Effect of Polymeric Compositions on Pharmacotechnical Properties of Carvedilol Transdermal Film

DOI:

https://doi.org/10.37285/ijpsn.2009.2.1.10

Authors

  • Umesh D. Shivhare
  • Vikrant P. Dorlikar
  • Kishore P. Bhusari
  • Vijay B. Mathur
  • Bhiku N. Mirani

Abstract

Transdermal films of carvedilol were prepared by using Eudragit RL100  (ERL100) either alone or in combination with Eudragit RS100 (ERS100), hydroxypropyl methylcellulose K 15 LV (HPMC), and ethyl cellulose (EC). The drug release was extended over a period of 24 h from all formulations. The formulation A5 showed 98.33 cumulative % drug releases in 24 h and followed zero order kinetics. The drug transport mechanism was observed to be Fickian. The cumulative % drug diffused through artificial permeation membrane (cellophane A 393) from same formulation was 100.52 % over a 12 h. The mechanism of dug release was governed by Peppas model and the drug diffusion rate followed zero order kinetics. The formulation A5 comprising of polymers ERL 100, ERS 100, EC and   HPMC in 7:1:1:1 ratio fulfills the requirement of good TDDS.

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Keywords:

transdermal film, carvedilol, in vitro permeation, WVTR, SEM

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Published

2009-05-31

How to Cite

1.
D. Shivhare U, P. Dorlikar V, P. Bhusari K, B. Mathur V, N. Mirani B. Effect of Polymeric Compositions on Pharmacotechnical Properties of Carvedilol Transdermal Film. Scopus Indexed [Internet]. 2009 May 31 [cited 2024 Dec. 23];2(1):457-64. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/323

Issue

Vol. 2 No. 1 (2009): April-June 2009

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Arora, P, and Mukherjee, B. (2002) Design, development, physicochemical, in- vitro and in-vivo evaluation of transdermal patches containing diclofenac diethyl ammonium salt. J Pharm Sci., 91(9): 2076–89.

Bhalla, H L, and Gadkari, S J. (1986) Transdermal films of isosorbide dinitrate. Indian Drugs, 24(6): 313-15.

Chandrashekar, N S, and Shobha Rani R H. (2005) Design, fabrication and calibration of modified diffusion cell for transdermal diffusion studies. Int J Pharma Excip, 105.

Costa, P, and Lobo, J S. (2001) Modeling and comparison of dissolution profiles. European J. of Pharma Sci., 13: 123-33.

Dehgan, G R, Hassan, M, Parakh S R, and Deshpande, S G. (1993) Studies on polymeric systems for transdermal drug delivery. Indian Drugs, 30(12): 616-21.

Devi, K V, Saisivam, S, Maria, G R, Deepti, P U.(2003) Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Development and Industrial Pharmacy 29(5): 495–03.