Effect of Combination of Alcoholic Extract of Zingiber Officinale (AEZO) and Hydroalcoholic Extract of Brassica Oleracea (HAEBO) on Papain Induced Osteoarthritis in Wistar Rats
DOI:
https://doi.org/10.37285/ijpsn.2024.17.5.5Abstract
Background: The “degenerative joint disease” i.e. Osteoarthritis (OA) is very common nowadays, which affects generally the knee joints. Osteoarthritis occurs in all the synovial joints of the hand, spine, wrist, hip, knee, and ankles. While we are focusing on the current Indian scenario, it was found that the prevalence rate of osteoarthritis ranges from 22-39 percent. Overall, it often affects both males and females after the age of 45. It affects more than 500 million people globally. Age, weight, gender, joint damage, and heredity were additional risk factors for OA. Osteoarthritis causes pain, functional limitation, and deterioration. Herbal remedies can be used to treat such diseases.
Methods: The alcoholic extract of Zingiber officinale (AEZO) and the hydroalcoholic extract of Brassica oleracea (HAEBO) in 1:1 proportion were evaluated against papain-induced OA.
Evaluation: The paw volume, blood and liver parameters, serum calcium level, histopathology, and radiology were performed once after the treatment of 28 days with the combination.
Result: The results of the combination of AEZO and HAEBO-treated groups show that paw volume was reduced but the percentage of paw edema is enhanced. The histological and radiological results also indicated that a mixture of AEZO and HAEBO in 1:1 proportion has anti-osteoarthritic activity in papain-induced osteoarthritis.
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Keywords:
Osteoarthritis, Synovial inflammation, Anti-citrullinated protein antibody, Zingiber officinal, Brassica oleracea
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References
Martel-Pelletier J. Pathophysiology of osteo-arthritis. Osteoarthritis and cartilage. 1999 Jul 1;7(4):371-3.
Ashkavand Z, Malekinejad H, Vishwanath BS. The pathophysiology of osteoarthritis. Journal of Pharmacy Research. 2013 Jan 1;7(1):132-8.
Pal CP, Singh P, Chaturvedi S, Pruthi KK, Vij A. Epidemiology of knee osteoarthritis in India and related factors. Indian journal of orthopaedics. 2016 Oct;50(5):518-22.
Zhang W, Ouyang H, Dass CR, Xu J. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone research. 2016 Mar 1;4(1):1-4.
Bramono DS, Richmond JC, Weitzel PP, Kaplan DL, Altman GH. Matrix metalloproteinases and their clinical applications in orthopaedics. Clinical Orthopaedics and Related Research®. 2004 Nov 1;428:272-85.
Kuyinu EL, Narayanan G, Nair LS, Laurencin CT. Animal models of osteoarthritis: classification, update, and measurement of outcomes. Journal of orthopaedic surgery and research. 2016 Dec;11(1):1-27.
Hunter DJ, McDougall JJ, Keefe FJ. The symptoms of osteoarthritis and the genesis of pain. Rheumatic Disease Clinics of North America. 2008 Aug 1;34(3):623-43.
Johns RJ, Wright V. Relative importance of various tissues in joint stiffness. Journal of Applied Physiology. 1962 Sep 1;17(5):824-8.
Kong JS, Yoo SA, Kim HS, Kim HA, Yea K, Ryu SH, Chung YJ, Cho CS, Kim WU. Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothio-cyanate. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2010 Jan;62(1):159-70.
Little CB, Smith MM. Animal models of osteoarthritis. Current Rheumatology Reviews. 2008 Aug 1;4(3):175-82.
Morsy AF, Ibrahima HS, Shalabyb MA. Protective effect of broccoli and red cabbage against hepatocellular carcinoma induced by N-nitrosodiethylamine in rats. J Am Sci. 2010;6:1136-44.
Danesh E, Khatamsaz S, Shojaeifard M, Khabbaz Z. Effects of hydro-alcoholic extract of broccoli (Brassica oleracea) on sensory threshold of pain using the for-malin test in adult male rats. J. Biol. Today's World. 2014; 3:147-51.
Gaikwad DD, Shinde SK, Kawade AV, Jadhav SJ, Gadhave MV. Isolation and standardization of gingerol from ginger rhizome by using TLC, HPLC, and identification tests. The Pharma Innovation. 2017 Feb 1;6(2, Part C):179.
Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis & Rheumatism. 2001 Nov;44(11):2531-8.
Kumar S, Saxena K, Singh UN, Saxena R. Anti-inflammatory action of ginger: A critical review in anemia of inflammation and its future aspects. Int J Herb Med. 2013;1:16-20.
Grzanna R, Lindmark L, Frondoza CG. Ginger—an herbal medicinal product with broad anti-inflammatory actions. Journal of medicinal food. 2005 Jun 1;8(2):125-32.
Hossain MM, Kabir MS, Hasanat A, Kabir MI, Chowdhury TA, Kibria AS. Investigation of in vitro anti-arthritic and membrane stabilizing activity of ethanol extracts of three Bangladeshi plants. The Pharma Innovation. 2015 Mar 1;4(1, Part B):76.
Ullah HM, Zaman S, Juhara F, Akter L, Tareq SM, Masum EH, Bhattacharjee R. Evaluation of antinociceptive, in-vivo & in-vitro anti-inflammatory activity of ethanolic extract of Curcuma zedoaria rhizome. BMC complementary and alternative medicine. 2014 Dec;14(1):1-2.
