A Review on Analytical Methods for Determination of Azithromycin
DOI:
https://doi.org/10.37285/ijpsn.2024.17.4.8Abstract
Azithromycin treatment has been associated with a decrease in ventilation time and death in several viral infections. It possesses immune-modulating properties, including the capacity to inhibit cytokine production, preserve the integrity of epithelial cells, and prevent lung fibrosis. Primary hepatic metabolism is the process by which drugs are broken down into inactive metabolites that keep their biological effects. These prompted numerous studies and publications that used a variety of analytical techniques to find, evaluate, and investigate azithromycin and its metabolites. This review aims to provide an overview of the various analytical techniques—such as voltammetry, flow injection, hyphenated mass spectrometry, and chromatography—that have been published for the years 1990 to 2020 in order to determine azithromycin. While azithromycin was most commonly quantified using high-performance liquid chromatography, the study's results indicate that when compared to alternative techniques, liquid chromatography-mass spectrometry had the highest sensitivity, with a limit of detection of 0.0005 µg/mL.
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Azithromycin, Determination, Analytical Methods, Antibiotics, Drug, ReviewPublished
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