Development and Evaluation of Mucolytic Fast Dissolving Oral Film Containing Ambroxol, Guainphenesin and Levosalbutamol
DOI:
https://doi.org/10.37285/ijpsn.2020.13.2.8Abstract
The bitter taste of the drugs often causes unacceptability among the patient population that may spoil the purpose of the fabricated film, as drug sensitivity is highest in the buccal area. The present research aimed at developing and evaluation of fast dissolving oral films with taste-masked attributes using β-cyclodextrin of mucolytic agents such as ambroxol, guainphenesin, and levosalbutamol for application in numerous bronchial conditions for patients having medical conditions of dysphasia. The fabricated fast oral dissolving film provided effective delivery of the drug with reduced metabolism and high therapeutic efficacy. The combination of polymers (HPMC K15 and pectin), disintegrants, sweeteners, and complexing agent (β-cyclodextrin) offered taste-masking drugs loaded (ambroxol, guainphenesin, and levosalbutamol) films. The formulation-1 was found to be the most optimized batch. The films made from the combination of HPMC K15M and pectin showed excellent film formation can be formulated for pediatric and geriatric patients. The present research will definitely overcome all the limitations of conventional dosages form and will open new utilities and avenues for rationally developing and commercializing mucolytic film formulations in the near future.
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Keywords:
Oral film, Fast dissolving, Taste masking, Mucolytic drugs, Ambroxol, Guainphenesin, Levosalbutamol
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Published
2020-03-31
How to Cite
1.
Telrandhe R, Mahajan NM, Kankariya E, Mahapatra DK, Gangane PS. Development and Evaluation of Mucolytic Fast Dissolving Oral Film Containing Ambroxol, Guainphenesin and Levosalbutamol. Scopus Indexed [Internet]. 2020 Mar. 31 [cited 2024 Dec. 22];13(2):4857-65. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/264
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Research Articles
References
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Maheswari KM, Devineni PK, Deekonda S, Shaik S, Uppala NP, and Nalluri BN (2014). Development and evaluation of mouth dissolving films of amlodipine besylate for enhanced therapeutic efficacy. J Pharm 2014:1-10.
Patil MD, Mahapatra DK, and Dangre PV (2016). Formulation and in-vitro evaluation of once-daily sustained release matrix tablet of nifedipine using rate retardant polymers. Inventi Rapid Pharm Tech 4:1-7.
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Singh H, Kaur M and Verma H (2013). Optimization and evaluation of desloratadine oral strip: an innovation in paediatric medication. The Scientific World J 2013:1-9.
Sultana F, Arafat M and Pathan SI (2013). Preparation and evaluation of fast dissolving oral thin film of caffeine. Int J Pharm Biol Sci 3(1):153-161.
Umekar MJ, Bano SG, Younus M and Fatima AN (2017). Formulation and characterization of pediatric paracetamol oral mouth dissolving film. Int J Res Pharm Sci 8(3): 397-402.
Alipour S, Akbari S, and Ahmadi F (2015). Development and in vitro evaluation of fast-dissolving oral films of ondansetron hydrochloride. Trends Pharm Sci 1(1):25-30.
Bala R, Khanna S, and Pawar P (2014). Design optimization and in vitro-in vivo evaluation of orally dissolving strips of clobazam. J Drug Delivery 2014:1-15.
Bawane S, Telrandhe R, and Pande SD (2018). Formulation and Evaluation of Oral Fast Dissolving Film of Bisoprolol Fumarate. Int J Pharm Drug Anal 6(2):105-115.
Bhikshapathi DV, Madhuri VD, Rajesham VV, and Suthakaran R (2014). Preparation and evaluation of fast dissolving oral film containing Naratriptan HCl. Am J Pharm Tech Res 4(2):799-812.
Bonsu MA, Ofori-Kwakye K, Kipo SL, Boakye-Gyasi ME, and Fosu MA (2016). Development of oral dissolvable films of diclofenac sodium for osteoarthritis using Albizia and Khaya gums as hydrophilic film formers. J Drug Deliv 2016:1-11.
Dangre PV, Godbole MD, Ingale PV, and Mahapatra DK (2016). Improved dissolution and bioavailability of eprosartan mesylate formulated as solid dispersions using conventional methods. Indian J Pharm Edu Res 50(3):S209-S217.
Godbole MD, Mahapatra DK, and Khode PD (2017). Fabrication and Characterization of Edible Jelly Formulation of Stevioside: A Nutraceutical or OTC Aid for the Diabetic Patients. Inventi Nutraceut 2017(2):1-9.
Jaafar IS (2017). Formulation and In vitro Evaluation of Fast Dissolving Film of Metoclopramide Hydrochloride. Int J ChemTech Res 10:26-38.
Kathpalia H and Patil A (2017). Formulation and Evaluation of Orally Disintegrating Films of Levocetirizine Dihydrochloride. Indian J Pharm Sci 79(2):204-211.
Khatoon N, Rao NR, and Reddy BM (2014). Formulation and evaluation of oral fast dissolving films of montelukast sodium. Int J Pharm Sci Res 5(5):1780-1785.
Kokare CK, Tagalpallewar AA, Aragade PS, Bagul US, Bacchav RK, and Nanjwade BK (2015). Formulation, evaluation and optimization of asenapine maleate fast mouth dissolving film. J Pharm Sci Pharmacol 2(3):194-207.
Krishna KD, Pradip ST, and Navin SR (2017). Preparation and Optimization of Fast Dissolving Film of Naratr iptan Hydrochloride. Recent Pat Drug Delivery Formul 11(2):124-131.
Lai KL, Fang Y, Han H, Li Q, Zhang S, Li HY, Chow SF, Lam TN, and Lee WY (2018). Orally-dissolving film for sublingual and buccal delivery of ropinirole. Coll Surf B Biointerf 163:9-18.
Liew KB, Tan YT, and Peh KK (2012). Characterization of oral disintegrating film containing donepezil for Alzheimer disease. AAPS Pharm Sci Tech 13(1):134-142.
Londhe VY and Umalkar KB (2012). Formulation development and evaluation of fast dissolving film of telmisartan. Indian J Pharm Sci 74(2):122-126.
Mahajan A (2012). Formulation & evaluation of fast dissolving buccal films of sertraline. Int J Drug Devel Res 4(1):220-226.
Mahesh A, Shastri N, and Sadanandam M (2010). Development of taste masked fast disintegrating films of levocetirizine dihydrochloride for oral use. Curr Drug Deliv 7(1):21-27.
Maheswari KM, Devineni PK, Deekonda S, Shaik S, Uppala NP, and Nalluri BN (2014). Development and evaluation of mouth dissolving films of amlodipine besylate for enhanced therapeutic efficacy. J Pharm 2014:1-10.
Patil MD, Mahapatra DK, and Dangre PV (2016). Formulation and in-vitro evaluation of once-daily sustained release matrix tablet of nifedipine using rate retardant polymers. Inventi Rapid Pharm Tech 4:1-7.
Pethe AM and Desai RB (2016). Formulation, optimization & evaluation of mouth dissolving film of nifedipine by using design of experiment. Asian J Pharm Sci 11:74-76.
Senthilkumar K and Vijaya C (2015). Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management. Adv Pharmaceut 2015:1-11.
Shah JN, Shah KN and Mehta TA (2015). Hydroxy propyl β-cyclodextrin complexation of promethazine hydrochloride for the formulation of fast dissolving sublingual film: in vitro and in vivo evaluation. J Pharm Investig 45(1):91-99.
Singh H, Kaur M and Verma H (2013). Optimization and evaluation of desloratadine oral strip: an innovation in paediatric medication. The Scientific World J 2013:1-9.
Sultana F, Arafat M and Pathan SI (2013). Preparation and evaluation of fast dissolving oral thin film of caffeine. Int J Pharm Biol Sci 3(1):153-161.
Umekar MJ, Bano SG, Younus M and Fatima AN (2017). Formulation and characterization of pediatric paracetamol oral mouth dissolving film. Int J Res Pharm Sci 8(3): 397-402.
