Solubility Enhancement of Poorly Water-Soluble Antifungal Drug Acyclovir by Nanocrystal Formulation Approach

DOI:

https://doi.org/10.37285/ijpsn.2018.11.2.5

Authors

  • Prakash Goudanavar
  • Ankit Acharya
  • Vinay C.H

Abstract

Administration of an antiviral drug, acyclovir via the oral route leads to low and variable bioavailability (15-30%). Therefore, this research work was aimed to enhance bioavailability of acyclovir by nanocrystallization technique. The drug nanocrystals were prepared by anti-solvent precipitation method in which different stabilizers were used. The formed nanocrystals are subjected to biopharmaceutical characterization including solubility, particle size and in-vitro release. SEM studies showed nano-crystals were crystalline nature with sharp peaks. The formulated drug nanocrystals were found to be in the range of 600-900nm and formulations NC7 and NC8 showed marked improvement in dissolution velocity when compared to pure drug, thus providing greater bioavailability. FT-IR and DSC studies revealed the absence of any chemical interaction between drug and polymers used. 

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Keywords:

Acyclovir, nanocrystals, in-vitro release, nanocrystallization technique

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Published

2018-03-31

How to Cite

1.
Goudanavar P, Acharya A, C.H V. Solubility Enhancement of Poorly Water-Soluble Antifungal Drug Acyclovir by Nanocrystal Formulation Approach. Scopus Indexed [Internet]. 2018 Mar. 31 [cited 2024 Nov. 19];11(2):4036-42. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/361

Issue

Vol. 11 No. 2 (2018): March-April 2018

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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