Development of Effervescent Tablets of Alendronate Sodium with Improved Intestinal Permeation

Alendronate sodium

DOI:

https://doi.org/10.37285/ijpsn.2018.11.1.7

Authors

  • Prasad Vure
  • Sundeep Chaurasia

Abstract

The aim of the present study is to develop effervescent tablets of alendronate sodium to improve their intestinal permeability to treat osteoporosis. Effervescent tablets of alendronate sodium were developed with different ratios of acid to alkaline components having a pH of about 3 to about 6.5. The tablets were prepared by direct compression method. The physical mixture blend was evaluated for angle of repose, true density, bulk density, compressibility index. The formulated tablets were subjected to thickness, weight variation, hardness, friability, drug content and pH. The in vitro dissolution studies were carried out using the USP Type 2 apparatus. Formulation F14 was considered as optimized formulation because it shows drug release pattern higher than that of the other formulations and conventional marketed formulation. Ex vivo permeation studies were performed for the optimized formulation (F14) and that of the conventional marketed formulation. The drug release of the formulation (F14) was higher than the marketed formulation. Accelerated stability studies of the optimized formulation indicated that there were no signs of visually distinguishable changes, drug content and in vitro dispersion time. Thus, an increase in drug release may enhance absorption, in turn may enhance bioavailability.       



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Keywords:

Effervescent tablet, Alendronate sodium, Dissolution study, Intestinal permeability

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Published

2018-01-31

How to Cite

1.
Vure P, Chaurasia S. Development of Effervescent Tablets of Alendronate Sodium with Improved Intestinal Permeation: Alendronate sodium. Scopus Indexed [Internet]. 2018 Jan. 31 [cited 2024 Nov. 19];11(1):3990-7. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/354

Issue

Vol. 11 No. 1 (2018): January-February 2018

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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