Cashew Nut Starch as Natural Excipient for Improved Bioavailability of Drugs
DOI:
https://doi.org/10.37285/ijpsn.2019.12.4.8Abstract
The bioavailability of drug is affected by various excipients present in the formulation. In case of tablets, the role of binders is very important for release of drug and bioavailability. In the present study, starch was extracted from the cashew nuts and used as binding agentat a concentration of 2% w/v, 4% w/v, 6% w/v and 8% w/v. The tablets were formulated by using famotidine drug and they were further evaluated for various parameters like weight variation, hardness, friability, disintegration time, in vitro and in vivo drug release. The results show that all parameters were found within the given Indian Pharmacopeial limits. The in vitro release studies were performed in 0.1 N HCl using dialysis methods. This shows that tablets containing 2 % of cashew starch showed maximum drug release (89%) then other formulations. Then optimized formulation was further used for in vivo study and results shows better bioavailability as compared to marketed products.
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Keywords:
Starch, Binder, Dissolution, Bioavailability, Famotidine, In vitro-in vivo correlation.
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Published
2019-07-31
How to Cite
1.
Kushwaha A. Cashew Nut Starch as Natural Excipient for Improved Bioavailability of Drugs. Scopus Indexed [Internet]. 2019 Jul. 31 [cited 2024 Nov. 19];12(4):4616-22. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/311
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Research Articles
References
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Kolawole SA, Igwemmar NC and Bello HA (2013). Comparison of the physicochemical properties of starch from ginger (Zingiberofficinale) and Maize (Zea mays),International Journal of Science and Research 2(11): 71-76.
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Okoye EI, Ekweogu AC and Oruna UE (2017). Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide. Journal of Pharmacy & Pharmacognosy Research. 5(1): 15-28.
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Puri AV, Puranik VK, Kamble MD and Tauro SJ (2013). Formulation and evaluation of diclofenac sodium tablet using isolated starch from unripe papaya fruits as disintegrants. Indo American Journal of Pharmaceutical Research 3(11): 9183-9189.
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Satyam G, Shivani S, Garima G, Nitin S and Sharma PK (2010). Isolation and evaluation of binding property of pappaya starch in diclofenac sodium tablet. International Journal of Pharm Tech Research 2(2): 1508-1512.
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Singh AV and Nath LK (2013). Evaluation of chemically modified hydrophobic sago starch as a carrier for controlled drug delivery. Saudi Pharmaceutical Journal 21(2): 193-200.
Usman M, Ishfaq MT, Malik SR, Iqbal M, and Ishfaq B (2014). Alkaline extraction of starch from broken rice of pakistan. International Journal of Innovation and Applied Studies 7(1): 146-152.
Varma VK (2016). Excipients used in the formulation of tablets. Research and Reviews: Journal of Chemistry 5(2): 143-154.
Barad R, Soni P, Upadhyay MS and Upadhyay U (2013). Withaniacoagulans and Psidium guajava- an overview. International Research Journal of Pharmaceutical and Applied Sciences 3(3): 42-47.
Chatap VK and Patil SD (2016). In-vitro and in-vivo consideration of repaglinide immediate-release tablet: assessment of porous acetostarch as a promising carrier for dissolution rate enhancement. Food Science and Technology 4(4): 78-88.
Chitedze J, Monjerezi M, Saka JDK and Steenkamp J (2012). Binding effect of cassava starches on the compression and mechanical properties of Ibuprofen tablets. Journal of Applied Pharmaceutical Science 2(04): 31-37.
Debnath S, Gayathri VG and Babu MN (2013). Chemically modified starches and their applications in pharmacy. International Journal of Research in Pharmaceutical and Nano Sciences 2(3): 332 -344.
Hartesi B, Sriwidodo C, Abdassah M and Chaerunisaa AY (2016). Starch as Pharmaceutical Excipient. Int. J. Pharm. Sci. Rev. Res 41(2): 59-64.
Hussain A, Farah Qureshi, Nasir Abbas, Muhammad Sohail Arshad and Ejaz Ali (2017). An evaluation of the binding strength of okra gum and the drug release characteristics of tablets prepared from it. Pharmaceutics 9(2): 20.
Ibezim EC, Ofoefule SI, Omeje EO, Onyishi VI and Odoh UE (2008).The role of ginger starch as a binder in acetaminophen tablets. Academic Journal 3(2): 46-50.
Jaya S, Chowdary KPR, and Rajeswara Rao P (2012). Effect of binders on the dissolution rate and dissolution efficiency of ritonavir tablets. Int. Res J Pharm. App Sci. 2(5): 224-229.
Khule NR, Mahale NB, Shelar DS, Rokade MM, Chaudhari SR (2012), “Extraction of pectin from citrus fruit peel and use as natural binder in paracetamol tablet”, Scholars Research Library 4(2): 558-564.
Kolawole SA, Igwemmar NC and Bello HA (2013). Comparison of the physicochemical properties of starch from ginger (Zingiberofficinale) and Maize (Zea mays),International Journal of Science and Research 2(11): 71-76.
Kumar A (2012). Importance for life Psidium guava. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(1): 137-148.
Manchanda R, Shrivastava B, Arora SC and Manchanda R (2015). Formulation, evaluation and optimization of tamarind seed polysaccharide based glipizide sustained release matrix tablets by 32 full factorial design. International Journal of PharmTech Research 7(2): 380-391.
Okoye EI, Ekweogu AC and Oruna UE (2017). Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide. Journal of Pharmacy & Pharmacognosy Research. 5(1): 15-28.
Panakanti R and Narang AS (2012). Impact of excipient interactions on drug bioavailability from solid dosage forms, Pharm Res 29(10): 2639-59.
Puri AV, Puranik VK, Kamble MD and Tauro SJ (2013). Formulation and evaluation of diclofenac sodium tablet using isolated starch from unripe papaya fruits as disintegrants. Indo American Journal of Pharmaceutical Research 3(11): 9183-9189.
Rao BSS (2012). Factors Effecting Bioavailability Studies. The Pharma Innovation 1(3): 01-05.
Satyam G, Shivani S, Garima G, Nitin S and Sharma PK (2010). Isolation and evaluation of binding property of pappaya starch in diclofenac sodium tablet. International Journal of Pharm Tech Research 2(2): 1508-1512.
Satyam G, Shivani S, Shobhit GSJ, Sanjeev V and Arvind K (2010). Starch as a material for drug delivery. International Journal of Biological & Pharmaceutical Research 1(2): 56-60.
Shailendra P, Shikha A and Singh LB (2012). Natural binding agents in tablet formulation. International Journal of Pharmaceutical & Biological Archives 3(3): 466-473.
Singh AV and Nath LK (2013). Evaluation of chemically modified hydrophobic sago starch as a carrier for controlled drug delivery. Saudi Pharmaceutical Journal 21(2): 193-200.
Usman M, Ishfaq MT, Malik SR, Iqbal M, and Ishfaq B (2014). Alkaline extraction of starch from broken rice of pakistan. International Journal of Innovation and Applied Studies 7(1): 146-152.
Varma VK (2016). Excipients used in the formulation of tablets. Research and Reviews: Journal of Chemistry 5(2): 143-154.
