Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets
DOI:
https://doi.org/10.37285/ijpsn.2011.4.4.3Abstract
The present study was aimed to develop an extended release tablet of metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of hydroxylpropyl-methylcellulose K100M, sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5 cps in varying concentration were developed by direct compression. The physicochemical and in vitro release characteristics of all the formulations were investigated and compared. Two formulations, F7 and F8 have shown not more 25% drug release in 1st h, 20%-40% drug release at 4th hour, 40%-60% drug release at 8th hour and not less than 80% at 20th hour and the release pattern conform with USP specification for 24 hours extended release formulation. It can be conclusively stated that optimum concentration of HPMC K100M (58%-65%) by direct compression method can yield an extended release of metoprolol succinate for 24 hours.
Downloads
Metrics
Keywords:
Metoprolol succinate, HPMC, CMC Na, Eudragit L30 D55, extended releaseDownloads
Published
How to Cite
Issue
Section
References
Barhate AL, Santosh N. Shinde, Monali S. Sali, Kunal D. Ingale, Vishnu P.Choudhari, Bhanudas S. Kuchekar (2010). Fabrication of controlled release metoprolol succinate Matrix Tablet : Influence of some hydrophilic polymers on the release rate and in vitro evaluation. International Journal of Pharma World Research 2.
Allen VL Jr., Popovich NG and Ansel HC (2009). Ansel’s Pharmaceutical dosage form and drug delivery system, 8th edition, BI Publications Pvt Ltd, 262-266.
Banker GS and Anderson NR (1986). Tablets. In: Lachman L.Lieberman HA, Kanig JL, and editor, The theory and practice of industrial pharmacy. 3rd Edition 293-335.
Hamid A. Merchat, Harris M. Shoaib (2006). Once-daily tablet formulation and invitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A technical note. AAPS Pharma science Tec 7(3): E1 –E6.
John Wikskard, Andersson B, Kendall MJ, Stanbrook H (2003). Pharmacokinetic consideration of formulation extended release metoprolol succinate in the treatment of heart failure. Journal of Cardiovascular Pharmacology 41: 151 – 157.
Prajapati BG and Patel KR (2010). Once-Daily sustained release matrix tablets of losartan potassium:Formulation and in vitro evaluation. International Journal of Medical and Clinical Research 1:1-7.
Sasidhar RLC, Vidyadhara S, Ramesh Babu J, Nagaraju K and Prakash Reddy (2010). Formulation and evaluation of controlled release of losartan potassium matrix tablets. Curent Trends Biotechnology and Pharmacy 3: 15-21.