Formulation and Evaluation of Terbinafine Hydro-chloride Loaded Microsponges Gel
DOI:
https://doi.org/10.37285/ijpsn.2023.16.6.3Abstract
Background: Microsponges are porous, polymeric microspheres employed for sustained topical treatment. They may modify the release pattern, lessen adverse effects, and improve stability. Terbinafine HCL is a fungicidal allylamine derivative with a wide range of antifungal activity. It is used to treat various skin disorders like ringworm, athlete’s foot, and jock itch.
Objective: The aim of the current study focuses on the development of terbinafine HCL microsponges that will release the drug in a sustained pattern to prevent side effects and then put those microsponges into a gel.
Method: The quasi-emulsion solvent diffusion method was employed to develop Microsponges by using various drug: polymer ratios.
Result: The results of the FTIR spectra showed that there was an absence of interaction between Terbinafine HCL and the excipients. Based on the evaluation parameter, it was found that batch MS3 showed the highest entrapment efficiency of 86.32%. Polymer EC showed better results. Microsponges and Microsponges gel showed sustained release of drug till 8 and 10 hours, respectively. The gels were shown to be stable throughout a wide temperature range, according to the stability studies.
Conclusion: It was concluded that the Microsponges release the drug in a stained manner. The production process for microsponge technology has the potential to improve patient compliance with terbinafine hydrochloride microsponge gel.
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Keywords:
Terbinafine Hydrochloride, Microsponges, Quasi-emulsion solvent diffusion method, Microsponges gel, AntifungalPublished
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References
Choudhary SV, Bisati S, Singh AL, Koley S. Efficacy and safety of terbinafine hydrochloride 1% cream vs. sertaconazole nitrate 2% cream in tinea corporis and tinea cruris: A comparative therapeutic trial. Indian J Dermatol [Internet]. 2013;58(6):457.
Malcolm JM, Darkes LJ, Scott KL. Terbinafine: a review of its use in onychomycosis in adults. American Journal of Clinical Dermatology. 2003;4(1):39–65.
Joshi G, Kaur R, Kaur H. Microsponges: a novel drug delivery system. International Research Journal of Pharmaceutical and Biosciences. 2016;3(1):1–11.
Ingale DJ, Aloorkar NH, KulkarnI AS, Patil RAP. Microsponges as innovative drug delivery systems. PCI- Approved-IJPSN [Internet]. 2012;5(1):1597–606.
Charde MS, Ghanawat PB, Welankiwar AS, Kumar J, Chakole RD. Microsponge: a Novel New Drug Delivery System: A Review. International Journal of Advances in Pharmaceutics. 2013;2(6).
Osmani RM, Moin A, Deb T, Bhosale R, Hani U. Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy. J Basic Clin Pharm [Internet]. 2016;7(2):39.
Sharma N, Banik PK. Recent advances on microsponge delivery system. Int J Pharm Sci. 2011;2(1):13–23.
Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm [Internet]. 2006;318(1–2):103–17.
Hussain H. Formulation and Evaluation of Gel-Loaded Microsponges of Diclofenac Sodium for Topical Delivery. Archana Dhyani; Divya Juyal. 2014;58–63.
Pandit AP, Patel SA, Bhanushali VP, Kulkarni VS, Kakad VD. Nebivolol-loaded microsponge gel for healing of diabetic wound. AAPS PharmSciTech [Internet]. 2017;18(3):846–54.
Ravi R, Kumar S. Formulation and evaluation of the microsponge gel for an anti acne agent for the treatment of acne. Int J Pharm Sci Res. 2013;3–8.
Maiti S, Kaity S, Ray S, Sa B. Development and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium. Acta Pharm [Internet]. 2011;61(3):257–70.
Thakur N, Jain P, Jain V. Formulation development and evaluation of transferosomal gel. J Drug Deliv Ther [Internet]. 2018;8(5):168–77.
Mehta M, Panchal A, Shah VH, Upadhyay U. Formulation and in-vitro evaluation of controlled release microsponge gel for topical delivery of clotrimazole. Int J Adv Pharm. 2012;2(2):93–101.
Mayur K, Nitin RK, Prashant J, Rajendra P, Jeevan G. Ethyl cellulose based microsponge delivery system for antifungal vaginal gels of tioconazole. J Drug Deli Therap. 2013;3(6):14–20.
Chandramouli Y, Firoz S, Rajalakshmi R, Vikram A, Yasmeen BR, Chakravarthi RN. Preparation and evaluation of microsponge loaded controlled release topical gel of acyclovir sodium. Int J Biopharm. 2012;3(2):96–102.
Metwally GF, Shukr M. Evaluation of Topical Gel Bases Formulated with Various Essential Oils for Antibacterial Activity against Methicillin-Resistant Staphylococcus Aureus. Tropical J Pharm Res. 2013;12:877–84.
Saboji JK, Manvi FV, Gadad AP, Patel BD. Formulation and evaluation of ketoconazole microsponge gel by quasi emulsion solvent diffusion. J Cell Tissue Res. 2011;11(1):2691–6.
Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67(3):217–23.
WHO-GMP and ICH stability testing guidelines for drug products, The Pharmaceutical Sciences - Pharma Pathway.
