A Systematic Study on Flowability and Compressibility of Asparagus racemosus root Powder for Tablet Preparation
DOI:
https://doi.org/10.37285/ijpsn.2008.1.2.3Abstract
The dried root of Asparagus racemosus is widely used as mild antihypertensive and tranquilizer. The objective of the present research was to study the original flowability, compressibility and compactibility of Asparagus racemosus root powder and develop its tablet formulations by wet granulation and direct compression technology. The consolidation behavior of drug and tablet formulations were studied by using Heckel and Leuenberger equation. Asparagus racemosus root powder showed very poor flowability and compactibility. Kawakita analysis revealed improved flowability for formulations prepared by direct compression and wet granulation technique. The Heckel plot showed that Asparagus racemosus powder is soft in nature and poor in die filling. Granules showed higher degree of plasticity and fragmentation than powder and direct compression formulations. The compression susceptibility parameter for compact formed by direct compression and wet granulation technique indicated that the maximum crushing strength is reached faster at lower pressures of compression as opposed to Asparagus racemosus powder. From this study, it is concluded that desired flowability, compressibility and compactibility of Asparagus racemosus root powder can be obtained by direct compression and wet granulation technique
Downloads
Metrics
Keywords:
Asparagus racemosus, flowability, compressibility, tablets
Downloads
Published
How to Cite
Issue
Section
References
Bhattacharya SK, Bhattacharya A, and Chakrabarti A. Adaptogenic activity of siotone a polyherbal formulation of Ayurvedic rasayanas. Indian J.Exp. Biol. 38: 119-128 (2000).
Carson JW, and Marinelli J. Characterize bulk solids to ensure smooth flow. Chem Eng. 4: 78 - 98 (1994).
Chopra RN, Chopra IC, Handa KL and Kapur LD. Indigenous drugs of India, Academic Publishers, Calcutta, 1994.
Dalvi SS, Nadkarni PM, and Gupta KC. Effect of Asparagus racemosus (Shatavari) on gastric emptying time in normal healthy volunteers. J.Postgrad.Med. 36: 91-94 (1990).
Esezobo S, and Pilpel N. Some formulation factors affecting the tensile strength, disintegration and dissolution of uncoated oxytetracycline tablets. J Pharm. Pharmacol. 28: 8-16 (1976).
Fohrer C. Interparticulate attraction mechanisms. In Alderborn G and Nystrom C (eds.), Pharmaceutical Powder Compaction Technology, Marcel Dekker Inc, New York, 1996, pp. 1-15
Heckel RW. Density-pressure relationships in powder compaction. Trans Met. 221: 671-675 (1961).
Ilkka J, and Paronen P. Prediction of the compression behavior of powder mixtures by the Heckel equation. Int J Pharm. 94: 181-187 (1993).
Itiola OA. Compressional characteristics of three starches and the mechanical properties of their tablets. Pharm World J. 8: 91-94 (1991).
Jetzer W, Leuenberger H, and Sucker H. The compressibility and compactibility of pharmaceutical powders. Pharm. Technol. 7: 33-39 (1983).
Karsten H, and Katharina MP. Evaluation of a new coprocessed compound based on lactose and maize tarch for tablet formulation. AAPS PharmaSciTech. 6: Article 16 (2004).
Kawakita K, and Ludde KH. Some considerations on powder compression equations. Powder Technology. 4: 61-68 (1970/71).
Korhonen O, Pohja S, Peltonen S, Suihko E, Vidgren M, Paronen P, and Ketolainen J. Effect of physical properties for starch acetate powders on tableting. AAPS PharmSciTech. 3: Article 34 (2002).
Leuenberger H, and Rohera DB. Fundamentals of powder compression. 1. The compactibility and compressibility of Pharmaceutical powders. Pharm. Res. 3: 12-22 (1986).
Oketch-Rabah HA. Phytochemical constituents of the genus asparagus and their biological activities. Hamdard. 41: 33-43 (1998).
Paronen P and Iilla J. Porosity-pressure function. In Alderborn G and Nystrom C (eds.), Pharmaceutical Powder Compaction Technology, Marcel Dekker Inc, New York, 1996, pp. 55-75.
Pesonen T, and Paronen P. Evaluation of new cellulose material as a binding agent for the direct compression of tablets. Drug Dev. Ind. Pharm. 12: 2091-2111 (1986).
Rege NN, Thatte UM, and Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic Medicine. Phytother Res. 13: 275- 291 (1999).
Shileout G, Armold K, and Muller G. Powder and mechanical properties of microcrystalline cellulose with different degrees of polymerization. AAPS PharmSciTech. 3: Article 11 (2000).
Yamashiro M, Yuasa Y, and Kawakita K. An experimental study on the relationships between compressibility, fluidity and cohesion of powder solids at small tapping numbers. Powder Technology. 34: 225-231 (1983).
