Studies on Immunomodulatory Activity of Capparis zeylanica Leaf Extracts
DOI:
https://doi.org/10.37285/ijpsn.2010.3.1.14Abstract
The methanolic and aqueous extracts of Capparis zeylanica are known to exhibit immunomodulatory activity. In the present investigation, the effect of ethonolic extract and its fractions on cellular humoral functions in mice have been studied. Alcoholic extract revealed significant (ANOVA followed by Dunnett’s Multiple Comparison test) immunostimulation by in-vitro phagocytosis, delayed hypersensitivity and haemagglutination model. Oral administration of EFCZ (ethyl acetate fraction) and NFCZ (n-butanol fraction) among the four fractions (20-40 mg/kg) significantly inhibited sheep red blood cells (SRBC) – induced delayed type hypersensitivity reactions and significantly increased the in vitro phagocytic index. It also produced a significant, dose related decrease in sheep erythrocyte specific heamagglutination antibody titre. The results obtained indicate the ability of the EFCZ and NFCZ fraction of Capparis zeylanica to modulate both cell mediated and the humoral components of the immune system.
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Immunomodulatory activity, Phagocytosis, Delayed hypersensitivity, Capparis zeylanica
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