Solubility Enhancement of Poorly Water-Soluble Antifungal Drug Acyclovir by Nanocrystal Formulation Approach

DOI:

https://doi.org/10.37285/ijpsn.2018.11.2.5

Authors

  • Prakash Goudanavar
  • Ankit Acharya
  • Vinay C.H

Abstract

Administration of an antiviral drug, acyclovir via the oral route leads to low and variable bioavailability (15-30%). Therefore, this research work was aimed to enhance bioavailability of acyclovir by nanocrystallization technique. The drug nanocrystals were prepared by anti-solvent precipitation method in which different stabilizers were used. The formed nanocrystals are subjected to biopharmaceutical characterization including solubility, particle size and in-vitro release. SEM studies showed nano-crystals were crystalline nature with sharp peaks. The formulated drug nanocrystals were found to be in the range of 600-900nm and formulations NC7 and NC8 showed marked improvement in dissolution velocity when compared to pure drug, thus providing greater bioavailability. FT-IR and DSC studies revealed the absence of any chemical interaction between drug and polymers used. 

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

Acyclovir, nanocrystals, in-vitro release, nanocrystallization technique

Downloads

Published

2018-03-31

How to Cite

1.
Goudanavar P, Acharya A, C.H V. Solubility Enhancement of Poorly Water-Soluble Antifungal Drug Acyclovir by Nanocrystal Formulation Approach. Scopus Indexed [Internet]. 2018 Mar. 31 [cited 2024 Dec. 22];11(2):4036-42. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/361

Issue

Vol. 11 No. 2 (2018): March-April 2018

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Eerdenbrugh BV, Mooter GV, and Augustijns P (2008). Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products. Int J Pharm 364: 64-75.
Gao L, Zhang D, and Chen M (2008). Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res 10: 845-862.
Hecq J, Deleers M, Fanara D, Vranckx H, and Amighi K (2005). Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. Int J Pharm 299: 167-177.
Katteboinaa S, Chandrasekhar VSR, and Balaji S (2010). Drug nanocrystals: A novel formulation approach for poorly soluble drugs. Int J Pharm Tech Res 3: 682-694.
Loftsson T (2002). Cyclodextrins and the biopharmaceutics classification system of drugs. J Inclu Pheno Macrocyc Chem 44: 63-67.
Naresh KN, Deepika P, Srilatha M, Adukondalu D , Sriram P, and Reddy MV (2015). Formulation and evaluation of acyclovir orodispersible tablets using sublimation method. J General Pract 3: 208-212.
Nerurkar J, Jun HW, Prince JC, and Park MO (2005). Controlled release matrix tablets of ibuprofen using cellulose ethers and carrageenans: effect of formulation factors on dissolution rate. Eur J Pharm Biopharm 61: 56-68.
Peng Q, Dengning X, Hongze P, Hongyu P, Yinnong J, and Fude C (2011). Nitrendipine nanocrystals: its preparation, chara-cterization and in-vitro in-vivo evaluation. AAPS Pharm Sci Tech 12(4): 212-218.
Roghieh (2005). Nanotechnology approaches to solving the problems of poorly soluble drugs. Drug Deli World Summer 57: 273-285.
Samyuktha RB, Vedha HB, Reddy B, and Parimaladevi PS (2010). The recent developments on gastric floating drug delivery systems: an overview. Int J Pharm Tech Res 2(1): 33-45.
Trotta M (2001). Emulsion containing partially water-miscible solvents for the preparation of drug nanosuspensions. J Cont Rel 76(1-2): 119-128.
Zhang JH, Zhu JB, Chen XJ, Zhao R, Gang YY, Wu ZH, Cheng K, and Xu XY (2001). Pharmacokinetics and bioavailability of sustained release and conventional formulation of acyclovir. Eur J Drug Metab Pharmacokinet 26(3): 145-148.