Formulation, Development, Characterization and Solubility Enhancement of Amisulpride
DOI:
https://doi.org/10.37285/ijpsn.2024.17.4.4Abstract
Background: Amisulpride (AMP) is a drug that is poorly water-soluble and is typically characterized by high molecular weights, significant log P values, and low bioavailability. Poor water solubility of a drug is caused by strong intermolecular interaction and a drug's affinity for a lipid environment (lipophilicity).
Objective: The current study aims to improve Amisulpride's (AMP) oral bioavailability and solubility by developing a complex with 2-hydroxypropyl β-cyclodextrin (HP-β-CDT).
Method: This study describes solubility of AMP with β-CDT and HP-β-CDT. Prepared inclusion complex of AMP and HP-β-CDT by different techniques like physical mixture, kneading and lyophilization.
Result: A notable improvement in AMP's solubility was obtained with an optimized inclusion complex. The result of FT-IR, DSC and XRD confirms the complex between AMP and HP-β-CDT. The physical mixture, kneading and lyophilization technique, the kneading method is most successful in producing an inclusion complex.
Conclusion: The 1.3 ratio gives the best drug content and dissolution profile.
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Keywords:
Amisulpride (AMP), Inclusion complex, HP-β-CDT, solubility enhancement, bioavailabilityPublished
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References
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