A Therapeutic Approach of Essential Oils based on Aromatic Plants in the Treatment of Leishmaniasis and Vitiligo

DOI:

https://doi.org/10.37285/ijpsn.2023.16.2.9

Authors

  • Subhashree Patra Institute of Environment and Sustainable development, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh-221005
  • Meghraj Suryawanshi Department of Pharmaceutics and Pharmaceutical Technology, Indukaka Ipcowala College of Pharmac
  • Ankita Bhavsar Department of Pharmaceutics and Pharmaceutical Technology, Indukaka Ipcowala College of Pharmacy
  • Swati Kurtkoti 2Department of Pharmaceutics and Pharmaceutical Technology, Indukaka Ipcowala College of Pharmacy
  • Harsha Patel Department of Pharmaceutics and Pharmaceutical Technology, Indukaka Ipcowala College of Pharmacy
  • Sushil Raut Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018

Abstract

Aromatic plants possessing medicinal and bioactive features are the optimistic treatments for irremediable diseases like Leishmaniasis and vitiligo. Leishmaniasis, a lethal disease with over 350 million affected people, has made it a growing concern due to its non-effectual drugs and increasing pathogenic resistance. While vitiligo with globally 1% inhabitants suffering from an autoimmune disorder of depigmentation as macules on skin. Both diseases have two common characteristics: affecting the quality of life; chances of relapse due to ineffectiveness and short-lived treatments. For leishmaniasis, pentavalent antimonials in intravenous mode are the propitious large-scale approach; oral drug miltefosine and liposomal amphotericin B have been in use for a long term. Various combination therapies of paromomycin, sitamaquine, and pentamidine with antimonials up to some extent have delimited the degree of reoccurrence. However, the cost-ineffectiveness, short-term, and detrimental side effects are the roots of failure. Treatment via topical drugs, phototherapies, and surgeries has delimited effectiveness for vitiligo. This review studies the therapeutic approach of a total of 16 essential oils from plants in treating Leishmaniasis and vitiligo with efficacy and long-term effects. Among the 6 EOs notable effect of Bergamot oil with nano-lipid formulations manifested potential for permanent repigmentation. This review also noted the promising potentiality of essential oil mono-therapies, its combination utilities with current drugs could be the active and potential approach to treatment. Such as the combination anti-leishmanial effect of Curcumin and eucalyptus essential oil with miltefosine and glucantime respectively. The phenomenal effects of essential oil from Tetradenia riparia suggested notable anti-leishmanial and immunological responses towards Leishmania and could be utilized as an Anti-leishmanial drug with further insights.

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Keywords:

Leishmaniasis, Vitiligo, Traditional treatments, Combination therapies, Aromatic Plants, Essential oils

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Published

2023-05-01

How to Cite

1.
Patra S, Suryawanshi M, Bhavsar A, Kurtkoti S, Patel H, Raut S. A Therapeutic Approach of Essential Oils based on Aromatic Plants in the Treatment of Leishmaniasis and Vitiligo. Scopus Indexed [Internet]. 2023 May 1 [cited 2024 May 20];16(2):6466-79. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/3650

Issue

Vol. 16 No. 2 (2023): March-April 2023

Section

Review Articles
Crossref
Scopus
Google Scholar
Europe PMC

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