Development and In Vitro – In Vivo Evaluation of Gastro-retentive Floating Tablets Containing Repaglinide

DOI:

https://doi.org/10.37285/ijpsn.2018.11.2.4

Authors

  • Poornima P
  • Abbulu K
  • Mukkanti K

Abstract

The present investigation concerns the development of the repaglinide floating matrix tablets, which after oral administration are designed to prolong the gastric residence time, increase the drug bioavailability and diminish the side effects of irritating drugs. FTIR studies revealed that there is no interaction between the drug and polymers used for the formulation. Among all the formulations F21 containing HPMC K1500 PH PRM, Polyox WSR-303 and Sodium bicarbonate, as gas generating agent was selected as optimized formulation based on physico chemical properties, floating lag time (36 sec) and total floating time (>24 h). From in vitro dissolution studies, the optimized formulation F21 showed drug release of 98.92±5.19% within 24h whereas 95.09±5.01% of the drug was released from the marketed product within 1h. The major mechanism of drug release follows zero order kinetics and non-Fickian transport by coupled diffusion and erosion. In vivo experiments supported the expectations in prolonging the gastric residence time in the fasted state in beagle dogs. The mean gastric residence time for the tested tablets was 270 min±60. This result is encouraging, because a longer gastric residence time is an important condition for higher bioavailability of the drugs included in the prolonged or controlled release dosage forms.

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Keywords:

Repaglinide, Floating tablets, Drug delivery., HPMC K1500 PH PRM

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Published

2018-03-31

How to Cite

1.
P P, K A, K M. Development and In Vitro – In Vivo Evaluation of Gastro-retentive Floating Tablets Containing Repaglinide. Scopus Indexed [Internet]. 2018 Mar. 31 [cited 2024 Dec. 22];11(2):4026-3. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/360

Issue

Vol. 11 No. 2 (2018): March-April 2018

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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