A Detailed Review on Porous Microspheres: Methods of Preparation, Characterization, and its Applications
DOI:
https://doi.org/10.37285/ijpsn.2023.16.5.7Abstract
Porous microspheres are a new kind of carrier with high porosity, uniform porous structure, and pore size with narrow distribution. They are having inter-connective pores present externally and internally which leads to very low mass density and greater specific surface area, making them have excellent adsorption properties. Because of this uniqueness over non-porous microspheres, they are having extensive pharmaceutical applications. Porous microspheres are formulated by several methods, which involve the use of porogens or templating agents for the formation of pores, self-forming pores by particle matrices without any pore-forming agents, and chemical synthesis. These microspheres are very promising in varied fields of medicine such as enhancing of dissolution of poorly soluble drugs, developing novel drug delivery systems, and improving the functional properties of drug-loaded particles. The main factor governing their applications depends on the pore structure and porosity. Therefore, this review aims at emphasizing the principles underlying the development and evaluation of porous microspheres as a controlled and targeted drug delivery system and becomes an informative reference that can be beneficial for several interested research scholars.
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Porous, Microspheres, Porogens, PorosityDownloads
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