Role of Vitamin E as Nutraceutical in Reproduction: A Mini Review

Authors

  • Shilpi Chauhan Lloyd Institute of Management and Technology, Plot No.-11, Knowledge Park-I1, Greater Noida
  • Poorva Kaushik Lloyd Institute of Management and Technology, Plot No.-11, Knowledge Park-I1, Greater Noida

Abstract

Vitamin E is very known essential vitamin which has its importance in skin and hair remedies. Apart from the cosmetic perspective, a number of studies established the importance of vitamin E during the reproductive process, such as preeclampsia, miscarriage, premature birth, and intrauterine growth restriction. Because of potent antioxidant properties, vitamin E can reduced the oxidative stress induced by radical oxygen species and disproportion of oxidative-antioxidant levels, hence it may play a role in maintenance of the normal functioning of both female and male reproductive system. Even though the circumstance that vitamin E is acknowledged as the substance needed for reproduction, its beneficial effects on female fertility and gynaecological health issues are still poorly understood. Therefore, the goal of this paper is to summarize the known roles of vitamin E as nutraceuticals in male and female for reproductive-related diseases, as well as its future perspective.

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Keywords:

Vitamin E, Tocopherol, Gynaecology health, Male reproductive system, Antioxidant property

Published

2024-05-14

How to Cite

1.
Chauhan S, Kaushik P. Role of Vitamin E as Nutraceutical in Reproduction: A Mini Review. Scopus Indexed [Internet]. 2024 May 14 [cited 2024 Dec. 21];15(7). Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/4814

Issue

Vol. 15 No. 7 (2022): Special Annual Issue 2022,

Section

Review Articles

References

Evans HM, Bishop KS. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science. 1922; 56: 650–651.

Ute CO-J, Lester P. Vitamin E. Encyclopedia of Biological Chemistry. 2004;384-388.

Aggarwal BB, Sundaram C, Prasad S, Kannappan R. Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases. Biochemical Pharmacology. 2010;80:1613–1631.

Mohd Mutalip SS, Ab-Rahim S, Rajikin MH. Vitamin E as an antioxidant in female reproductive health. Antioxidants. 2018 Feb;7(2):22.

Qureshi AA, Burger WC, Peterson DM, Elson CE. The structure of an inhibitor of cholesterol biosynthesis isolated from barley. Journal of Biological Chemistry. 1986;261:10544–10550.

Budin SB, Othman F, Louis SR, Abu Bakar M, Das S, Mohamed J. The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats. Clinics 2009;64:235–244.

Ramanathan N, Tan E, Loh LJ, Soh BS, Yap WN. Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities. Nutrition & Metabolism. 2018;15:6.

Kato A, Yamaoka M, Tanaka, A, Komiyama K, Umezawa I. Physiological effect of tocotrienol. Journal of Japan Oil Chemists’ Society. 1985;34:375–376.

Guthrie N, Gapor A, Chambers A, Carroll KK. Inhibition of proliferation of estrogen receptor—negative MDA-MB-435 and—positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. Journal of Nutrition. 1997;127:544S–548S.

Sen CK, Khanna S, Roy S. Tocotrienol: The natural vitamin e to defend the nervous system? Annals of the 34. New York Academy of Sciences. 2004;1031:127–142.

Makpol S, Jam FA, Khor SC, Ismail Z, Yusof YAM, Ngah WZW. Comparative effects of biodynes, tocotrienol-rich fraction, and tocopherol in enhancing collagen synthesis and inhibiting collagen degradation in stress-induced premature senescence model of human diploid fibroblasts. Oxidative Medicine and Cellular Longevity. 2013;2013:298574.

Fang F, Kang Z, Wong C. Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferatoractivated receptors. Molecular Nutrition & Food Research. 2009;54:345–352.

Behl C, Davis J, Cole GM, Schubert D. Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochemical and Biophysical Research Communications. 1992;186:944–50.

Murphy TH, Schnaar RL, Coyle JT. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. The FASEB Journal. 1990;4:1624–33.

Selvaraju TR, Khaza’Ai H, Vidyadaran S, Abd Mutalib 15. MS, Vasudevan R. The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes. Bosnian Journal of Basic Medical Sciences. 2014;14:195–204.

Owen KN, Dewald O. Vitamin E Toxicity; StatPearls: Treasure Island, FL, USA, 2022.

Bowry V, Ingold KU, Stocker R. Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochemical Journal. 1992;288(2):341–344.

Bonvehi JS, Coll FV, Rius IA. Liquid chromatographic determination of tocopherols and tocotrienols in vegetable oils, formulated preparations, and biscuits. Journal of AOAC International. 2000;3:627–634.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium, and Carotenoidsexternal link disclaimer. Washington, DC: National Academy Press, 2000.

Rizvi S, Syed TR, Faizal A, Absar A, Shania A, Farzana M. The role of vitamin e in human health and some diseases, Sultan Qaboos University Medical Journal. 2014;14(2):e157-165.

Jiang Q. Natural forms of vitamin E: Metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radical Biology and Medicine. 2014;72:76–90.

Galli F, Azzi A; Birringer M, Cook-Mills JM, Eggersdorfer M, Frank J, Cruciani G, Lorkowski S, Özer NK. Vitamin E: Emerging aspects and new directions. Free Radical Biology and Medicine. 2016;102:16–36.

Schmolz L, Birringer M, Lorkowski S, Wallert M. Complexity of vitamin E metabolism. World Journal of Biological Chemistry. 2016;7:14–43.

Monsen ER. Dietary reference intakes for the antioxidant nutrients: Vitamin C, Vitamin E, selenium, and carotenoids. Journal of the American Dietetic Association. 2000;100:637–640.

Mutalip SSM, Ab-Rahim S, Rajikin MH. Vitamin E as an antioxidant in female reproductive health. Antioxidants. 2018;7:22.

Cicek N, Eryilmaz OG, Sarikaya E, Gulerman C, Genc Y. Vitamin E effect on controlled ovarian stimulation of unexplained infertile women. Journal of Assisted Reproduction and Genetics. 2012;29:325–328.

Mokhtar NM, Rajikin MH, Zakaria Z. Role of tocotrienol-rich palm vitamin E on pregnancy and preim-plantation embryos in nicotine-treated rats. Biomedical Research. 2008;19:181–184.

Chełchowska M, Laskowska-Klita T, Leibschang J. The effect of tobacco smoking during pregnancy on concentration of vitamin E in blood of mothers and their newborns in umbilical cord blood. Ginekologia Polska. 2006;77:263–268.

Fraser WD, Audibert F, Bujold E, LeDuc L, Xu H, Boulvain M, Julien P. The vitamin E debate: Implications for ongoing trials of pre-eclampsia prevention. British journal of obstetrics and gynaecology. 2005;112:684–688.

Kamsani YS, Rajikin MH, Khan N-AMN, Satar NA, Chatterjee A. Nicotine-induced cessation of embryonic development is reversed by γ-tocotrienol in mice. Medical Science Monitor Basic Research. 2013;19:87–92.

Bahadur G, Homburg R, Al-Habib A. A new dawn for intrauterine insemination: Efficient and prudent practice will benefit patients, the fertility industry and the healthcare bodies. The Journal of Obstetrics and Gynecology of India. 2016;67:79–85.

Alvarez JG, Storey BT. Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoa. Molecular Reproduction and Development. 1995;42:334-346.

Aziz N, Saleh RA, Sharma RK, Lewis-Jones I, Esfandiari N, Thomas AJ Jr et al. Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index. Fertility and Sterility. 2004;81:349-354.

Sikka SC. Relative impact of oxidative stress on male reproductive function. Current Medicinal Chemistry. 2001;8:851-862.

Umesiobi DO. Effect of vitamin E supplementation on the libido and reproductive capacity of Large White boars. South African Journal of Animal Science. 2012c;42:5.

Hashem NM, El-Hady AA, Hassan O. Effect of vitamin E or propolis supplementation on semen quality, oxidative status and hematobiochemical changes of rabbit bucks during hot season. Livestock Science. 2013;157:520–526.

Rahman HU, Qureshi MS, Khan RU. Influence of dietary zinc on semen traits and seminal plasma antioxidant enzymes and trace minerals of Beetal bucks. Reproduction in Domestic Animals. 2014;49:1004–1007.