Formulation and In vitro Evaluation of Mucoadhesive Buccal Patches of Ondansetron Hydrochloride
DOI:
https://doi.org/10.37285/ijpsn.2010.3.1.9Abstract
The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Ondansetron Hydrochloride (OND) which is used for nausea and vomiting associated with cancer chemotherapy and radiotherapy. Permeation of OND was calculated ex vivo using porcine buccal membrane. Buccal films were developed by solvent-casting technique using Hydroxy Propyl Methyl Cellulose(HPMC E15) as mucoadhesive polymer. The patches were evaluated for weight variation, thickness variation, surface pH, moisture absorption, in vitro residence time, mechanical properties, in vitro release, ex vivo permeation studies and drug content uniformity. The formulation F3 was found to give the better results and obeys first order kinetics.
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Keywords:
Mucoadhesive, Buccal patch, ondansetron hydrochloride, mechanical properties, in vitro studies, ex vivo studies
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Blake J.C. and Burroughs. The Pharmacokinetics of Intravenous ondansetron in patients with hepatic impairment Brit.J.Clin.Pharmacy. 35: 441 (1993).
Buket T. and Yilmaz Capan. Design and evaluation of sustained release and buccal adhesive propronolol hydrochloride tablets J. Control Release, 38: 11 (1996).
Hans E. Junginger, Janet A. Hoogstraate, J. Coos Verhoef. Recent advances in buccal drug delivery and absorption — in vitro and in vivo studies. Journal of Controlled Release, 62: 149–159 (1999).
Harris, D. Robinson, J.R. Drug delivery via the mucous membranes of the oral cavity. J. Pharm. Sci, 81: 1-10 (1992).
Hoogstraate J.A.J. and Wertz P.W, Pharm.Sci.Technol Today. 1: 309 (1998).
Junginger HE, Hoogstraate JA, Verhoef JC. Recent advances in buccal drug delivery and absorption—in vitro and in vivo studies. J Control Release.; 62: 149–159 (1999)
K.P.R. Chowdary and L. Srinivas. Mucoadhesive drug delivery systems A Review of current status Indian Drugs. 27 (9): 402 (2002).
Khar R.K. and Ahuja. Development and evaluation of Mucoadhesive Buccal tablets of lignocaine hydrochloride Indian J.Pharm.Sci. 64 (6): 564 (2002).
Luana Periolia., Valeria Ambrogia., Fausta Angelicia., Maurizio Riccia., Stefano Giovagnolia., Marinella Capuccellab., Carlo Rossia. Development of mucoadhesive patches for buccal administration of ibuprofen. J. Control. Release, 99: 73– 82 (2004).
Mashru, R., Sutariya, V., Sankalia, M., Sankalia J. Transbuccal delivery of lamotrigine across porcine buccal mucosa: in vitro determination of routes of buccal transport. J. Pharm. Pharmaceut. Sci, 8: 54–62 (2005).
Mona Semalty, Ajay Semalty, Ganesh Kumar, Vijay Jugal, Development of Mucoadhesive Buccal films of Glipizide, International Journal of Pharmaceutical Sciences and Nanotechnology, 1( 2): 184-189 (2008)
Rathbone M.J, Drummond B.K, Tucker I.G. The oral cavity as a site for systemic drug delivery, Adv. Drug Deliv. Rev. 13: 1 –22 (1994).
Steven Jay Russell J.M. Transmucosal delivery of testosterone in rabbits using novel bi-layer Mucoadhesive Wax-film composite disks Pharm. Res, 91: 2016 (2002).
T.Nagai and Y. Machida. Buccal delivery systems using hydrogels Adv Drug Del Rev, 11: 179 (1993).
Wikipedia, The free encyclopedia, http://en.wikipedia.org/wiki/.
Y. Vamshi Vishnu, K. Chandrasekhar, G. Ramesh and Y. Madhusudan Rao. Development of mucoadhesive patches for buccal administration of carvedilol Curr.Drug Del. 4: 27 (2007).
Y. Vamshi Vishnu, R Gannu, C.S. Kolli, M.E. Bhanoji Rao and Y. Madhusudan Rao. Development and in vitro evaluation of buccoadhesive carvedilol tablets Acta Pharm, 57: 185 (2007).
