Nanosensors and their Pharmaceutical Applications: A Review
DOI:
https://doi.org/10.37285/ijpsn.2011.4.4.2Abstract
Nanotechnology research is rolling worldwide, having an impact on multiple sectors and with a general belief that medical and biological applications will form the greatest area of expansion over the next decade. This field is mainly driven by an endeavour to bring radical solutions to areas of medical need, not fulfilled presently. This article discusses the basic concepts and developments in the field of nanosensors and their applications in pharmaceutical and medicine fields. Various types of nanosensors including optical nanosensors, electrochemical nanosensors, chemical nanosensors, electrometers, biosensors, and deployable nanosensors are described. It describes the progression of this field of research from its birth up to the present, with emphasis on the techniques of sensor construction and their application to biomedical systems.
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Nanosensors, Optical nanosensors, Electrochemical nanosensors, Chemical nanosensors, Electrometers, BiosensorsDownloads
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Akyildiz IF, Jornet JM (2010). Electromagnetic wireless nanosensor networks. Nano Communication Networks 1: 3-19.
Colombo M, Ronchi S, Monti D, Corsi F, Trabucchi E and Prosperi D (2009). Femtomolar detection of autoantibodies by magnetic relaxation nanosensors. Analytical Biochemistry 392: 96-102
Cullum BM, Vo-Dinh T (2003). Optical Nanosensors for biological applications-spectroscopic techniques at the cellular level. In: Advanced Semiconductor and Organic Nano-Techniques (Part III), 225-250.
Cullum BM, Vo-Dinh T (2000). The development of optical nanosensors for biological measurements. In: TIBTECH, Vol. 18: 388-393.
Cusano A, Giordano M, Cutolo A, Pisco M and Consales M (2008). Integrated development of chemoptical fiber nanosensors. Current Analytical Chemistry 4: 296-315.
Deuschle K, Chaudhuri B, Okumoto S, Lager I, Lalonde S and Frommer WB (2006). Rapid Metabolism of Glucose Detected with FRET Glucose Nanosensors in Epidermal Cells and Intact Roots of Arabidopsis RNA-Silencing Mutants. In: The Plant Cell, Vol. 18: 2314–2325.
Devreese JT (2007). Importance of nanosensors: feynman's vision and the birth of nanotechnology. Mater. Res. Soc. Symp. Proc. Vol. 952: 1-11.
Emerich DF and Halberstadt C (2007). Nanotechnology’s impact on cell transplantation. In: Cellular Transplantation: From Laboratory to Clinic, 611-627.
Fehr M, Frommer WB and Lalonde S (2002). Visualization of maltose uptake in living yeast cells by fluorescent nanosensors. PNAS 99(15): 9846–9851.
Flinn ED (2005). Nanosensors to monitor space radiation exposure. In: Aerospace America, 14-17.
Francla GD, Alfano B and Ferrara VL (2009). Conductometric gas nanosensors. Journal of Sensors, Hindawi Publishing Corporation:659275
Fritz J., Cooper EB., Gaudet S., Sorger PK., Manalis SR (2002). Electronic detection of DNA by its intrinsic molecular charge. PNAS 99 (22): 14142–14146.
Gopel W (1996). Nanosensors and molecular recognition. Microelectronic Engineering 32: 75-110.
Horton H, Khan A and Maddison S (2006). Delivering nanotechnology to the healthcare, IT and environmental sectors— a perspective from the ‘London Centre for Nanotechnology. BT Technology Journal 24 (3): 175-183.
Jain KK (2005). The role of nanobiotechnology in drug discovery. Drug Discovery Today, (DDT), Volume 10, Number 21:1435-1442.
Jianrong C, Yuqing M, Nongyue H, Xiaohua W, Sijiao L.(2004), Nanotechnology and biosensors. Biotechnology Advances 22: 505-518.
Liu S, Yuan L, Yue X, Zheng Z and Tang Z (2008). Recent advances in nanosensors for organophosphate pesticide detection. Advanced Powder Technology 19: 419–441.
Modi A, Koratkar N, Lass E, Wei B, Ajayan PM (2003). "Miniaturized gas ionization sensors using carbon nanotubes. Nature. 424: 171–174.
Kong J, Franklin NR, Zhou C, Chapline MG, Peng S, Cho K, Dai H (2000). Nanotubes Molecular Wires as Chemical Sensors. Science 287 (5453): 622–625.
Kaittanis C, Santra S and Perez JM (2010). Emerging nanotechnology-based strategies for the identification of microbial pathogenesis. Advanced Drug Delivery Reviews 62: 408-423.
Kim YP, Daniel WL, Xia Z, Xie H and Mirkin CA (2009). Bioluminescent nanosensors for protease detection based upon gold nanoparticle-luciferase conjugates. Supplementary Material (ESI) for Chemical Communications, The Royal Society of Chemistry, 1-10
Kneipp J, Kneipp H, Wittig B and Kneipp K (2010). Novel optical nanosensors for probing and imaging live cells. Nanomedicine: Nanotechnology, Biology, and Medicine 6: 214-226.
Koehne JE, Chen H, Cassell AM, Ye Q, Han J, Meyyappan M and Li J.(2004). Miniaturized multiplex label-free electronic chip for rapid nucleic acid analysis based on carbon nanotube nanoelectrode arrays. Clinical Chemistry 50: 1886-1893
Li H, Sun J, Cullum BM (2005). Label-Free Detection of Proteins Using SERS-Based Immuno-Nanosensors. Nanobiotechnology, 17-28.
Lin YF and Liu C (2009). Smart pipe: Nanosensors for monitoring water quantity and quality in public water systems. MTAC Report TR09-03: 1-14.
Medelius P (2009). Sensors For Monitoring Air Quality In Earth And Space Environments. In: Sensors for Environment, Health and Security, 431-442
Okumoto FS, Deuschle K, Lager I, Looger LL, Persson J, Kozhukh L, Lalonde S and Frommer WB (2005). Development and use of fluorescent nanosensors for metabolite imaging in living cells. Biochemical Society Transactions, Volume 33: 287-290.
Palit S and Datta A (2010). Future healthcare: Bioinformatics, nano-sensors, and emerging innovations. In: Nanosensors: Theory and Applications, 247-312.
Patolsky F and Lieber CM (2005). Nanowire nanosensors, In: Materials today, 20-28.
Perez JM and Weissleder R (2002). Magnetic nanosensors for DNA analysis. European Cells and Materials 3(2): 181-182.
Ren H, Jiang C, Hu W, Gao M, Wang J, Wang H, He H and Liaan E (2007). The preparation of optical fibre nanoprobe and its application in spectral detection. Optics & Laser Technology 39: 1025-1029.
Riu J, Maroto A and Rius FX (2006). Nanosensors in environmental analysis. Talanta 69: 288-301.
Schellenberger E (2010). Bioresponsive nanosensors in medical imaging. Journal of Royal Society Interface 7: S83-S91.
Shrivastava S and Dash D. (2009), Applying nanotechnology to human health: Revolution in biomedical science. Journal of Nanotechnology 184: 702.
Smith S and Nagel DJ (2003). Nanotechnology-Enabled Sensors: Possibilities, Realities, and Applications. Sensors Magazine 563-574.
Tallury P, Malhotra A, Byrne LM, Santra S (2010). Nanobioimaging and sensing of infectious diseases, Advanced Drug Delivery Reviews 62: 424-437.
Urban GA (2009). Micro– and Nanosensors for medical applications, In: IFMBE Proceedings 25/VIII, 310.
Vo-Dinh T, Kasili P and Wabuyele M (2006). Nanoprobes and nanobiosensors for monitoring and imaging individual living cells. Nanomedicine: Nanotechnology, Biology, and Medicine 2: 22– 30.
Yonzon CR, Stuart DA, Zhang X, McFarland AD, Haynes CL, Duyne RPV(2005). Towards advanced chemical and biological nanosensors—An overview. Talanta 67: 438-448.
Zheng L, Li S and Burke PJ (2004). Self-assembled gold nanowires from nanoparticles: an electronic route towards DNA nanosensors, In: Nanoengineering: Fabrication, properties, optics, and devices. Proceedings of SPIE 5515: 117-124.