Formulation and Evaluation of Fast Dissolving Meben-dazole Tablets using Different Superdisintegrants

Abstract

In this investigation fast dissolving tablets of mebendazole were prepared using different super disintegrants such as microcrystalline cellulose, sodium starch glycolate and crospovidone by direct compression method. This study was aimed to increase the bioavailability of mebendazole by formulating it as fast dissolving tablets by direct compression method. Mebendazole is an antihelminthic drug used for treatment of parasitic infections. Fast dissolving tablets were evaluated for physico-chemical properties and in vitro dissolution. Disintegration time and 

wetting time of formulations containing microcrystalline cellulose and sodium starch glycolate was least and tablets showed fastest disintegration, faster disintegration time 60±1.52 sec and showed maximum in vitro drug release 98. 82% at the end of 16 minutes. Kinetic data analysis showed that F3 follows zero order release with Korsmeyer-Peppas model showing Non-Fickian case II transport mechanism. The stability studies indicated that there was no significant change in hardness, friability, disintegration time, wetting time, in vitro drug release study.