Quantum Dots as Drug Delivery Vehicles: An Abeyant Leap in Cancer Therapy
Quantum Dots as potential drug carriers
DOI:
https://doi.org/10.37285/ijpsn.2024.17.1.10Abstract
Cancer therapy encounters challenges with conventional approaches, including issues related to poor drug solubility, stability, and non-specific targeting. Quantum dots (QDs), nanocarriers exhibiting unique electrical and optical properties, present a promising solution for targeted drug delivery in cancer management. This review focuses on QDs as nanocarriers, examining their physicochemical properties, development of "smart" nanomaterials, and surface functionalization. The utilization of semiconductor, metal, and carbon-based QDs for drug delivery and imaging applications in preclinical and clinical settings is explored. Considerations pertaining to QD toxicity, biocompatibility, and recent advancements in toxicity mitigation are addressed. The review highlights challenges such as scalability, regulatory approval, and clinical translation. While possessing substantial potential, further research is necessary to tackle these challenges. The article concludes by discussing future perspectives and opportunities for enhancing QD-based drug delivery systems, thus contributing to advancements in cancer therapy.
Downloads
Metrics
Keywords:
Quantum Dots, Cancer therapy Nanomaterials, Targeted drug deliveryPublished
How to Cite
Issue
Section
References
Liu G, Yang L, Chen G, Xu F, Yang F, Yu H, et al. A Review on Drug Delivery System for Tumor Therapy. Frontiers in Pharmacology. 2021;12.
Senapati S, Mahanta AK, Kumar S, Maiti P. Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduction and Targeted Therapy. 2018;3.
Yao Y, Zhou Y, Liu L, Xu Y, Chen Q, Wang Y, et al. Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance. Frontiers in Molecular Biosciences. 2020;7:558493.
Navya PN, Kaphle A, Srinivas SP, Bhargava SK, Rotello VM, Daima HK. Current trends and challenges in cancer management and therapy using designer nanomaterials. Nano Convergence. 2019;6(1):1-30.
Maxwell T, Campos MG, Smith S, Doomra M, Thwin Z, Santra S. Quantum dots. InNanoparticles for Biomedical Applications 2020 Jan 1 (pp. 243-265). Elsevier..
Beri D. Silicon quantum dots: surface matter, what next?. Materials Advances. 2023..
Kargozar S, Hoseini SJ, Milan PB, Hooshmand S, Kim H-W, Mozafari M. Quantum Dots: A Review from Concept to Clinic. Biotechnology Journal. 2020;15(12):2000117.
Bailey RE, Smith AM, Nie S. Quantum dots in biology and medicine. Physica E: Low-dimensional Systems and Nanostructures. 2004;25(1):1-12.
Wagner AM, Knipe JM, Orive G, Peppas NA. Quantum dots in biomedical applications. Acta Biomaterialia. 2019;94:44-63.
Edis Z, Wang J, Waqas MK, Ijaz M, Ijaz M. Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives. International Journal of Nanomedicine. 2021;16:1313.
Yong K-T, Wang Y, Roy I, Rui H, Swihart MT, Law W-C, et al. Preparation of Quantum Dot/Drug Nanoparticle Formulations for Traceable Targeted Delivery and Therapy. Theranostics. 2012;2(7):681.
Baig MS, Suryawanshi RM, Zehravi M, Mahajan HS, Rana R, Banu A, et al. Surface decorated quantum dots: Synthesis, properties and role in herbal therapy. Frontiers in Cell and Developmental Biology. 2023;11:1139671.
Nanoparticle Quantum Dot - an overview | ScienceDirect Topics. 2023.
Cotta MA. Quantum Dots and Their Applications: What Lies Ahead? ACS Applied Nano Materials. 2020;3(6):4920-4.
Kulkarni NS, Guererro Y, Gupta N, Muth A, Gupta V. Exploring potential of quantum dots as dual modality for cancer therapy and diagnosis. Journal of Drug Delivery Science and Technology. 2019;49:352-64.
Zhao M-X, Zhu B-J. The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy. Nanoscale Research Letters. 2016;11(1):1-9.
Ruzycka-Ayoush M, Kowalik P, Kowalczyk A, Bujak P, Nowicka AM, Wojewodzka M, et al. Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells. Cancer Nanotechnology. 2021;12(1):1-27.
Bentolila LA, Ebenstein Y, Weiss S. Quantum Dots for In Vivo Small-Animal Imaging. Journal of Nuclear Medicine. 2009;50(4):493-6.
Gil HM, Price TW, Chelani K, Bouillard J-SG, Calaminus SDJ, Stasiuk GJ. NIR-quantum dots in biomedical imaging and their future. iScience. 2021;24(3):102189.
Abdellatif AAH, Younis MA, Alsharidah M, Al Rugaie O, Tawfeek HM. Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential. International Journal of Nanomedicine. 2022;17:1951.
Hardman R. A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors. Environmental Health Perspectives. 2006;114(2):165.
Zhong L, Zhang L, Li Y, Liang X, Kong L, Shen X, et al. Assessment of the Toxicity of Quantum Dots through Biliometric Analysis. International Journal of Environmental Research and Public Health. 2021;18(11).
Zhu C, Chen Z, Gao S, Goh BL, Samsudin IB, Lwe KW, et al. Recent advances in non-toxic quantum dots and their biomedical applications. Progress in Natural Science: Materials International. 2019;29(6):628-40.
Sun H, Zhang F, Wei H, Yang B. The effects of composition and surface chemistry on the toxicity of quantum dots. Journal of Materials Chemistry B. 2013;1(47):6485-94.
Liu N, Tang M. Toxicity of different types of quantum dots to mammalian cells in vitro: An update review. Journal of Hazardous Materials. 2020;399:122606.
Wagner AM, Knipe JM, Orive G, Peppas NA. Quantum Dots in Biomedical Applications. 2019.
Abdellatif AAH, Younis MA, Alsharidah M, Al Rugaie O, Tawfeek HM. Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential. International Journal of Nanomedicine. 2022;17:1951-70.
Sun M, Hoffman D, Sundaresan G, Yang L, Lamichhane N, Zweit J. Synthesis and characterization of intrinsically radiolabeled quantum dots for bimodal detection. American Journal of Nuclear Medicine and Molecular Imaging. 2012;2(2):122.
Das R, Bandyopadhyay R, Pramanik P. Carbon quantum dots from natural resource: A review. Materials today chemistry. 2018 Jun 1;8:96-109.
Nair A, Haponiuk JT, Thomas S, Gopi S. Natural carbon-based quantum dots and their applications in drug delivery: A review. Biomedicine & Pharmacotherapy. 2020 Dec 1;132:110834.
Iravani S, Varma RS. Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review. Environmental chemistry letters. 2020 May;18:703-27.
Michler P, editor. Quantum dots for quantum information technologies. Berlin: Springer; 2017 Jun 1.
Liu RS, editor. Phosphors, up conversion nano particles, quantum dots and their applications. Berlin/Heidelberg, Germany: Springer; 2017.
Campuzano S, Yáñez-Sedeño P, Pingarrón JM. Carbon dots and graphene quantum dots in electrochemical biosensing. Nanomaterials. 2019 Apr 19;9(4):634.
Gaur M, Misra C, Yadav AB, Swaroop S, Maolmhuaidh FÓ, Bechelany M, Barhoum A. Biomedical applications of carbon nanomaterials: fullerenes, quantum dots, nanotubes, nanofibers, and graphene. Materials. 2021 Oct 11;14(20):5978.
Huang C, Dong H, Su Y, Wu Y, Narron R, Yong Q. Synthesis of carbon quantum dot nanoparticles derived from byproducts in bio-refinery process for cell imaging and in vivo bioimaging. Nanomaterials. 2019 Mar 7;9(3):387.
Paulo S, Palomares E, Martinez-Ferrero E. Graphene and carbon quantum dot-based materials in photovoltaic devices: From synthesis to applications. Nanomaterials. 2016 Aug 25;6(9):157.
Reshma VG, Mohanan PV. Quantum dots: Applications and safety consequences. Journal of Luminescence. 2019 Jan 1;205:287-98.
Jamieson T, Bakhshi R, Petrova D, Pocock R, Imani M, Seifalian AM. Biological applications of quantum dots. Biomaterials. 2007 Nov 1;28(31):4717-32.
Wagner AM, Knipe JM, Orive G, Peppas NA. Quantum dots in biomedical applications. Acta biomaterialia. 2019 Aug 1;94:44-63.
Wang Y, Hu A. Carbon quantum dots: synthesis, properties and applications. Journal of Materials Chemistry C. 2014;2(34):6921-39.
Bera D, Qian L, Tseng TK, Holloway PH. Quantum dots and their multimodal applications: a review. Materials. 2010 Mar 24;3(4):2260-345.
Zhao C, Wang X, Yu L, Wu L, Hao X, Liu Q, Lin L, Huang Z, Ruan Z, Weng S, Liu A. Quaternized carbon quantum dots with broad-spectrum antibacterial activity for the treatment of wounds infected with mixed bacteria. Acta Biomaterialia. 2022 Jan 15;138:528-44.
Cheng-fei Z, Wang X, Yu L, Wu L, Hao X, Qicai L, Li-qing L, Huang Z, Weng S, Liu A, Lin X. Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria.
Paris-Robidas S, Brouard D, Emond V, Parent M, Calon F. Internalization of targeted quantum dots by brain capillary endothelial cells in vivo. Journal of Cerebral Blood Flow & Metabolism. 2016 Apr;36(4):731-42.