Formulation Development of Aceclofenac Loaded Nanosupension by Three Square (32) Factorial Design
DOI:
https://doi.org/10.37285/ijpsn.2011.4.4.9Abstract
In the present study, aceclofenac loaded polymeric nanosuspension were formulated and evaluated. Aceclofenac is a potent analgesic under BCS Class II. Due to the need for its frequent dosing, aceclofenac is an ideal candidate for sustained or controlled drug delivery. For optimization of prepared formulation, the three square (32) factorial design was used. Tween 80 (X1) and combination of Eudragit RL 100 and RS 100 (X2) were used as independent variables and particle size (Y1), entrapment efficiency (Y2), and Percent drug release (Y3) were taken as dependent variables. The formulations were evaluated for particle size, zeta potential and drug entrapment. The in vitro drug release profile supports nanosuspension form to be used as a sustained release vehicle for aceclofenac. The formulation was characterized by differential scanning calorimetric analysis, in vivo studies and stability testing.
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Keywords:
Aceclofenac, nanosuspension, particle size, factorial design
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References
Costa P, and Lobo J (2001). Modeling and comparison of dissolution profile. Eur J Pharma Sci. 13:123-133.
Gambhir M, bhalekar M, Gambhir V (2010). Development of Rifampicin Nanoparticles by 32 Factorial Design. International Journal of Pharmaceutical Sciences and Nanotechnology 3:1085-1091.
Gupta V, Karar P, Ramesh S, Misra S, Gupta A (2010).Nanoparticle Formulation for Hydrophilic & Hydrophobic Drugs. International Journal of Research Pharmaceutical Sciences 1(2):163-169.
Mishra B, Arya N, Tiwari S (2010). Investigation of formulation variables affecting the properties of lamotrigine nanosuspension using fractional factorial design. DARU 18(1):1-8.
Panchaxari D, Kerur S, Mastiholimath V, Gadad A, Kulkarni A (2009) .Polymeric ocular nanosuspension for controlled release of acyclovir: in vitro release and ocular distribution. Iranian Journal of Pharmaceutical Research 8 (2): 79-86.
Patel D, Patal J, Pandya V, Patel R (2009). Effect of formulation variables on nanosuspension containing famotidine prepared by solvent evaporation techniques. International Journal of Pharmaceutical Sciences and Nanotechnology 2(4):707-713
Patil VB, (2008) Nanosuspensions: A Novel Approach in Drug Delivery, Available from: URL: http://www. pharmainfo.net/ volumes-and issues/2008/vol-6-issue-2
Patil SA, Rane BR, Bakliwal SR, Pawar SP (2011). Nanosuspension: At a glance. International Journal of Pharmaceutical Sciences 3:947-960.
Patravale VB, Abhijit A D, Kulkarni RM (2004). Nanosuspensions: a promising drug delivery strategy. Journal of Pharmacy and Pharmacology 56:827–840.
Shabnam A, Qurratul A, Shama P (2009). An overview on various approaches used for solubilization of poorly soluble drugs. The Pharma Research (T. Pharm. Res.) 2:84-104.
Tiwari R, Pathak K (2011). Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: Comparative analysis of characteristics, pharmacokinetics and tissue uptake. International Journal of Pharmaceutics 415:232– 243.
Verma S, Diane Burgess (2010). Solid Nanosuspensions: The Emerging Technology and Pharmaceutical Applications as Nanomedicine, In: Alok K. Kulshreshtha, Onkar N. Singh, G. Michael Wall, Pharmaceutical Suspensions, From Formulation Development to Manufacturing. AAPS Press 285-318.
Vogel H (2002). Drug Discovery and Evaluation Pharmacological assays. Springer-Verlag Berlin Heidelberg New York, Second Edition, 759-763.
Xiaohui Pu, Jin Sun, Mo Li and Zhonggui He (2009). Formulation of nanosuspensions as a new approach for the delivery of poorly soluble drugs. Current Nanoscience 5: 417-427.
