li Y, Zhu CP, Zhai XC, Zhang Y, Duan Z, and Sun JR (2018). Optimization of enzyme assisted extraction of polysaccharides from pomegranate peel by response surface methodology and their anti-oxidant potential. Chinese Herbal Medicines. 10(4): 416-23.
Li YZ, Sun X, Gong T, Liu J, Zuo J, and Zhang ZR (2010). Inhalable microparticles as carriers for pulmonary delivery of thymopentin-loaded solid lipid nanoparticles. Pharmaceutical Research. 27(9): 1977-86.
Musa SH, Basri M, Masoumi HR, Karjiban RA, Malek EA, Basri H, and Shamsuddin AF (2013). Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment. Colloids and Surfaces B: Biointerfaces. 112: 113-9.
Musumeci T, Bonaccorso A, Carbone C, Russo G, Pappalardo F, and Puglisi G (2019). Design and optimization of PEGylated nanoparticles intended for Berberine Chloride delivery. J Drug Del Sci Tech. 52: 521-530.
Nagavarma BVN, Hemant KSY, Ayaz A, Vasudha LS, and Shivakumar HG (2012). Different techniques for preparation of polymeric nanoparticles-a review. Asian J. Pharm. Clin. Res. 3: 16-23.
Niyaz A, Farhan JA, Sumit B, Sonali S, Sadiq U, and Mohammad AA (2019). A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis. Saudi Pharm J. 27(6): 778-790.
Oktay AN, Karakucuk A, Ilbasmis-Tamer S, and Celebi N (2018). Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation. Euro J Pharm Sci. 122: 254-63.
Padhi S, Kapoor R, Verma D, Panda AK, and Iqbal Z (2018). Formulation and optimization of topotecan nanoparticles: in vitro characterization, cytotoxicity, cellular uptake and pharmacokinetic outcomes. J Photochemistry Photobiology B: Biology. 183: 222-32.
Pardeshi CV and Belgamwar VS (2018). N, N, N‑trimethyl chitosan modified flaxseed oil based mucoadhesive neuro nanoemulsions for direct nose to brain drug delivery. Int J Biological Macromolecules. 120: 2560-71.
Perez C, Sanchez A, Putnam D, Ting D, Langer R, and Alonso MJ (2001). Poly (lactic acid)-poly (ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J Controlled Release. 75(1-2): 211-24.
Raina H, Simrandeep K, and Anil BJ (2017). Development of efavirenz loaded solid lipid nano-particles: Risk assessment, quality-by-design (QbD) based optimisation and physicochemical characteri-sation. J Drug Del Sci Tech. 39: 180-191
Rani R, Dahiya S, Dhingra D, Dilbaghi N, Kim KH, and Kumar S (2017). Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats. Euro J Pharm Sci. 106: 220-30.
Rani R, Dilbaghi N, Dhingra D, and Kumar S (2015). Optimization and evaluation of bioactive drug-loaded polymeric nanoparticles for drug delivery. Int J Biological Macromolecules. 78: 173-9.
Rapalli VK, Khosa A, Singhvi G, Girdhar V, Jain R, and Dubey SK (2019). Application of QbD Principles in Nanocarrier-Based Drug Delivery Systems. Pharm Quality by Design. 255-296.
Ravi PR, Aditya N, Kathuria H, Malekar S, and Vats R (2014). Lipid nanoparticles for oral delivery of raloxifene: optimization, stability, in vivo evaluation and uptake mechanism. Euro J Pharm Biopharmaceutics. 87(1): 114-24.
Shaikh MV, Manika K, and Manish N (2017). Formulation and optimization of doxorubicin loaded polymeric nanoparticles using Box-Behnken design: ex-vivo stability and in-vitro activity. European J Pharm Sci. 100: 262-272.
Tureli NG, Akif ET, and Marc S (2016). Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach. Int J Pharmaceutics. 515(1-2): 343-351.
Vardhan H, Mittal P, Adena SK, and Mishra B (2017). Long-circulating polyhydroxybutyrate-co-hydroxy-valerate nanoparticles for tumor targeted docetaxel delivery: formulation, optimization and in vitro characterization. Euro J Pharm Sci. 99: 85-94.
Verma D, Thakur PS, Padhi S, Khuroo T, Talegaonkar S, and Iqbal Z (2017). Design expert assisted nanoformulation design for co-delivery of topotecan and thymoquinone: Optimization, in vitro characteri-zation and stability assessment. J Molecular Liquids 242: 382-94.
Want MY, Islamuddin M, Chouhan G, Dasgupta AK, Chattopadhyay AP, and Afrin F (2014). A new approach for the delivery of artemisinin: formulation, characterization, and ex-vivo antileishmanial studies. J Colloid and Interface Sci. 432: 258-69.
Ahmad N, Alam MA, Ahmad FJ, Sarafroz M, Ansari K and Sharma S (2018). Ultrasonication techniques used for the preparation of novel Eugenol-Nano-emulsion in the treatment of wounds healings and anti-inflammatory. J Drug Del Sci Tech 1(46): 461-73.
Belgamwar AV, Shagufta AK and Pramod GY (2019). Intranasal dolutegravir sodium loaded nanoparticles of hydroxypropyl-beta-cyclodextrin for brain delivery in Neuro-AIDS. J Drug Delivery Sci. Tech. 52: 1008-1020.
Bernela, Manju, Munish A and Rajesh T (2016). Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydrate Polymers. 143: 18-24.
Chauhan N, Dilbaghi N, Gopal M, Kumar R, Kim KH and Kumar S (2017). Development of chitosan nanocapsules for the controlled release of hexaconazole. Int J Biological Macromolecules. 97: 616-24.
Christoper GP, Raghavan CV, Siddharth K, Kumar MS, and Prasad RH (2014). Formulation and optimization of coated PLGA–Zidovudine nanoparticles using factorial design and in vitro in vivo evaluations to determine brain targeting efficiency. Saudi Pharm J. 22(2): 133-40.
Daman Z, Ostad S, Amini M, and Gilani K (2014). Preparation optimization and in vitro characterization of stearoyl-gemcitabine polymeric micelles: A comparison with its self-assembled nanoparticles. Int J Pharmaceutics. 468(1-2): 142-51.
Desai, Preshita P, and Vandana BP (2018). Curcumin cocrystal micelles—Multifunctional nanocomposites for management of neurodegenerative ailments. J Pharma Sci. 107(4): 1143-1156.
Dilbaghi N, Kaur H, Ahuja M, and Kumar S (2013). Evaluation of tropicamide-loaded tamarind seed xyloglucan nanoaggregates for ophthalmic delivery. Carbohydrate Polymers. 94(1): 286-91.
Ealias AM and Saravanakumar MP (2017). A review on the classification, characterisation, synthesis of nanoparticles and their application. In IOP Conf. Ser. Mater. Sci. Eng. 263, 32019.
Erdoğar N, Esendağlı G, Nielsen TT, Şen M, Oner L and Bilensoy E (2016). Design and optimization of novel paclitaxel-loaded folate-conjugated amphiphilic cyclodextrin nanoparticles. Int J Pharmaceutics. 509(1-2): 375-90.
Hansraj, Girotra P, Shailendra KS and Pawan K (2015). Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential. Int J Biological Macromolecules. 81: 467-476.
Jog, Rajan, Kenechi U and Diane JB (2016). Formulation design space for stable, pH sensitive crystalline nifedipine nanoparticles. Int J Pharmaceutics. 514: 81-92.
Joseph E, Reddi S, Rinwa V, Balwani G and Saha R (2017). Design and in vivo evaluation of solid lipid nanoparticulate systems of Olanzapine for acute phase schizophrenia treatment: Investigations on antipsychotic potential and adverse effects. European J Pharm Sci. 104: 315-25
Joseph E, Reddi S, Rinwa V, Balwani G and Saha R (2018). DoE based Olanzapine loaded poly-caprola-ctone nanoparticles decreases extrapyramidal effects in rodent model. Int J Pharmaceutics. 541(1-2): 198-205.
Jung T, Kamm W, Breitenbach A, Kaiserling E, Xiao JX and Kissel T (2000). Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake. European J Pharmaceutics and Biopharmaceutics. 50(1): 147-60.
Kaithwas V, Dora CP, Kushwah V and Jain S (2017). Nanostructured lipid carriers of olmesartan medoxomil with enhanced oral bioavailability. Colloids and Surfaces B: Biointerfaces. 154: 10-20.
Kaur H, Ahuja M, Kumar S, and Dilbaghi N (2012). Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery. Int J Biological Macromolecules. 50(3): 833-9.
Kesisoglou F, Panmai S, and Wu Y (2007). Nanosizing-oral formulation development and biopharmaceutical evaluation. Advanced Drug Delivery Reviews. 59(7): 631-44.
Khan AM, Ahmad FJ, Panda AK and Talegaonkar S (2016). Investigation of imatinib loaded surface decorated biodegradable nanocarriers against glioblastoma cell lines: Intracellular uptake and cytotoxicity studies. Int J Pharmaceutics. 507(1-2): 61-71.
Khan AM, Ahmad FJ, Panda AK, and Talegaonkar S (2016). Investigation of imatinib loaded surface decorated biodegradable nanocarriers against glioblastoma cell lines: Intracellular uptake and cytotoxicity studies. Int J Pharmaceutics. 507(1-2): 61-71.
Khan N, Khanna K, Bhatnagar A, Ahmad FJ, and Ali A (2018). Chitosan coated PLGA nanoparticles amplify the ocular hypotensive effect of forskolin: Statistical design, characterization and in vivo studies. Int J Biological Macromolecules. 116: 648-63.
Koradia KD, Rajesh HP, and Hiral DK (2018). Albendazole nanocrystals: Optimization, spectro-scopic, thermal and anthelmintic studies. J Drug Delivery Sci Tech. 43: 369-378
Kulkarni P, Deepak R, and Tejas B (2019). Formulation and optimization of long acting dual niosomes using box-Behnken experimental design method for combinative delivery of ethionamide and D-cycloserine in tuberculosis treatment. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 565: 131-142.
Kumar L, Reddy MS, Managuli RS, and Pai G (2015). Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles. Saudi Pharm J. 23(5): 549-55.
Kumar S, Bhanjana G, Sharma A, Sidhu MC, and Dilbaghi N (2014). Synthesis, characterization and on field evaluation of pesticide loaded sodium alginate nanoparticles. Carbohydrate Polymers. 101: 1061-7.
Kumar S, Kaur P, Bernela M, Rani R, and Thakur R (2016). Ketoconazole encapsulated in chitosan-gellan gum nanocomplexes exhibits prolonged antifungal activity. Int J Biological Macromolecules. 93: 988-94.
Kumar S, Narayan R, Ahammed V, Nayak Y, Naha A, and Nayak UY (2018). Development of ritonavir solid lipid nanoparticles by Box Behnken design for intestinal lymphatic targeting. J Drug Del Sci Tech. 44: 181-9.
Kumar S, Jie S, and Diane JB (2014). Nano-amorphous spray dried powder to improve oral bioavailability of itraconazole. J Controlled Release. 192: 95-102.
Li Y, Zhu CP, Zhai XC, Zhang Y, Duan Z, and Sun JR (2018). Optimization of enzyme assisted extraction of polysaccharides from pomegranate peel by response surface methodology and their anti-oxidant potential. Chinese Herbal Medicines. 10(4): 416-23.
Li YZ, Sun X, Gong T, Liu J, Zuo J, and Zhang ZR (2010). Inhalable microparticles as carriers for pulmonary delivery of thymopentin-loaded solid lipid nanoparticles. Pharmaceutical Research. 27(9): 1977-86.
Musa SH, Basri M, Masoumi HR, Karjiban RA, Malek EA, Basri H, and Shamsuddin AF (2013). Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment. Colloids and Surfaces B: Biointerfaces. 112: 113-9.
Musumeci T, Bonaccorso A, Carbone C, Russo G, Pappalardo F, and Puglisi G (2019). Design and optimization of PEGylated nanoparticles intended for Berberine Chloride delivery. J Drug Del Sci Tech. 52: 521-530.
Nagavarma BVN, Hemant KSY, Ayaz A, Vasudha LS, and Shivakumar HG (2012). Different techniques for preparation of polymeric nanoparticles-a review. Asian J. Pharm. Clin. Res. 3: 16-23.
Niyaz A, Farhan JA, Sumit B, Sonali S, Sadiq U, and Mohammad AA (2019). A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis. Saudi Pharm J. 27(6): 778-790.
Oktay AN, Karakucuk A, Ilbasmis-Tamer S, and Celebi N (2018). Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation. Euro J Pharm Sci. 122: 254-63.
Padhi S, Kapoor R, Verma D, Panda AK, and Iqbal Z (2018). Formulation and optimization of topotecan nanoparticles: in vitro characterization, cytotoxicity, cellular uptake and pharmacokinetic outcomes. J Photochemistry Photobiology B: Biology. 183: 222-32.
Pardeshi CV and Belgamwar VS (2018). N, N, N‑trimethyl chitosan modified flaxseed oil based mucoadhesive neuro nanoemulsions for direct nose to brain drug delivery. Int J Biological Macromolecules. 120: 2560-71.
Perez C, Sanchez A, Putnam D, Ting D, Langer R, and Alonso MJ (2001). Poly (lactic acid)-poly (ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J Controlled Release. 75(1-2): 211-24.
Raina H, Simrandeep K, and Anil BJ (2017). Development of efavirenz loaded solid lipid nano-particles: Risk assessment, quality-by-design (QbD) based optimisation and physicochemical characteri-sation. J Drug Del Sci Tech. 39: 180-191
Rani R, Dahiya S, Dhingra D, Dilbaghi N, Kim KH, and Kumar S (2017). Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats. Euro J Pharm Sci. 106: 220-30.
Rani R, Dilbaghi N, Dhingra D, and Kumar S (2015). Optimization and evaluation of bioactive drug-loaded polymeric nanoparticles for drug delivery. Int J Biological Macromolecules. 78: 173-9.
Rapalli VK, Khosa A, Singhvi G, Girdhar V, Jain R, and Dubey SK (2019). Application of QbD Principles in Nanocarrier-Based Drug Delivery Systems. Pharm Quality by Design. 255-296.
Ravi PR, Aditya N, Kathuria H, Malekar S, and Vats R (2014). Lipid nanoparticles for oral delivery of raloxifene: optimization, stability, in vivo evaluation and uptake mechanism. Euro J Pharm Biopharmaceutics. 87(1): 114-24.
Shaikh MV, Manika K, and Manish N (2017). Formulation and optimization of doxorubicin loaded polymeric nanoparticles using Box-Behnken design: ex-vivo stability and in-vitro activity. European J Pharm Sci. 100: 262-272.
Tureli NG, Akif ET, and Marc S (2016). Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach. Int J Pharmaceutics. 515(1-2): 343-351.
Vardhan H, Mittal P, Adena SK, and Mishra B (2017). Long-circulating polyhydroxybutyrate-co-hydroxy-valerate nanoparticles for tumor targeted docetaxel delivery: formulation, optimization and in vitro characterization. Euro J Pharm Sci. 99: 85-94.
Verma D, Thakur PS, Padhi S, Khuroo T, Talegaonkar S, and Iqbal Z (2017). Design expert assisted nanoformulation design for co-delivery of topotecan and thymoquinone: Optimization, in vitro characteri-zation and stability assessment. J Molecular Liquids 242: 382-94.
Want MY, Islamuddin M, Chouhan G, Dasgupta AK, Chattopadhyay AP, and Afrin F (2014). A new approach for the delivery of artemisinin: formulation, characterization, and ex-vivo antileishmanial studies. J Colloid and Interface Sci. 432: 258-69.
