A Review on Phytochemical, Biological, and Pharma-cological Effects of Psidium guajava Linn. (Guava)

DOI:

https://doi.org/10.37285/ijpsn.2024.17.1.7

Authors

  • Haritha devi vanjarapu Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur
  • Subhashini Dukkipati Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur
  • Vijayapandi Pandy School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University

Abstract

In today’s time there is a tremendously increased use of herbal products worldwide. Psidium guajava L., commonly known as guava, is an essential tropical food plant with various medicinal properties. It is widely available in many countries, especially in Asian countries it is used as a treatment for many diseases. Each plant part has particular properties to treat diseases. The bioactive constituents extracted from Psidium guajava (P. guajava) include (gallic acid, catechin, rutin, Gallocatechin, vanillic acid, quercetin, p-hydroxybenzoic acid, isoquercitrin, casuarina, pedunculagin dimer isomer, myricetin, morin, luteolin, apigenin, ellagic acid, guanosine B, Quercetin-3-0-β-glucoside, ursolic acid and also essential oils) used for the treatment of diseases like anti-diabetes, anti- hypertension, anti- hyperlipidaemia, anti-cancer, autonomous, neuroprotective, anti-depressant, etc. The goal of this review is to provide up-to-date information on the ethnomedicinal uses, bioactive compounds and pharmacological activity of Psidium guajava with greatest emphasis on its therapeutic potential. 

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

P. guajava, neuroprotective, quercetin, Gallocatechin, anti-depressant, guavinoside

Published

2024-02-01

How to Cite

1.
vanjarapu H devi, Dukkipati S, Pandy V. A Review on Phytochemical, Biological, and Pharma-cological Effects of Psidium guajava Linn. (Guava) . Scopus Indexed [Internet]. 2024 Feb. 1 [cited 2024 Dec. 21];17(1):7173-82. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/3447

Issue

Section

Review Articles

References

Arjun kafle, Sushree SM, et.al, A review on medicinal properties of Psidium guajava Journal of Medicinal Plants Studies 2018; 6(4) 44-47.

Eziuche AU, Okezie E et al, The ethnobotanical, phytochemistry and pharmacological activity of Psidium guajava Arabian Journal of Chemistry 2022; 15, 103759.

Sumra Nasser, Shabbir H et.al, The phytochemistry and medicinal value of Psidium guajava (guava) Clinical Phyto science 2018; 4:32.

Sonchita B, Debashish M et.al, Evaluation of neurobehavioral activities of ethanolic extract of Psidium guajava Linn leaves in mice model future journal of pharmaceutical sciences 2021 7:36.

Rose Martha et.al, Psidium guajava: A review of its traditional uses, phytochemistry, and pharmacology Journal of Ethnopharmacology 2008 volume 117 issue I.

Elixabet diaz-de-cerio et.al, Health effects of Psidium guajava L. leaves an overview of the last decade International Journal of Molecular Sciences 2017 18,897.

Shirur Dakappa S et.al, A review on the medicinal plant Psidium guajava linn (MYRTACEAE) Journal of drug delivery and therapeutics 2013 3(2),162-168.

Manoj K et.al, Guava (Psidium guajava) Leaves Nutritional composition, phytochemical profile and health-promoting bioactivities Food 2021 10,752.

Girish Kumar G et al, Psidium guajava Linn current research and future prospects Journal of Pharmacy Research 2011 4(1), 42-46.

Alves, C.T., Ferreira, I.C., Barros, L., Silva, S., Azeredo, J., Henriques, M., Antifungal activity of phenolic compounds identified in flowers from North Eastern Portugal against Candida species. Future Microbial. 2014, 9 (2), 139–146. https://doi.org/10.2217/ fmb.13.147.

Ma, Z., Huang, W., Feng X., Yang F., Li, D., separation. identification and antioxidant activity of polyphenols from lotus seed Epicarp. Molecules 2019, 24 (4007),1-10.

Dong, H., Chen, S.X., Kini, R.M., Xu, H.X., Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J. Nat. Prod.1998, 61 (11), 1356–1360.

Molonia, M.S., Occhiuto, C., Muscara`, C., Speciale, A., Bashllari, R., Villarroya, F., Saija, A., Cimino, F., Cristani, M. Cyanidin3-O-glucoside restores insulin signaling and reduces inflammation in hypertrophic adipocytes. Arch. Biochem. Biophys. 2020, 691, https:// doi.org/10.1016/j.abb.2020.108488 108488.

Jiang, A., Zhang, Y., Zhang, X., Wu, D., Liu, Z., Li, S., Liu, X., Han, Z., Wang, C., Wang, J., Wei, Z., Guo, C., Yang, Z. Morin alleviates LPS-induced mastitis by inhibiting the PI3K/AKT, MAPK, NF-jB, and NLRP3 signalling pathway and protecting the integrity of the blood-milk barrier. Int. Immunopharmacology. 2020, 78, https://doi.org/10.1016/j.intimp.2019.105972 105972.

Eidenberger, T., Selg, M., Krennhuber, K. Inhibition of dipeptidyl peptidase activity by flavonol glycosides of guava (Psidium guajava L.): A key to the beneficial effects of guava in type II diabetes mellitus. Fitoterapia 2013, 89 (1), 74–79. https://doi.org/ 10.1016/j.fitote.2013.05.015.

Sohail, A., Bhat, W.F., Bhat, S.A., Furkan, M., Shah, A., Bano, B.,. Investigating the preventive effects of baicalin and Gallo catechin against glyoxal-induced cystatin aggregation. J. Biomol. Struct. Dyn.2018, 36 (14), 3791–3802. https://doi.org/10.1080/ 07391102.2017.1400470.

Cianfaglione, K., Blomme, E.E., Quassinti, L., Bramucci, M., Lupidi, G., Dall’Acqua, S., Maggi, F., Cytotoxic essential oils from Eryngium campestre and Eryngium Amethystium (Apiaceae) growing in central Italy. Chem Biodivers. 2017, 14 (7). https://doi.org/ 10.1002/cbdv.201700096.

Budzynska, B., Faggio, C., Kruk-Slomka, M., Samec, D., Nabavi, S. F., Sureda, A., Devi, K.P., Nabavi, S.M., Rutin as a neuroprotective agent: from bench to bedside. Curr. Med. Chem. 2019 26 (27), 5152–5164. https://doi.org/10.2174/ 0929867324666171003114154.

Imran, M., Aslam, Gondal, T., Atif, M., Shahbaz, M., Batool, Qaisarani, T., Hanif, Mughal, M., Salehi, B., Martorell, M., Sharifi-Rad, J. Apigenin as an anticancer agent. Phytother. Res. 2020, 34(8), 1812-1828. Doi: 10.1002/ptr.6647.

Ukwueze, S.E., Osadebe, P.O., Okoye, F.B., . A new antibacterial benzophenone glycoside from Psidium guajava (Linn.) leaves. Nat. Prod Res. 2015, 29 (18), 1728–1734. https://doi.org/10.1080/ 14786419.2014.1003188.

Li, Y., Xu, J., Li, D., Ma, H., Mu, Y., Huang, X., Li, L., Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury by regulating the Nrf2 and JNK signaling pathways. Food Funct. 2020, 11 (9), 8297–8308. https://doi.org/10.1039/ d0fo01338b.

Magalingam, K.B., Radhakrishnan, A., Haleagrahara, N., Protective effects of quercetin glycosides, rutin, and iso quercitrin against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rat pheochromocytoma (PC-12) cells. Int. J. Immunopathology Pharmacal. 2016, 29 (1), 30–39.

Wang, L., Wu, H., Yang, F., Dong, W., The Protective Effects of Myricetin against Cardiovascular Disease. J. Nutr. Sci. Vitaminol. 2019, 65 (6), 470–476.

Suganya T et.al, Antioxidant active principles isolated from Psidium guajava grown in Thailand Scientia pharmaceutical (sci. pharm) 2007 75,179-193.

Vajina p bulugahapitiya et.al, phytochemistry and medicinal properties of Psidium guajava L. Leave A review plant science today 2021 vol 8 (4):963-971.

Safaa I Khedr et al., Psidium guajava Linn leaf ethanolic extract: In vivo germicidal potential with ultrastructural damage, anti-inflammatory and antioxidant effects Saudi Journal of Biological Sciences 28, 2021,427-439.

Mi Jang et.al, Anti-inflammatory effects of an ethanolic extract of guava (Psidium guajava L) leaves invitro and in vivo Journal of medicinal food vol.17, No.6.

Daiane Cristina de Assis B et.al, effects of Psidium guajava L, leaves extract on blood pressure control and IL-10 production in salt–dependent hypertensive rats’ biomedicine and pharmacotherapy 155,2022,113796.

Kavita V et.al, the effect of guava leaves on hyperlipidaemia patients the Pharma Innovation Journal 2019:8(6):803-806.

Chanchal K Roy et.al, Hepatoprotective activity of Psidium guajava Linn leaf extract India journal of experimental biology vol.44 April 2006 pp.- 305-311.

Chamakuri subba roa Comparative study of tannin fraction from Psidium guajava Linn. Leaves and bark for wound healing activity Research and review: journal of Pharmacognosy and Phytochemistry 2015 volume-3, issue-4.

Chaitra S. R, Roopa P. Nayak, Uttara Krishna Evaluation of antidepressant effect of aqueous extract of Psidium guajava leaves on Wistar albino rats International Journal of Basic & Clinical Pharmacology 2019, Vol 8, Issue 2.