Floating Microspheres: Recent Trends in the Development of Gastroretentive Floating Drug Delivery System

DOI:

https://doi.org/10.37285/ijpsn.2011.4.1.2

Authors

  • Ch Niranajan Patra
  • Dutta P.
  • Sruti J
  • M.E. Bhanoji Rao

Abstract

 Oral controlled release systems are designed to release the drug in-vivo with prediction so as to increase efficacy, minimize adverse effects and increase bioavailability of drugs. Floating drug delivery systems (FDDSs) are expected to remain buoyant in a lasting way upon the gastric contents.  The various buoyant preparations include hollow microspheres, granules, powders, tablets, capsules, pills and laminated films. Floating microspheres are especially gaining attention due to their wide applicability in the targeting of drugs to the stomach. These floating microspheres have the advantage that they remain buoyant and distributed uniformly over the gastric fluid to avoid the vagaries of gastric emptying and release the drug for prolonged periods of time. Multiparticulate low-density particles can successfully prolong the gastric retention time of drugs. This article provides an overview of two important approaches utilized to prepare and improve the performance of floating microspheres.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2011-05-31

How to Cite

1.
Patra CN, P. D, J S, Rao MB. Floating Microspheres: Recent Trends in the Development of Gastroretentive Floating Drug Delivery System. Scopus Indexed [Internet]. 2011 May 31 [cited 2024 Nov. 19];4(1):1296-30. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/406

Issue

Vol. 4 No. 1 (2011): April-June 2011

Section

Review Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Bhowmik D, Chiranjib B, Chandira M, Jayakar B, Sampath Kumar K. P. Floating Drug Delivery System-A Review, Scholars Research Library. Der Pharmacia Lettre. 1 (2): 199-218 (2009).

Chawla C, Gupta P, Koradia V, Bansal A K. Gastroretention: A Means to Address Regional Variability in intestinal drug Absorption. Pharmaceutical technology. 27(2): 50-68 (2003).

Chickering D E, Jacob J S and Mathowitz E. Bioadhesive microspheres II: Characterisation and evaluation of bioadhesion involving hard, bioerodible polymers and soft tissue. Reactive Polymers. 25: 189–206 (1995).

Chien Y W, Controlled and Modulated Release Drug Delivery Systems in Encyclopedia of Pharmaceutical Technology, J. Swarbrick, J.C. Boylan, Eds., Marcel Dekker Inc., New York, 1990, pp. 280-285.

Cremer K. Drug delivery: gastro-remaining dosage forms. The Pharm. Journal. 19(108): 259 (1997).

Franz M R, Oth M P. Sustained release, bilayer buoyant dosage form. US Pat 5, 232, 704, August 3 (1993).

Garg S and Sharma S. Gastroretentive Drug Delivery System. Business Briefing. Pharmatech. 13(1): 160-166 (2003).

Harrigan R M. Drug delivery device for preventing contact of undissolved drug with the stomach lining. US Pat 4, 055, 178, October 25 (1977).

http://dreamurlife.blogspot.com/2007/08/floating-drug-delivery-system.html, August 12, 2007.

Ichikawa M, Watanabe S, Miyake Y. A new multiple-unit oral floating dosage system. II: In-vivo evaluation of floating and sustained-release characteristics with para amino benzoic acid and iso sorbide di nitrate as model drugs. J Pharm Sci. 80 1153-1156 (1991).

Ingani H M, Timmermans J, Moes A J. Conception and in-vivo investigation of peroral sustained release floating dosage forms with enhanced gastrointestinal transit. Int J Pharm. 35: 157-164 (1987).

Jain N K. Controlled Novel Drug Delivery. Ist Eds., CBS Publishers and Distributors, New Delhi (2002), pp.236-55.

Jain S K, Agrawal G P and Jain N K. Floating Microspheres as Drug Delivery System: Newer Approaches. Current Drug Delivery. 5: 220-223 (2008).

Kawashima Y, Niwa T, Takeuchi H, Hino T, Ito Y. Hollow microspheres for use as a floating controlled drug delivery system in the stomach. J Pharm Sci. 81: 135-140 (1992).

Kawashima Y, Niwa T, Takeuchi H, Hino T, Ito Y. Preparation of multiple unit hollow microspheres (microballoons) with acrylic resin containing tranilast and their drug release characteristics (in-vitro) and floating behavior (in-vivo). J Control release. 16: 279-290 (1991).

Khan F, MD. Shaikhul M I R, MD. Khan Z R, Mohammad A K A, Chowdhury J A and MD. Reza S. Theophylline loaded gastroretentive floating tablets based on hydrophilic polymers: preparation and in-vitro evaluation. Pak. J. Pharm. Sci. 22(2): 155-161 (2009).

Krogel I, Bodmeier R. Floating or pulsatile drug delivery systems based on coated effervescent cores. Int J Pharm. 187: 175-184 (1999).

Michaels A S, Bashwa J D, Zaffaroni A. Integrated device for administering beneficial drug at programmed rate. US Pat 3, 901, 232, August 26 (1975).

Michaels A S. Drug delivery device with self-actuated, Mechanism for retaining device in selected area, US Pat 3, 786, 813, January 22 (1974).

Ojha G, Tanwar Y S, Chauhan C S and Naruka P S. Floating Microspheres: Development, Characterization and Applications. http://www.pharmainfo.net/volume-and-issues/2006/vol-4-issue-3.

Patil J M, Hirlekar R S, Gide P S and Kadam V J. Trends in floating drug delivery systems. Journal of Scientific & Industrial Research. 65: 11-21(2006).

Sheth P R, Tossounian J. The hydrodynamically balanced system (HBSE): A novel drug delivery system for oral use. Drug Dev Ind Pharm. 10: 313-339 (1984).

Singh B N, Kim K H. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release. 63: 235–259 (2000).

Singh S, Joshi V and Barpete P K. Gastroretentive Drug Delivery System: Current Approaches. Journal of Pharmacy Research. 2(5): 881-886 (2009).

Soppimath K. S, Kulkarni A. R, Kukulkarni A. R, Rudzinski W. E, Aminabhavi T. M. Microspheres as floating drug-delivery systems to increase gastric retention of drugs. Drug Metabolism Reviews. 33(2): 149-160 (2001).

Streubel A, Siepmann J, Bodmeier R. Floating microparticles based on low density foam powder. Int. J Pharm. 241(2): (2002) 279-292.

Streubel A, Siepmann J, Bodmeier R. Multiple unit Gastroretentive drug delivery: a new preparation method for low density microparticles. J Microencapsulation. 20(3): 329-247 (2003).

Tadros M I. Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: Development, optimization and in-vitro–in-vivo evaluation in healthy human volunteers. European Journal of Pharmaceutics and Biopharmaceutics. 74 (2): 332-339 (2010).

Vyas S P & Khar, Targeted and Controlled Drug Delivery Novel Carrier System. Ist Ed., CBS Publishers and Distributors. New Delhi (2002), pp. 417-54.

Whitehead L, Fell J, Collett J H. Relevant of a gastroretentive dosage form. Eur J Pharm Sci. 4: S 182 (1996).

Yadav A, Jain D K, Balekar N, Floating Controlled Drug Delivery Systems for Prolonged Gastric Retention: A Review. The Pharma Research. 01: 133-141 (2009).