Review of Atypical Lipoma and its Natural Treatment
DOI:
https://doi.org/10.37285/ijpsn.2019.12.5.1Abstract
Atypical lipomatous are rare tumors that typically arise out of soft tissues in the body and common in adults. Most lipomas comprise of mature fat cells that exhibit characteristic of benign tumor by nature. They are round, motile, non-painful slow growing masses, with a characteristic soft and soggy feel, usually appear in the hypodermic area of skin. Atypical lipomas, though uncommon and slow growing can be associated with syndromes such as multiple hereditary lipomatosis, colorless adipose, Gardner's syndrome and Madelung's disease. While surgery has been the primary treatment modality, doctors have managed few patients with radiation therapy (RT). Median age of diagnosis was found in the range: 36–76 years but intramuscular lipomas may occur irrespective of age group, right from childhood to old age. However, the occurrence dominancy was found between the ages of 42 and 72 years, with the average age at presentation reported as 47 to 57 years.
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Keywords:
Rare Tumor, Fat cells, Surgical removaL, Herbal therapy
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Published
2019-09-30
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1.
Dasvani, B, Khristi A, Thiyagarajan V. Review of Atypical Lipoma and its Natural Treatment. Scopus Indexed [Internet]. 2019 Sep. 30 [cited 2024 Nov. 19];12(5):4623-7. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/312
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Review Articles
References
Akbulut M, Aksoy A, and Bir F (2005). Intramuscular lipoma of the tongue: a case report and review of the literature. Aegean Pathol 2: 146-9.
Allen B, Rader C and Babigian A (2007). Giant lipomas of the upper extremity. Can J Plast Surg 15: 141-4.
Allen PW, Strungs I and MacCormac LB (1998). Atypical subcutaneous fatty tumors: a review of 37 referred cases. Pathology 30: 123-135.
Andac N, Baltacioglu F, Cimsit NC, Tuney D, and Aktan O (2003). Fat necrosis mimicking liposarcoma in a patient with pelvic lipomatosis: CT findings. Clin Imaging 27: 109-111.
Anderson SE, Schwab C, Stauffer E, Banic A and Steinbach LS. Hibernoma (2001). Imaging characteristics of a rare benign soft tissue tumor. Skeletal Radiol 30: 590-595.
Atilla S, Eilenberg SS and Brown JJ (1995). MRI appearance of a rare tumor. MagnReson Imaging 13: 335-337.
Balabram D, Cabral CCdSR, FilhoOdPR and Barros CPd (2014). Intramuscular lipoma of the subscapularis muscle. Sao Paulo Med J 132: 65-7.
Billing V, Mertens F, Domanski HA and Rydholm A (2008), Deep-seated ordinary and atypical lipomas: histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall. J Bone Joint Surg Br 90: 929-33.
Bjerreagaard P, Hagen K, Daugaard S and Kofoed H (1989). Intramuscular lipoma of the lower limb. Long-term follow-up after local resection. J Bone Joint Surg Br 71: 812-5.
Charles NC and Palu RN (2000). Intramuscular lipoma of the eyelid. Ophthalmic Surg Lasers 31: 340-1.
Chernev I (2014). Intramuscularlipoma: infiltrating vs. well-circumscribed variant. Pan Afr Med J 17: 170.
Colella G, Biondi P, Caltabiano R, et al (2009). Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J 2: 7906.
Collela G, Lanza A, Rossiello L and Rossiello R (2004). Infiltrating lipoma of the tongue. Oral Oncology Extra 40: 33-5.
Dionne GP and Seemayer TA (1974) Infiltrating lipomas and angiolipomas revisited. Cancer 33: 732-8.
Dutton J and Wright J (2006). Intramuscularlipoma of the superior oblique muscle. Orbit 25: 227-33.
Egea Martinez JM, Mena JF (2009). Lipoma of the supraspinatus muscle causing impingement syndrome a case report. J Shoulder Elbow Surg 18: 3-5.
Einarsdottir H, Soderlund V, Larson O, Jenner G and Bauer HC (1999). MR imaging of lipoma and liposarcoma. ActaRadiol 40: 64-68.
Einarsdottir H, Soderlund V, Larsson O, Mandahl N and Bauer HC (1999). Subfasciallipomatous tumors: MR and CT findings versus histopathological diagnosis and cytogenetic analysis. Acta Radiol 40: 603-609.
Evans H (1988). Liposarcomas and atypical lipomatous tumors: a study of 66 cases followed for a minimum of 10 years. SurgPathol 1: 41-54
Evans HL, Soule EH and Winkelmann RK (1979). Atypicallipoma, atypical intramuscular lipoma, and well-differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formerly classified as well-differentiated liposarcoma. Cancer 43: 574-584.
Fletcher CD and Martin-Bates E (1988). Intramuscular and intermuscular lipoma: neglected diagnoses. Histopathology 12: 275-87.
Forus A, Larramendy ML, Meza-Zepeda LA, et al (2001). Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases. Cancer Genet Cytogenet 125: 100-111.
Furlong MA, Fanburg-Smith JC and Miettinen M (2001). The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 25: 809-814.
Galant J, Marti-Bonmati L, Saez F, Soler R, Alcala-Santaella R and Navarro M (2003). The value of fat-suppressed T2 or STIR sequences in distinguishing lipoma from well-differentiated liposarcoma. EurRadiol 13: 337-343.
Geis JR, Russ PD and Adcock KA (1988). Computed tomography of a symptomatic infarcted thoracic lipoma. J ComputTomogr 12: 54-56.
Goldman AB, Di Carlo EF and Marcove RC (1993). Case report 774. Coincidental parosteallipoma with osseous excrescence and intramuscular lipoma. Skeletal Radiol 22: 138-45.
Greenberg SD, Isensee C, Gonzalez-Angulo A and Wallace SA (1963). Infiltrating lipomas of the thigh. Am J ClinPathol 39: 66-72.
Gutknecht DR (2004). Painful intramuscular lipoma of the thigh. South Med J 97: 1121-2.
Harrington AC, Adnot J and Chesser RS (1990). Infiltrating lipomas of the upper extremities. J DermatolSurgOncol 16: 834-7.
Hosono M, Kobayashi H, Fujimoto R, et al. (1997). Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation. Skeletal Radiol 26: 150-154.
Jelinek JS, Kransdorf MJ, Shmookler BM, Aboulafia AJ and Malawer MM. (1993). Liposarcoma of the extremities: MR and CT findings in the histologic subtypes. Radiology ; 186: 455-459.
Keskin G, Ustundag E and Ercin C (2002). Multiple infiltrating lipomas of the tongue. J Laryngol Otol1 16: 395-7.
Kindblom LG, Angervall L and Fassina AS (1982). Atypical lipoma. Acta Pathol Microbiol Immunol Scand 90: 27-36.
Kindblom LG, Angervall L, Stener B, et al (1974). Intermuscular and intramuscular lipomas and hibernomas: a clinical, roentgenologic, histologic, and prognostic study of 46 cases. Cancer 33: 754-62.
Kransdorf MJ, Bancroft LW, Peterson JJ, Murphey MD, Foster WC and Temple HT (2002). Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. Radiology 224: 99-104.
Kransdorf MJ, Moser RP, Jr, Meis JM and Meyer CA (1991). Fat-containing soft-tissue masses of the extremities. Radiographics 11: 81-106.
Lahrach K, Kadi K, Mezzani A, et al (2013). An unusual case of an intramuscular lipoma of the biceps brachii. Pan African Med J 15: 40.
Lakshmiah SR, Scott KW, Whear NM, Monoghan A (2000). Chondroidlipoma: a rare but diagnostically important lesion. Int J Oral MaxillofacSurg 29: 445-446.
Laliotis A, Bree E, Vasilaki S, et al (2013). Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: report of a case. Pol J Pathol 64: 224-7.
Laurino L, Furlanetto A, Orvieto E and Del Tos AP (2001). Well-differentiated liposarcoma (atypical lipomatous tumors). Arch Otolaryngol Head Neck Surg 18: 258-262
Lee JH, Do HD and Lee JC (2013). Well-circumscribed type of intramuscular lipoma in the chest wall. J Cardiothorac Surg 8: 181.
Lee Y, Jung J, Baek G and Chung M (2004). Intramuscular Lipoma in the Thenar or Hypothenar Muscles. Hand Surgery 9: 49-54.
Logan PM, Janzen DL, O'Connell JX, Munk PL and Connell DG (1996). Condroidlipoma: MRI appearances with clinical and histologic correlation. Skeletal Radiol 25: 592-595.
Lucas DR, Nascimento AG, Sanjay BK and Rock MG (1994). Well-differentiated liposarcoma: the Mayo Clinic experience with 58 cases. Am J ClinPathol 102: 677-683.
Matsumoto K, Hukuda S, Ishizawa M, Chano T and Okabe H. (1999). MRI findings in intramuscular lipomas. Skeletal Radiol 28: 145-152.
Matsumoto K, HukudaS, Ishizawa M, Chano T and Okabe H (1999). MRI findings in intramuscular lipomas. Skeletal Radiol 8: 145-52.
Matsumoto K, Hukuda S and Ishizawa M, et al (2000). Liposarcoma associated with multiple intramuscular lipomas. A case report. ClinOrthopRelat Res 373: 202-7.
Meis JM, Enzinger FM (1993). Chondroidlipoma: a unique tumor simulating liposarcoma and myxoidchondrosarcoma. Am J SurgPathol 17: 1103-1112.
Momin TA, Deyrup AT and Grist WJ, et al (2008). Laryngeal squamous cell carcinoma metastatic to a flank intramuscular lipoma. Am Surg 74: 447-8.
Murphey MD, Carroll JF and Flemming DJ, et al (2004). From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics 24: 1433-66.
Nishida J, Morita T and Ogose A, et al (2007). Imaging characteristics of deep-seated lipomatous tumors: intramuscular lipoma, intermuscularlipoma, and lipoma-like liposarcoma. J OrthopSci 12: 533-41.
Ohguri T, Aoki T and Hisaoka M, et al (2003). Differential diagnosis of benign peripheral lipoma from well-differentiated liposarcoma on MR imaging: is comparison of margins and internal characteristics useful? AJR 180: 1689-1694.
Oyama N, Oyama N and Hiroshi K, et al (2003). Left ventricular asynchrony caused by an intramuscular lipoma: computed tomographic and magnetic resonance detection. Circulation 107: e200-1.
Pant R, Poh ACC and Hwang SG (2005). An unusual case of an intramuscular breast mass. Ann Acad Med Singapore 34: 275-6.
Peer S, Kuhberger R, Dessl A, Judmaier W (1997). MR imaging findings in hibernoma. Skeletal Radiol 26: 507.
Ramos Pascua L, Alonso León A, Santos Sánchez JA and Ferrández Portal L (2001). Intramuscular lipoma of the deltoid mimicking a sarcoma. A case report. Chir Organi Mov 86: 153-7.
Regan JM, Bickel WH and Broders AC (1946). Infiltrating benign lipomas of the extremities. West J Surg 54: 87-93.
Rozental TD, Khoury LD, Donthineni-Rao R and Lackman RD (2002). Atypical lipomatous masses of the extremities: outcome of surgical treatment. ClinOrthop 398: 203-211.
Spano JP, Taillibert S, Khayat D and Terrier P. Hibernoma (2000). An uncommon tumor as a differential diagnosis of liposarcoma of the thigh. Anticancer Res 20: 4803-4804.
Stewart MG, Schwartz MR and Alford BR (1994). Atypical and malignant lipomatous lesions of the head and neck. Arch Otolaryngol Head Neck Surg 120: 1151-1155.
Warner JJ, Madsen N and Gerber C (1990). Intramuscular lipoma of the deltoid causing shoulder pain: report of two cases. ClinOrthop 253: 110-2.
Yang YJ, Damron TA, Cohen H and Hojnowski L (2001). Distinction of well-differentiated liposarcoma from lipoma in two patients with multiple well-differentiated fatty masses. Skeletal Radiol 30: 584-589.
Allen B, Rader C and Babigian A (2007). Giant lipomas of the upper extremity. Can J Plast Surg 15: 141-4.
Allen PW, Strungs I and MacCormac LB (1998). Atypical subcutaneous fatty tumors: a review of 37 referred cases. Pathology 30: 123-135.
Andac N, Baltacioglu F, Cimsit NC, Tuney D, and Aktan O (2003). Fat necrosis mimicking liposarcoma in a patient with pelvic lipomatosis: CT findings. Clin Imaging 27: 109-111.
Anderson SE, Schwab C, Stauffer E, Banic A and Steinbach LS. Hibernoma (2001). Imaging characteristics of a rare benign soft tissue tumor. Skeletal Radiol 30: 590-595.
Atilla S, Eilenberg SS and Brown JJ (1995). MRI appearance of a rare tumor. MagnReson Imaging 13: 335-337.
Balabram D, Cabral CCdSR, FilhoOdPR and Barros CPd (2014). Intramuscular lipoma of the subscapularis muscle. Sao Paulo Med J 132: 65-7.
Billing V, Mertens F, Domanski HA and Rydholm A (2008), Deep-seated ordinary and atypical lipomas: histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall. J Bone Joint Surg Br 90: 929-33.
Bjerreagaard P, Hagen K, Daugaard S and Kofoed H (1989). Intramuscular lipoma of the lower limb. Long-term follow-up after local resection. J Bone Joint Surg Br 71: 812-5.
Charles NC and Palu RN (2000). Intramuscular lipoma of the eyelid. Ophthalmic Surg Lasers 31: 340-1.
Chernev I (2014). Intramuscularlipoma: infiltrating vs. well-circumscribed variant. Pan Afr Med J 17: 170.
Colella G, Biondi P, Caltabiano R, et al (2009). Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J 2: 7906.
Collela G, Lanza A, Rossiello L and Rossiello R (2004). Infiltrating lipoma of the tongue. Oral Oncology Extra 40: 33-5.
Dionne GP and Seemayer TA (1974) Infiltrating lipomas and angiolipomas revisited. Cancer 33: 732-8.
Dutton J and Wright J (2006). Intramuscularlipoma of the superior oblique muscle. Orbit 25: 227-33.
Egea Martinez JM, Mena JF (2009). Lipoma of the supraspinatus muscle causing impingement syndrome a case report. J Shoulder Elbow Surg 18: 3-5.
Einarsdottir H, Soderlund V, Larson O, Jenner G and Bauer HC (1999). MR imaging of lipoma and liposarcoma. ActaRadiol 40: 64-68.
Einarsdottir H, Soderlund V, Larsson O, Mandahl N and Bauer HC (1999). Subfasciallipomatous tumors: MR and CT findings versus histopathological diagnosis and cytogenetic analysis. Acta Radiol 40: 603-609.
Evans H (1988). Liposarcomas and atypical lipomatous tumors: a study of 66 cases followed for a minimum of 10 years. SurgPathol 1: 41-54
Evans HL, Soule EH and Winkelmann RK (1979). Atypicallipoma, atypical intramuscular lipoma, and well-differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formerly classified as well-differentiated liposarcoma. Cancer 43: 574-584.
Fletcher CD and Martin-Bates E (1988). Intramuscular and intermuscular lipoma: neglected diagnoses. Histopathology 12: 275-87.
Forus A, Larramendy ML, Meza-Zepeda LA, et al (2001). Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases. Cancer Genet Cytogenet 125: 100-111.
Furlong MA, Fanburg-Smith JC and Miettinen M (2001). The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 25: 809-814.
Galant J, Marti-Bonmati L, Saez F, Soler R, Alcala-Santaella R and Navarro M (2003). The value of fat-suppressed T2 or STIR sequences in distinguishing lipoma from well-differentiated liposarcoma. EurRadiol 13: 337-343.
Geis JR, Russ PD and Adcock KA (1988). Computed tomography of a symptomatic infarcted thoracic lipoma. J ComputTomogr 12: 54-56.
Goldman AB, Di Carlo EF and Marcove RC (1993). Case report 774. Coincidental parosteallipoma with osseous excrescence and intramuscular lipoma. Skeletal Radiol 22: 138-45.
Greenberg SD, Isensee C, Gonzalez-Angulo A and Wallace SA (1963). Infiltrating lipomas of the thigh. Am J ClinPathol 39: 66-72.
Gutknecht DR (2004). Painful intramuscular lipoma of the thigh. South Med J 97: 1121-2.
Harrington AC, Adnot J and Chesser RS (1990). Infiltrating lipomas of the upper extremities. J DermatolSurgOncol 16: 834-7.
Hosono M, Kobayashi H, Fujimoto R, et al. (1997). Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation. Skeletal Radiol 26: 150-154.
Jelinek JS, Kransdorf MJ, Shmookler BM, Aboulafia AJ and Malawer MM. (1993). Liposarcoma of the extremities: MR and CT findings in the histologic subtypes. Radiology ; 186: 455-459.
Keskin G, Ustundag E and Ercin C (2002). Multiple infiltrating lipomas of the tongue. J Laryngol Otol1 16: 395-7.
Kindblom LG, Angervall L and Fassina AS (1982). Atypical lipoma. Acta Pathol Microbiol Immunol Scand 90: 27-36.
Kindblom LG, Angervall L, Stener B, et al (1974). Intermuscular and intramuscular lipomas and hibernomas: a clinical, roentgenologic, histologic, and prognostic study of 46 cases. Cancer 33: 754-62.
Kransdorf MJ, Bancroft LW, Peterson JJ, Murphey MD, Foster WC and Temple HT (2002). Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. Radiology 224: 99-104.
Kransdorf MJ, Moser RP, Jr, Meis JM and Meyer CA (1991). Fat-containing soft-tissue masses of the extremities. Radiographics 11: 81-106.
Lahrach K, Kadi K, Mezzani A, et al (2013). An unusual case of an intramuscular lipoma of the biceps brachii. Pan African Med J 15: 40.
Lakshmiah SR, Scott KW, Whear NM, Monoghan A (2000). Chondroidlipoma: a rare but diagnostically important lesion. Int J Oral MaxillofacSurg 29: 445-446.
Laliotis A, Bree E, Vasilaki S, et al (2013). Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: report of a case. Pol J Pathol 64: 224-7.
Laurino L, Furlanetto A, Orvieto E and Del Tos AP (2001). Well-differentiated liposarcoma (atypical lipomatous tumors). Arch Otolaryngol Head Neck Surg 18: 258-262
Lee JH, Do HD and Lee JC (2013). Well-circumscribed type of intramuscular lipoma in the chest wall. J Cardiothorac Surg 8: 181.
Lee Y, Jung J, Baek G and Chung M (2004). Intramuscular Lipoma in the Thenar or Hypothenar Muscles. Hand Surgery 9: 49-54.
Logan PM, Janzen DL, O'Connell JX, Munk PL and Connell DG (1996). Condroidlipoma: MRI appearances with clinical and histologic correlation. Skeletal Radiol 25: 592-595.
Lucas DR, Nascimento AG, Sanjay BK and Rock MG (1994). Well-differentiated liposarcoma: the Mayo Clinic experience with 58 cases. Am J ClinPathol 102: 677-683.
Matsumoto K, Hukuda S, Ishizawa M, Chano T and Okabe H. (1999). MRI findings in intramuscular lipomas. Skeletal Radiol 28: 145-152.
Matsumoto K, HukudaS, Ishizawa M, Chano T and Okabe H (1999). MRI findings in intramuscular lipomas. Skeletal Radiol 8: 145-52.
Matsumoto K, Hukuda S and Ishizawa M, et al (2000). Liposarcoma associated with multiple intramuscular lipomas. A case report. ClinOrthopRelat Res 373: 202-7.
Meis JM, Enzinger FM (1993). Chondroidlipoma: a unique tumor simulating liposarcoma and myxoidchondrosarcoma. Am J SurgPathol 17: 1103-1112.
Momin TA, Deyrup AT and Grist WJ, et al (2008). Laryngeal squamous cell carcinoma metastatic to a flank intramuscular lipoma. Am Surg 74: 447-8.
Murphey MD, Carroll JF and Flemming DJ, et al (2004). From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics 24: 1433-66.
Nishida J, Morita T and Ogose A, et al (2007). Imaging characteristics of deep-seated lipomatous tumors: intramuscular lipoma, intermuscularlipoma, and lipoma-like liposarcoma. J OrthopSci 12: 533-41.
Ohguri T, Aoki T and Hisaoka M, et al (2003). Differential diagnosis of benign peripheral lipoma from well-differentiated liposarcoma on MR imaging: is comparison of margins and internal characteristics useful? AJR 180: 1689-1694.
Oyama N, Oyama N and Hiroshi K, et al (2003). Left ventricular asynchrony caused by an intramuscular lipoma: computed tomographic and magnetic resonance detection. Circulation 107: e200-1.
Pant R, Poh ACC and Hwang SG (2005). An unusual case of an intramuscular breast mass. Ann Acad Med Singapore 34: 275-6.
Peer S, Kuhberger R, Dessl A, Judmaier W (1997). MR imaging findings in hibernoma. Skeletal Radiol 26: 507.
Ramos Pascua L, Alonso León A, Santos Sánchez JA and Ferrández Portal L (2001). Intramuscular lipoma of the deltoid mimicking a sarcoma. A case report. Chir Organi Mov 86: 153-7.
Regan JM, Bickel WH and Broders AC (1946). Infiltrating benign lipomas of the extremities. West J Surg 54: 87-93.
Rozental TD, Khoury LD, Donthineni-Rao R and Lackman RD (2002). Atypical lipomatous masses of the extremities: outcome of surgical treatment. ClinOrthop 398: 203-211.
Spano JP, Taillibert S, Khayat D and Terrier P. Hibernoma (2000). An uncommon tumor as a differential diagnosis of liposarcoma of the thigh. Anticancer Res 20: 4803-4804.
Stewart MG, Schwartz MR and Alford BR (1994). Atypical and malignant lipomatous lesions of the head and neck. Arch Otolaryngol Head Neck Surg 120: 1151-1155.
Warner JJ, Madsen N and Gerber C (1990). Intramuscular lipoma of the deltoid causing shoulder pain: report of two cases. ClinOrthop 253: 110-2.
Yang YJ, Damron TA, Cohen H and Hojnowski L (2001). Distinction of well-differentiated liposarcoma from lipoma in two patients with multiple well-differentiated fatty masses. Skeletal Radiol 30: 584-589.
