Formulation and Evaluation of a Novel Wheat Dextrin-Based Polysaccharide and Ethyl Cellulose Coated Multiparticulates for Colonic Bacterial Enzyme Dependent Colon Targeted Drug Delivery of Otilonium Bromide

Abstract

Introduction: A site-specific drug delivery system is one that alters the formulation to deliver the medication to a particular target or the location of the sickness. The drug is targeted to the colon in a colon-specific drug delivery approach, which is helpful in the management of several colon-related disorders like inflammatory bowel disease, crohn's disease, colon cancer, etc. It also reduces the need for high doses of the drug, reducing dosage frequency, unwanted side effects, and drug cost. 

Methods: Colon-specific delivery of drug can be accomplished by either a time dependent release model or a pH dependent model or the colonic bacterial enzyme dependent release model. This last method utilizes the colonic anaerobic bacterial enzymes to break the special polymers in use, to liberate drug at the colon. The digestion of natural polysaccharides by gut flora enzymes like pectinase and amylase makes them ideal for colon-specific medication delivery. 

Result: In this study, emphasis is placed on using the polysaccharide Nutriose (FB 06) for colon-specific drug delivery while using ethyl cellulose (EC 45) as a copolymer to coat drug-loaded pellets of the antispasmodic  medication otilonium bromide, which were made from nonpareil sugar seeds using a powder layering technique. 

Conclusion: FT-IR and DSC studies have been performed to ascertain the possibilities of any drug-polymer incompatibility. In-vitro dissolution studies are also conducted to optimize a particular formulation batch suitable for the purpose. Scanning electron microscopy for surface topography was obtained for drug loaded pellets, coated pellets of the optimized batch before and after dissolution.