Anti-inflammatory Potential of Dapsone Loaded Chitosan Nanoparticles in Streptozotocin-Induced Experimental Dementia

DOI:

https://doi.org/10.37285/ijpsn.2011.4.1.7

Authors

  • B S Sekhon
  • Saluja V
  • D Chopra
  • N Singh

Abstract

The potential of dapsone loaded characterized chitosan nanoparticles (CSNP) as a targeted delivery was investigated in memory deficits associated with dementia of Alzheimer disease type. Streptozotocin (STZ) in two doses       (3 mg/kg on 1st and 3rd day) via intracerebroventricular route was used to induce dementia in swiss albino mice.  The results showed that administration of STZ significantly impaired learning and memory based on Morris water-maze (MWM) test and raised myeloperoxidase (MPO) level along with neutrophils infiltration density (based on brain myeloperoxidase activity along with histological studies). Dapsone (1 mg/kg & 2 mg/kg for 11 days) loaded CSNP significantly attenuated STZ induced memory impairment as well as brain MPO activity along with increased neutrophils infiltration.

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Keywords:

Chitosan nanoparticles;, dementia, streptozotocin, dapsone, myeloperoxidase activity

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Published

2011-05-31

How to Cite

1.
Sekhon BS, V S, Chopra D, Singh N. Anti-inflammatory Potential of Dapsone Loaded Chitosan Nanoparticles in Streptozotocin-Induced Experimental Dementia. Scopus Indexed [Internet]. 2011 May 31 [cited 2024 Dec. 21];4(1):1347-59. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/411

Issue

Vol. 4 No. 1 (2011): April-June 2011

Section

Research Articles
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Europe PMC

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