Development of nanoparticles for the Novel anticancer therapeutic agents for Acute Myeloid Leukemia
Development of nanoparticles for the Novel anticancer therapeutic agents for AML
DOI:
https://doi.org/10.37285/ijpsn.2023.16.4.7Abstract
Acute myeloid leukaemia is becoming more predominant in blood cancer in geriatrics people groups. In 2017, four new therapeutic candidates have been approved by the FDA: Enasidenib, CPX 351, Midostaurin, and Gemtuzumab ozogamicin; with the approval of Venetoclax and Daurismo, additional advances were achieved in 2018. Ivosidenib and gilteritinib were also accepted as single-agent therapy in persistent and recurrent AML 2018. Most of the anticancer drugs belong to Biopharmaceutical classification system-II (BSC), and BCS class-IV has poor bioavailability because of solubility issues. We will overcome this problem by preparing nanoparticles of this drug by using different nanoparticle preparation methods.
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Acute myeloid leukemia, Nanoparticle, Anticancer therapeutic agents, FLT3 inhibitors, Ionic gelation, emulsion-Solvent evaporation, Double Emulsion
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