Nanoneedle Mediated Delivery of Silver for Topical Therapies
DOI:
https://doi.org/10.37285/ijpsn.2019.12.4.6Abstract
We explored the nanoneedles− a novel nanostructured material (NSM) fabricated by nanofabrication techniques and assessed their suitability as a carrier for delivery of silver drug cargo. We achieved individual nanoneedles with tip diameter of 220-250 nm, desired micro-scale length, high Young’s modulus (~100 GPa), and large external surfaces. Owing to large external surfaces of nanoneedles compared to micro-carriers utilized to deliver cargo of drug substances for topical drug delivery. Drug molecules were conjugated on nanoneedle surface and then released by means of predesigned surface chemistry. SEM, TEM, FTIR, XRD and TGA confirmed surface morphologies, structure of nanoneedles. SQUID magneto-meter was used to ascertain the magnetic behavior of nanoneedles. In vivo methods were carried out to assess wound healing potential of Silver Chitosan nanoneedle, wherein it shows the better results for wound healing. Thus, it could provide better scaffold for wound healing in near future.
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Keywords:
Nanoneedles, Nanomedicine, Nanofabrication, Wound healing, Magnetic properties
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Published
2019-07-31
How to Cite
1.
B.S. W, Bhatia N. Nanoneedle Mediated Delivery of Silver for Topical Therapies. Scopus Indexed [Internet]. 2019 Jul. 31 [cited 2024 Dec. 22];12(4):4600-12. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/309
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Research Articles
References
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He P, Stanley S. Davis, and Lisbeth Illum (1998). In Vitro Evaluation of the Mucoadhesive Properties of Chitosan Microspheres. International Journal of Pharmaceutics 166(1): 75-88.
Illum L (1998). Chitosan and Its Use as a Pharmaceutical Excipient. Pharmaceutical research 15(9): 1326-31.
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Nakatsuka S and Anthony L. Andrady (1992). Permeability of Vitamin B-12 in Chitosan Membranes. Effect of Crosslinking and Blending with Poly(Vinyl Alcohol) on Permeability. Journal of Applied Polymer Science 44(1): 17-28.
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Sawayanagi Y, N Nambu, and T Nagai (1982). Use of Chitosan for Sustained-Release Preparations of Water-Soluble Drugs. Chemical & Pharmaceutical Bulletin 30(11): 4213-15.
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Tozaki H, T Fujita, T Odoriba, A Terabe, T Suzuki, et al (1999). Colon-Specific Delivery of R68070, a New Thromboxane Synthase Inhibitor, Using Chitosan Capsules: Therapeutic Effects against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis in Rats. Life Sciences 64(13): 1155-62.
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Zikakis and John P. (1984). Chitin, Chitosan, and Related Enzymes. ed. John P Zikakis. New York: Academic Press Inc.
Atala A, James RL, Thomson A and Nerem R (2011). Front Matter. In Principles of Regenerative Medicine, Amsterdam, Netherlands,: Elsevier
Davis SS and Illum L (1999). Sustained Release Chitosan Microspheres Prepared by Novel Spray Drying Methods. Journal of Microencapsulation 16(3): 343-55.
He P, Stanley S. Davis, and Lisbeth Illum (1998). In Vitro Evaluation of the Mucoadhesive Properties of Chitosan Microspheres. International Journal of Pharmaceutics 166(1): 75-88.
Illum L (1998). Chitosan and Its Use as a Pharmaceutical Excipient. Pharmaceutical research 15(9): 1326-31.
Karlsmark T et al (2003). Clinical Performance of a New Silver Dressing, Contreet Foam, for Chronic Exuding Venous Leg Ulcers. Journal of Wound Care 12(9): 351-54.
Kubota N, Kazuya Ohga, and Mitsuaki Moriguchi (1991). Permeability Properties of Glycol Chitosan Membrane Modified with Thiol Groups. Journal of Applied Polymer Science 42(2): 495-501.
Landsdown AB and A Williams (2007). Bacterial Resistance to Silver in Wound Care and Medical Devices. J Wound Care 16(1): 15-19.
Lansdown ABG (2004). A Review of the Use of Silver in Wound Care: Facts and Fallacies. British Journal of Nursing 13(Sup1): S6-19.
Leong KW et al (1998). DNA-Polycation Nanospheres as Non-Viral Gene Delivery Vehicles. Journal of controlled release: official journal of the Controlled Release Society 53(1-3): 183-93.
Lewcock A (2007). Carbon Nanoneedles for Drug Delivery. In-Pharma Technologist.
Li, Q., E.T. Dunn, E.W. Grandmaison, and M.F.A. Goosen. 1992. Applications and Properties of Chitosan. Journal of Bioactive and Compatible Polymers 7(4): 370-97.
Lu L et al (2013). Silver Nanoparticle/Chitosan Oligosaccharide/ Poly(Vinyl Alcohol) Nanofibers as Wound Dressings: A Preclinical Study. International Journal of Nanomedicine 8: 4131-45.
Lueben HL et al. (1994). Bioadhesive Polymers for the Peroral Delivery of Peptide Drugs. Journal of Controlled Release 29(3): 329-38.
Lueben HL et al. (1997). Mucoadhesive Polymers in Peroral Peptide Drug Delivery. IV. Polycarbophil and Chitosan are Potent Enhancers of Peptide Transport across Intestinal Mucosae in Vitro. Journal of Controlled Release 45(1): 15-23.
Miyazaki S et al. (1988). Sustained-Release and Intragastric-Floating Granules of Indomethacin Using Chitosan in Rabbits. Chemical & Pharmaceutical Bulletin 36(10): 4033-38.
Muzzarelli RAA (1973). Natural Chelating Polymers. Pergamon Press.
Muzzarelli RAA (1977). Chitin. New York: Pergamon Press.
Nakatsuka S and Anthony L. Andrady (1992). Permeability of Vitamin B-12 in Chitosan Membranes. Effect of Crosslinking and Blending with Poly(Vinyl Alcohol) on Permeability. Journal of Applied Polymer Science 44(1): 17-28.
Paul W and CP Sharma (2000). Chitosan, a Drug Carrier for the 21st Century: A Review. S.T.P. Pharma Sciences 10(1): 5-22.
Ravi Kumar MNV (2000). A Review of Chitin and Chitosan Applications. Reactive and Functional Polymers 46(1): 1-27.
Robert BE (2003). A Scientific Perspective on the Use of Topical Silver Preparations. Ostomy/wound management 49(5A Suppl): 19-24.
Russell AD and WB Hugo (1994). Antimicrobial Activity and Action of Silver. Prog Med Chem 31: 351-70.
Sawayanagi Y, N Nambu, and T Nagai (1982). Use of Chitosan for Sustained-Release Preparations of Water-Soluble Drugs. Chemical & Pharmaceutical Bulletin 30(11): 4213-15.
Singla AK and M Chawla (2001). Chitosan: Some Pharmaceutical and Biological Aspects--an Update. Journal of Pharmacy and Pharmacology 53(8): 1047-67.
Tozaki H, T Fujita, T Odoriba, A Terabe, S Okabe, et al. (1999). Validation of a Pharmacokinetic Model of Colon-Specific Drug Delivery and the Therapeutic Effects of Chitosan Capsules Containing 5-Aminosalicylic Acid on 2,4,6-Trinitrobenzene-sulphonic Acid-Induced Colitis in Rats. Journal of Pharmacy and Pharmacology 51(10): 1107-12.
Tozaki H, T Fujita, T Odoriba, A Terabe, T Suzuki, et al (1999). Colon-Specific Delivery of R68070, a New Thromboxane Synthase Inhibitor, Using Chitosan Capsules: Therapeutic Effects against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis in Rats. Life Sciences 64(13): 1155-62.
Valérie D and Vilivalam VD (1998). Pharmaceutical Applications of Chitosan. Pharmaceutical Science & Technology Today 1(6): 246-53.
Vieru T (2009). Nanoneedles May Change the Face of Medicine. Softpedia.
Zikakis and John P. (1984). Chitin, Chitosan, and Related Enzymes. ed. John P Zikakis. New York: Academic Press Inc.
