Synthesis and Evaluation of 2, 3, 4, 6-Tetra-Substituted-2, 3-Dihydropyridine Derivatives as Novel Antimicrobial Agents

Abstract

The present study has been carried out to synthesize and screen certain heterocyclic antimicrobial compounds with clues from the biologically potent activities of heterocyclic compounds containing pyridine. With a view to synthesize some biologically active compounds, it has been felt worthwhile to study the synthesis of 2, 3, 4, 6-tetra-substituted-2,3-dihydro pyridine derivatives (7a-t). They were synthesized by the condensation of respective 2-amino-2,3-dihydropyridines with different aromatic aldehydes. 7a-t were purified and characterized by physical and spectral methods (IR, 1HNMR & MS). All the compounds were evaluated for their antimicrobial activity by the agar diffusion method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Candida albicans and Saccharomyces cerevisiae. All the compounds exhibited mild to moderate antibacterial & antifungal activity. Among these compounds, compound 7h (R= Cl, R1=Cl) showing greater inhibitory activity against all tested organisms employed with zones inhibition of 20 to 15 mm at a concentration of 150 μ g/mL. Compounds 7g, 7c, 7i and 7j have been found as the next in the order of its antimicrobial potency. These compounds have the potential as novel antimicrobial agents.