Investigation of Depressant Activity of an Ayurvedic Churna in Mice: A Preliminary Study

DOI:

https://doi.org/10.37285/ijpsn.2009.2.4.16

Authors

  • Shruti Rathor School of Pharmacy, Chouksey Engineering college, Bilaspur
  • Alpana Ram S.L.T. Institute Of Pharmaceutical Sci. Guru Ghasidas University, Bilaspur

Abstract

The history of herbal medicines is as old as human civilization. Ayurved-Ancient science of life is believed to be prevalent for last 5000 years in India. It is one of the most noted systems of medicine in the world. One medicinal formulation churna subdues excitement and calms the subject without inducing sleep, though drowsiness may be produced. It gives sedation, with decreased responsiveness to any level of stimulation and associated decrease in motor activity and ideation. This churna of the roots of vatjata (Ficus bingalensis), sariva (Hemidasmus indicus), manjistha (Rubia cardifolia) and jatamansi (Nordostachys jatamansi) have been used by Ayurvedic practitioner in rural Chhattisgarh to calm down the patient. It is a mixture of fine powder of the above components. However no phytochemical investigations of these roots have been conducted so far to substantiate practice of Ayurved. The current study is aimed to explore the neuropharmacological potential of Churna. The central inhibitory effects of the Churna (from Ayurvedic Formulary) were investigated in mice to provide scientific evidence. Churna is a mixture of fine powder of Manjistha, Sariva, Vatjata and Jatamansi and decoction of drugs (watery extract). T

Downloads

Download data is not yet available.

Keywords:

Churna, Actophotometer, Rota Rod, Analgesic Activity

Downloads

Published

2009-01-31

How to Cite

1.
Rathor S, Ram A. Investigation of Depressant Activity of an Ayurvedic Churna in Mice: A Preliminary Study. Scopus Indexed [Internet]. 2009 Jan. 31 [cited 2024 Dec. 22];2(4):790-4. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/3963

Issue

Section

Short Communication

References

Adzu S, Amos S, Dzarma CW and Gamaniel K. Effect of Zizypus spin-christi wild aqueous extract on the central nervous system in mice. J. Ethanopharmacol, 79:23-16 (2001).
Al-Naggar, Gómez-Serranillos MP, Carretero ME, and Villar AM. Neuropharmacological activity of Nigella sativa L. extracts. Journal of Ethnopharmacology, 88(1):63-68 (2003).
Amos B, Adzu L, Binda CW and Gamaniel K. Behavioural effects of the aquous extract of Guiera senegalensisi in mice and rats. Phytomedicine, 8:356-361 (2001).
Balamurgan K, Dey A, and Shivkumar G. Some neuropharmacological effects of the crude extract of Conus parvatus in mice. Pakistan J. of Biological Sciences, 10(22):4136-4139 (2007).
Bruneton J. Pharmacognosy, phytochemistry of medicinal plant, II edition, Intercept, Newyork, 1999.
Dubois MA, Ilyas M, and Wagnar H. Cussonoids A and B triterpenes-saponins from Cussonia barteri. Planta medica, 56:80-83 (1986).
Dunham NW, Miya TS. A note on a simple apparatus for detecting neurological deficit in rats and mice. J. Am. Pharm. Assocs. 46:208-209 (1957).
Fujimori H, and Cobb D. Potentiation of barbital hypnosis as an evalution method for central nervous system depressant. Psychopharmacology, 7:374-377 (1965).
Graybiel AM Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci., 13:244-254 (1990).
Kirtikar & Basu. Indian Medicinal Plants, Oriental Enterprises, Uttaranchal, 2001.
Kulkarni SK. Handbook of Experimental Pharmacology, II Edition. Vallabh Prakashan, Delhi, 1999.
Lioyd GK, and Williams M. Neuronal nicotinic acetylcholine receptors as novel drug targets. J. Pharmacol., 292:461-467 (2000).
Manna S, Bhattacharyya D, Mandal TK, Dey S. Neuropharmacological effects of alfa-cypermethrin in rats. Indian J. Pharmacol, 37(1):18-20 (2005).
Ming-Chin L. Studies on the sedative effect of Cistanche deserticola. J. of Ethanopharmacol., 59: 161-165 (1998).
Ming-Chin L. Studies on the sedative effect of Cistanche deserticola. J. Ethanopharmacol., 59: 161-165 (1998).
Ozturk Y, Ayadini S, Beis R, Baser KHC and Berberoglu H. Effect of Hypericum pericum L. and Hypericum calycinum L. extracts on the CNS in mice. Phytomedicine, 3:139-146 (1996).
Pauly JR, Robinson SF, Collins AC. Chronic corticosterone administration enhances behavioral sensitization to amphetamine in mice. Brain Res., 620:195-202 (1993).
Pourgholami MH, Kamalinejad M, Javadi M, Majzoob S and Sayyah M. Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. J. of Ethnopharmacol., 64(2):167-171 (1999).
S Amos S, Binda L, Chindo BA, Tseja A, Odutola AA., Wambebe C, Gamaniel K. Neuropharmacological Effects of Hibiscus sabdariffa Aqueous Extract. Pharmaceutical Biology, 41(5):325-329 (2003).
Salawu OA, Iyanniwura TT, Adaudi AO. Effects of anticonvulsants on acute cypermethrin poisoning in mice and rats. Vet. Hum. Toxicol., 42, 303-5(2000).
Sharma AP. Dravyagun Shastra, Choukhambha Bhartiya Academy Distributors & Publishers, Part II, 1991.
Staatz CG, Bloom AS, Lech JJ. A pharmacological study of pyrethroid neurotoxicity in mice. Pest. Biochem. Physiol., 17:287-92 (1982).
Turner RA. Anticonvulsant in Screening methods in pharmacology. New York and London: Academic Press; 1:64-9 (1965).
Upadhyay R. Upayogi jadi-bootiyan chitra, parichya & prayog, published by Randhir Prakashan, haridwar, 1985.
Varshneya C, Kanwar RS. Pharmacodynamic interactions of cypermethrin and centrally acting drugs in mice. Indian J. Physiol Pharmacol, 39:154-6 (1995).
Vezina P, Stewart J. The effect of dopamine receptor blockade on the development of sensitization to the locomotor activating effects of amphetamine and morphine. Brain Res., 499:108-120 (1989).
Vongtau HO, Abbah J, Chindo BA, Mosugu O, Salawu AO, Kwanashie HO, Gamaniel KS. Central Inhibitory Effects of the Methanol Extract of Neorautanenia mitis Root in Rats and Mice. Pharmaceutical Biology, 43(2):113 – 120 (2005).